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Kinavet CA1- 30 Coated Tablets Rx

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Kinavet- Ca1 is the first approvaed anticancer drug in veterinary medicine. It's cutting edge technology works directly at the origin of the tumor and is indicated for the treatment of recurrent (post-surgery)or nonresectable Grade II or III cutaneous mast cell tumors in dogs that have not previously received radiotherapy and/or chemotherapy except corticosteroids.

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What is Kinavet CA1- 30 Coated Tablets?

Kinavet- Ca1 is the first approvaed anticancer drug in veterinary medicine. It's cutting edge technology works directly at the origin of the tumor and is indicated for the treatment of recurrent (post-surgery)or nonresectable Grade II or III cutaneous mast cell tumors in dogs that have not previously received radiotherapy and/or chemotherapy except corticosteroids.

Who is Kinavet CA1- 30 Coated Tablets for?

Dogs & Cats

Why use Kinavet CA1- 30 Coated Tablets?

- 85% response rate to Kinavet.
- Off-label use for feline asthma
- Kinavet-CA1 is used to treat Canine Atopic Dermatitis
- Kinavet-CA1 is delivered orally in tablet form and can be administered
- Kinavet-CA1 is used to treat Melanoma in dogs and thyroid Carcinoma.
- Kinavet-CA1 is used to treat Osteosarcoma & other soft tissue sarcoma in dogs.
- Targets mast cells and is approved for the treatment of non-resectable canine mast cell tumors*.

How Kinavet CA1- 30 Coated Tablets work?

Kinavet-CA1®, a tyrosine kinase inhibitor, is a drug used to treat mast cell tumors, a common form of cancer that affects dogs. Kinavet-CA1® works in three ways:
- Kinavet-CA1 works by blocking the survival signal of the tumor cells, which may induce disappearance of the tumor
- Kinavet-CA1 works by preventing tumor growth.
- Kinavet-CA1 works by preventing the spread of tumor cells (metastasis).

Manufacturer:

AB Science

Active ingredient(s):

Masitinib Mesylate

How is Kinavet CA1- 30 Coated Tablets sold?

50 mg Tablets
150 mg Tablets

What are the side effects of Kinavet CA1- 30 Coated Tablets?

The most common side effects that may occur with Kinavet-CA1® include diarrhea and vomiting. Kinavet-CA1® also showed a risk of reversible protein loss syndrome, which is not dangerous for your animal if regular surveillance of blood albumin level is performed by your veterinarian to ensure that treatment is interrupted before any symptoms occur. To see the potential side-effects of of Kinavet-CA1® in canines, please refer to the package insert.

What special precautions are there?

Do not use Kinavet CA1® in dogs suffering from liver or renal function impairment and in dogs with anemia or with neutropenia.
CBC/Chem profile / Urine Analysis should be monitored every few weeks to start than as needed thereafter (the reason being is because 95% of the dogs and inhibits the proliferation of mast cell tumors.

What to do if overdose?

Contact your nearest emergency animal clinic.

How can I store Kinavet CA1- 30 Coated Tablets?

Keep at controlled room temperature (15-25°C; 59-77°F), in the original packaging, away from a source of heat or humidity.

Helpful Tips:

Regular checkups by your veterinarian are necessary to determine if your dog is responding as expected, or to decide whether your dog should receive a different daily dose of Kinavet-CA1®. Kinavet is NOT a chemotherapeutic agent or is not assiciated with any chemo treatment, Kinavet is a tyrosine kinase inhibitor. Conjuctive therapy is acceptable (i.e. Prednisone).
Dosage and Administration: Follow directions Given by your veterinarian. 

Your veterinarian will decide the length of treatment with Kinavet-CA1®. Regular checkups with your veterinarian are required. 

Always READ Client Information Sheet with prescription.

Administer KINAVET-CA1 at an initial dose of 12.5 mg/kg/day (5.7 mg/lb/day) orally, once daily with food . Dose reductions to 9 mg/kg/day (4.1 mg/lb/day) and dose interruptions may be utilized, if needed, to manage adverse reactions (see WARNINGS and PRECAUTIONS). Do not split or crush tablets

masitinib mesylate

Has your pet has been diagnosed with a mast cell tumor, by a qualified veterinarian.  The cancer type is also called MCT or mastocytoma. Mastocytoma (MCT) is among the most common forms of cancer in dogs. 


Mast cells are cells that are found in the connective tissues, especially those vessels and nerves that are closest to the external surfaces (e.g., skin, lungs, nose, mouth). Their primary function of the cells include defense against parasitic infestations, tissue repair, and the formation of new blood vessels (angiogenesis). They are also associated with allergic reactions, since they contain several types of dark granules made up of various chemicals, including histamine and heparin, serving biologically to modify immune reactions and inflammation. Mast cells are derived from the bone marrow, and can be found in various tissues throughout the body.


The origin of Mastocytoma is a deregulated proliferation of normal cells in the skin (mast cells) that leads to a dangerously abnormal growth of these cells and formation of a tumor.

 It is not contagious to humans or other animals.


Mast cell tumors (or mastocytomas) are graded according to their location in the skin, presence of inflammation, and how well they are differentiated.  MCT has various forms and varies widely in size, shape, appearance, texture, and location. These tumors often behave in an aggressive manner, spreading to secondary body locations (metastasizing) and releasing chemicals that cause systemic problems such as loss of appetite, vomiting, diarrhea, abdominal pain, itchiness, lethargy, and anemia. If left untreated, MCT can be lethal and will very probably have a negative effect on your dog’s lifespan and quality of life.


Boxers, bulldogs, pugs, and Boston terriers appear to be more susceptible to mast cell tumors than other breeds. The mean age for the development of this condition is eight years in dogs, though it has been reported in animals less than one year of age.


Up to 25 percent of skin tumors in dogs and cats are mast cell tumors. These tumors often behave in an aggressive manner, metastasizing to local lymph nodes, the liver, spleen, and bone marrow.


Kinavet-CA1® is a cutting-edge technology working directly at the origin of the tumor.

Kinavet-CA1® belongs to the family of drugs called tyrosine  kinase receptor inhibitors, which over the last decade have helped to revolutionize the management of certain human  cancers and have now been successfully developed for veterinary medicine.


This targeted therapy inhibits cellular signaling pathways that regulate key cell functions and survival. Responses vary from complete disappearance of the tumor to no impact at all. However, clinical studies demonstrated that 62% of dogs treated by Kinavet-CA1® were still alive after 12 months of therapy.


Treatment With Kinavet- CA1 

  • - Leads to long term tumor control.
  • - Kinavet-CA1®is not a chemotherapy drug.
  • - Responses vary from complete disappearance  of the tumor to no impact at all. However, clinical studies demonstrated that 62% of dogs treated by Kinavet-CA1® were still alive after 12 months of therapy.
  • - Kinavet-CA1® is easy to use and can be administered by the owner at their home. The tablets are given by mouth once a day.


Allivet carries Kinavet-CA1 at the best prices. Speak with your Veterinarian about Kinavet-CA1. Also be sure to let your veterinarian know which other pet medication your pets are taking. 

 

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