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Sentinel  Dog Oral Flea & Tick Control
Sentinel Item# SENT01
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What is Sentinel?
SENTINEL® (milbemycin oxime/lufenuron) Flavor Tabs® control flea populations and adult hookworms, and remove and control adult roundworm and whipworm infections in dogs and puppies.

Who is Sentinel for?
Dogs and puppies four weeks of age or older.

Why use Sentinel?
- Control Flea Infestations
- Prevent heartworm Disease
- Treat and control round worms
- Treat and control whipworms
- Treat heartworm and protect against infestations.
- Beef flavor for dogs

How Sentinel work?
Milbemycin oxime, one active ingredient in SENTINEL Flavor Tabs, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxocara canis and Toxascaris leonina) and whipworm (Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule.

Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. Concurrent use of an adulticide product may be necessary for adequate control of adult fleas.


Active ingredient(s):
milbemycin oxime - lufenuron

How is Sentinel sold?
SENTINEL Flavor Tabs are available in four tablet sizes in color-coded packages for oral administration to dogs and puppies according to their weight. (See Dosage Section). Each tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 4.55 mg/pound (10 mg/kg) body weight of lufenuron.

What special precautions are there?
Do not use in puppies less than four weeks of age and less than two pounds of body weight. Prior to administration of SENTINEL Flavor Tabs, dogs should be tested for existing heartworm infections.

What to do if overdose?
Contact your nearest emergency animal hospital

How can I store Sentinel?
Store at room temperature. Keep this and all drugs out of the reach of children.

Helpful Tips:
SENTINEL Flavor Tabs may be used concurrently with CAPSTAR®
,(nitenpyram) Tablets to provide a Flea Management System that kills adult fleas and prevents flea eggs from hatching. Please see the Supplemental Package Insert provided with this product for information about concurrent use of the two products.

SENTINEL Flavor Tabs are given orally, once a month, at the recommended minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime and 4.55 mg/lb (10 mg/kg) lufenuron.

* Please see separate insert in this package for concurrent dosing of SENTINEL Flavor Tabs and CAPSTAR Tablets. 



SENTINEL Flavor Tabs are palatable and most dogs will consume the tablet when offered by the owner. As an alternative to direct dosing, the tablets can be hidden in food. Be certain the dog consumes the entire tablet or tablets. Administer SENTINEL Flavor Tabs to dogs, immediately after or in conjunction with a normal meal. Food is essential for adequate absorption of lufenuron. Watch the dog closely following administration to be sure the entire dose has been consumed. If it is not entirely consumed, redose with the full recommended dose as soon as possible.

SENTINEL Flavor Tabs must be administered monthly, preferably on the same date each month. Treatment with SENTINEL Flavor Tabs may begin at any time of year. In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until the end of “mosquito and flea season.” In areas with year-round infestations, treatment should continue through the entire year without interruption. 


Step 1: Control

Give SENTINEL Flavor Tabs once per month to prevent and control flea populations. SENTINEL Flavor Tabs contain lufenuron. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. If a dog currently has a flea infestation, more rapid relief can be accomplished by adding CAPSTAR to the treatment as follows.


Step 2: Kill Adult Fleas

If your pet currently has a flea infestation, add CAPSTAR Tablets to kill adult fleas. CAPSTAR Tablets contain nitenpyram and are effective for the treatment of flea infestations. Nitenpyram starts killing adult fleas within 30 minutes of administration.

- Administer CAPSTAR Tablets once per week until adult fleas are no longer observed.

- For a severe flea infestation, administer CAPSTAR Tablets twice per week until adult fleas are no longer observed.

- Additional CAPSTAR Tablets may be administered as needed to kill the occasional adult flea picked up from infested environments.

- It is important to treat all cats and dogs in the household. All cats should be treated with approved products like lufenuron in combination with nitenpyram as needed. Fleas can reproduce on untreated pets and allow infestations to persist.



The combination of SENTINEL Flavor Tabs and CAPSTAR Tablets should be administered according to the following schedule. Weigh your dog prior to administration to ensure proper dosage. Do not administer to dogs under 2 pounds or less than 4 weeks of age.

Administer with a normal meal.


Sentinel Recommended Dosage

Body Weight



300 - 749 lb


46 mg

750 – 1,249 lb


115 mg

1,250 – 1,749 lb


230 mg

1,750 – 2,249 lb


460 mg

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