PRIMOR The treatment of skin and soft-tissue infections (wounds and abscesses) in dogs caused by strains of Staphylococcus aureus and Escherichia coli, and for urinary tract infections caused by Escherichia coli, Staphylococcus spp, and Proteus mirabilis susceptible to SDM-OMP.
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Features:
Plasma protein binding of SDM is very high, providing a blood reservoir of the drug that maintains higher blood levels than most other long-acting sulfonamides.
Single, comparatively low dose gives rapid and sustained therapeutic blood levels.
Potentiation of SDM with OMP provides increased efficacy, broadened spectrum of activity to include some sulfonamide-resistant organisms, and reduction in rate of resistance development.
Suitable for long-term (21-day) treatment
Manufacturer/Label Information:
PRIMOR Dosage and Administration
Administer an initial oral dose of 25 mg/lb (55 mg/kg) of body weight on the first day of treatment. Administer subsequent daily doses at the rate of 12.5 mg/lb (27.5 mg/kg) of body weight. Continue treatment for at least 2 days after remission of clinical signs. Do not extend treatment for more than 21 consecutive days.
For optimal therapeutic effect:
PRIMOR must be given early in the course of disease.
therapeutically effective levels must be maintained throughout the treatment period.
treatment should continue for at least 2 days after remission of clinical signs.
the causative bacterial agents must be sensitive to the drug.
Precautions
Conditions reported following use of sulfonamides or potentiated sulfonamides include polyarthritis, urticaria, facial swelling, fever, haemolytic anemia, polydipsia, polyuria, hepatitis, vomiting, anorexia, diarrhea and neurologic disorders. In rare instances, neurologic signs including behavioral changes, ataxia, seizures, aggression and hyperexcitability have been reported. Keratitis sicca, possibly due to prolonged use of sulfonamides, has been reported.
Individual animal hypersensitivity may result in local or generalized reactions. Anaphylactoid reactions, although rare, may also occur. Antidote for anaphylactoid reactions is epinephrine.
Decreased water consumption and aciduria enhance probability of formation of sulfonamide crystals in urine. As with any sulfonamide therapy, make certain dogs maintain adequate water intake.
If dogs show no improvement in 2 or 3 days, reevaluate the diagnosis.
Safety in breeding dogs has not been established.
PRIMOR is contraindicated in dogs showing marked liver parenchymal damage or blood dyscrasias, or in those with a history of sulfonamide hypersensitivity.
For use in dogs only. Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
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