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DARAPRIM 25MG TABS - 100 Ct.
DARAPRIM 25MG TABS
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GIVEN IN CONJUNCTION WITH MARQUIS OR SMZ-TRIMETHOPRIM, TO TREAT EPM IN HORSES. The Drug combination of pyrimethamine and sulfadiazine is a commonly prescribed treatment for equine protozoal myeloencephalitis (EPM). Pyrimethamine is an anti-protozoal drug and sulfadiazine is a sulfa antibiotic. These drugs combined have a synergistic effect against Sarcocystis neurona, the protozoa that cause EPM.
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DARAPRIM 25MG TABS - 100 Ct.
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Technical Specs:
Each drug blocks a different step in the metabolism of the protozoa by inhibiting a different enzyme necessary for the synthesis of folic acid. This drug combination does not kill the protozoa; it only inhibits further growth or reproduction. Neither drug alone is considered effective for the treatment of EPM.
The diagnosis and treatment of EPM is a controversial and rapidly evolving field. A great deal of research effort is being focused on this disease, primarily because there is still controversy and disagreement surrounding what constitutes an accurate diagnosis. Treatment for EPM with pyrimethamine/sulfa has been shown to be effective but usually requires long-term medication (12 to 24 weeks). There are conflicting opinions among veterinarians regarding folic acid supplementation for horses on this drug combination. The concern is that long-term use of these drugs might inhibit folic acid metabolism in the horse.
The combination of pyrimethamine, and sulfa may cause anemia, decreased platelets, decreased white blood cell counts, and suppress bone marrow. Pyrimethamine should be used with extreme caution in animals with blood dyscrasias or bone marrow suppression.
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