D-WORM™ 120 LIQUID WORMER

Farnam

pyrantel pamoate

FOR PUPPIES AND DOGS

ANADA #200-248, Approved by FDA

D-Worm™ 120 (pyrantel pamoate suspension 4.54 mg) is a suspension of pyrantel pamoate in a palatable vanilla-flavored vehicle. Each mL contains 4.54 mg of pyrantel base as pyrantel pamoate.

Pyrantel pamoate is a compound belonging to a family classified chemically as tetrahydropyrimidines. It is a yellow, water-insoluble crystalline salt of the tetrahydropyrimidine base and pamoic acid containing 34.7% base activity. The chemical structure and name are given below:

(E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl) vinyl] pyrimidine 4,4' methylenebis [3-hydroxy-2-naphthoate] (1:1)

INDICATIONS FOR USE

D-Worm™ 120 suspension is a highly palatable formulation intended as a single treatment for the removal of large roundworms (Toxocara canis and Toxascaris leonina) and hookworms (Anclyostoma caninum and Uncinaria stenocephala) in dogs and puppies.

D-Worm™ 120 suspension may also be used to prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

DOSAGE AND ADMINISTRATION

Administer one full teaspoon (5 mL) for each 10 lb of body weight (2.27 mg base per lb of body weight). Although most dogs have been observed to find this formulation very palatable and willingly consume it undiluted, it may be necessary to mix a small quantity of formulation in the dog's normal ration to encourage consumption. Fasting prior to or after treatment is not necessary.

For maximum control and prevention of reinfection, it is recommended that puppies be treated at 2, 3, 4, 6, 8 and 10 weeks of age. Lactating bitches should be treated 2-3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals to prevent T. canis reinfection.

CAUTION: THIS PRODUCT IS A SUSPENSION AND AS SUCH WILL SEPARATE. TO ENSURE UNIFORM RESUSPENSION AND TO ACHIEVE PROPER DOSAGE, IT IS EXTREMELY IMPORTANT THAT THE PRODUCT BE SHAKEN THOROUGHLY BEFORE EVERY USE.

RECOMMENDED STORAGE: Store below 86°F (30°C).

EFFICACY

Critical (worm count) studies in dogs demonstrated that D-WORM™ 120 at the recommended dosage is highly efficacious against T. leonina (99%), T. canis (85%), A. caninum (97%), and U. stenocephala (94%).

SAFETY

One of the most outstanding and significant features of D-Worm™ 120 is its wide margin of therapeutic safety in dogs. The acute oral LD₅₀ of pyrantel pamoate administered in gelatin capsules to female and male dogs is greater than 314 mg base per lb of body weight, which indicates a therapeutic index in excess of 138 x the recommended dosage. In subacute and chronic studies, no significant morphological abnormalities could be attributed to D-Worm™ 120 when administered to dogs at daily dose rates of up to 94 mg base per lb of body weight (40 x) for periods of 19, 30, and 90 days. Clinical studies conducted in a wide variety of geographic locations using more than 40 different breeds of dogs showed no drug-induced toxic effects. Included in these studies were nursing pups, weaned pups, adults, pregnant bitches, and males at stud. Additional data have demonstrated the safe use of D-Worm™120 (pyrantel pamoate) in (1) dogs having heartworm infections and/or receiving medication for heartworm, (2) dogs exposed to organophosphate flea collars or flea/tick dip treatments, and (3) dogs undergoing concurrent treatment or medication at the time of worming such as immunization and antibacterial treatment.

FOR ANIMAL USE ONLY

Distributed by:

Farnam Pet Products • A Division of Farnam Companies, Inc.

P.O. Box 34820 • Phoenix, AZ 85067-4820

9CC8

500015

ISS. 8/98

Net Contents: 60 mL (2 fl oz)

Disclaimer: Every effort has been made to ensure the accuracy of the information published. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the product label or package insert. NAC No.: 10000631