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 Dog Antibiotics
Simplicef Tablet Item# 25905
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Simplicef Tablet

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What is Simplicef Tablet?
SIMPLICEF tablets are often prescribed for the treatment of skin infections (wounds and abscesses) in dogs caused by susceptible strains of Staphylococcus intermedius, Staphylococcus aureus, Streptococcus canis (group G, ß hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.

Who is Simplicef Tablet for?

Why use Simplicef Tablet?
- Convenient, once-a-day dosing
- Treats many different types or infections such as respiratory tract, as well as ear, skin, and urinary tract infections.
- SIMPLICEF (cefpodoxime proxetil) is the first oral once-daily cephalosporin that's FDA approved for veterinary use in the treatment of canine skin infections. It's designed to be convenient and a good value for your large dog clients.

How Simplicef Tablet work?
Simplicef is effective against most gram-positive and gram-negative bacteria. Cephalosporin antibiotics suppress the growth of micro-organisms such as bacteria, fungi, or protozoa. Simplicef is well absorbed from the intestinal tract and is carried by the blood stream to many tissues of the body. To be effective, Simplicef must be given for multiple days in a row. If doses are missed or the entire treatment regimen is not completed, the infection could recur or worsen. Consult your veterinarian if the animal's condition does not improve or worsens after beginning treatment with Simplicef.

Generic Brands:
Cefpodoxime proxetil


Active ingredient(s):
Cefpodoxime Proxetil

How is Simplicef Tablet sold?
100 mg
200 mg

What are the side effects of Simplicef Tablet?
Side effects are rare. You may see lack of appetite, vomiting, or diarrhea. If you observe any of the above signs in your pet, contact your veterinarian

What special precautions are there?
The safety of cefpodoxime proxetil in dogs used for breeding, pregnant dogs, or lactating bitches has not been demonstrated. As with other cephalosporins, cefpodoxime proxetil may occasionally induce a positive direct Coombs’ test.

What to do if overdose?
Contact your veterinarian or veterinary emergency room. Symptoms of overdose (thyrotoxicosis) may include increased thirst, urination and hunger, hyperactivity, personality change, and reduced heat tolerance.

How can I store Simplicef Tablet?
Store at room temperature (15-30°C).

Give this medication exactly as directed by your veterinarian. 
Simplicef should be given with food to increase absorption in the body. Keep plenty of water available for your pet to drink. Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet as this may decrease the absorption of Simplicef. Give all of the Simplicef even if your pet appears to be better. Symptoms may improve before the infection is completely treated.
The usual dose of Simplicef in dogs is 2.3-4.5mg/pound, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days.
Cefpodoxime proxetil
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