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Prascend Tablets Horse Cushing''s Disease
Prascend Tablets 1 mg Item# 32483
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Prascend Tablets 1 mg

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What is Prascend Tablets 1 mg?
Prascend Tablets effectively reduce the signs and symptoms of cushings disease in horses (Pituitary Pars Intermedia Dysfunction).

Who is Prascend Tablets 1 mg for?

Why use Prascend Tablets 1 mg?
Reduces signs like fat in unusual places or an abnormal hair coat.
The first and only medicine available in the US to treat PPID (equine Cushing's disease)
Fully approved by the FDA

How Prascend Tablets 1 mg work?
Prascend tablets work as a dopamine receptor agonist used orally in horses.

Boehringer Ingelheim

Active ingredient(s):
pergolide mesylate

How is Prascend Tablets 1 mg sold?
60 Tablets
120 Tablets

What are the side effects of Prascend Tablets 1 mg?
In some cases decreased appetite, lameness, diarrhea/loose stool, colic, lethargy, abnormal weight loss, laminitis, heart murmur, tooth disorder, skin abscess, musculoskeletal pain & behavior change.

What special precautions are there?
Prascend tablets should not be crushed due to the risk of human exposure. Instead, dissolve Prascend tablets in water and syringed into the horse's mouth or top dressed on his feed, or the undissolved tablet may be placed into an apple or other treat and given to the horse.

What to do if overdose?
Contact your nearest emergency animal hospital.

How can I store Prascend Tablets 1 mg?
Store at or below 25°C (77°F)

Helpful Tips:
Talk to your veterinarian to see if PRASCEND is right for your horse.

Administer orally at a starting dose of 2.0 µg/kg once daily. Dosage may be adjusted to effect, not to exceed 4.0 µg/kg daily. Prascend Tablets should not be crushed due to the potential for increased human exposure.

The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment.

Recommended Dosage Schedule for Horses

Body Weight

Dosage 2 mcg/kg

Dosage 4 mcg/kg

300 - 749 lb

0.5 tablet

1 tablet

750 – 1,249 lb

1 tablet

2 tablets

1,250 – 1,749 lb

1.5 tablets

3 tablets

1,750 – 2,249 lb

2 tablets

4 tablets


Dosing should be titrated according to individual response to therapy to achieve the lowest effective dose. Dose titration is based on improvement in clinical signs associated with Pituitary Pars Intermedia Dysfunction (PPID) and/or improvement or normalization of endocrine tests (for example, dexamethasone suppression test or endogenous ACTH test). If signs of dose intolerance develop, the dose should be decreased by half for 3 to 5 days and then titrated back up in 2 mcg/kg increments every 2 weeks until the desired effect is achieved.

Prascend Tablets are rectangular light red colored, half-scored tablets containing 1 mg pergolide, as pergolide mesylate.

Pergolide mesylate is a synthetic ergot derivative and is a potent dopamine receptor agonist. The chemical name of pergolide mesylate is 8β-[(Methylthio) methyl]-6-propylergoline monomethanesulfonate.

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