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DOPRAM-V (doxapram hydrochloride) is a potent respiratory stimulant. It is unique in its ability to stimulate respiration at dosages considerably below those required to evoke cerebral cortical stimulation. 20 ml In nonanesthetized animals the dose required to produce convulsions is some 70 to 75 times the dose required to produce respiratory stimulation. In anesthetized subjects, doxapram also exerts a marked arousal effect. Thus, by promoting the restoration of normal ventilation and producing early arousal following general anesthesia, doxapram minimizes or prevents the undesirable effects of post-anesthetic respiratory depression or hypoventilation and hastens recovery.

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