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Item No.
10049
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Legend 10mg/ml 4ml Vial Description
LEGEND® (hyaluronate sodium) Injectable Solution and LEGEND® Multi Dose (hyaluronate sodium) Injectable Solution is a clear, colorless solution of low viscosity.
- LEGEND Injectable Solution 4 mL are pyrogen free, sterile and do not contain a preservative.
- LEGEND 4 mL is for intravenous use only.
- LEGEND Multi Dose Injectable Solution is pyrogen free and sterile and contains benzyl alcohol as a preservative. It is administered by intravenous injection only.
Hyaluronic acid, the conjugate acid of hyaluronate sodium, is extracted from the capsule of
Streptococcus spp. and purified, resulting in a form which is essentially free of protein and nucleic acids.
LEGEND Injectable Solution is supplied in 4 mL (40mg) vials. Each mL contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic, and 0.04 mg sodium phosphate monobasic. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid.
What is Legend 10mg/ml 4ml Vial?
LEGEND Injectable Solution is for the treatment of horses suffering from joint dysfunction of the carpus or fetlock due to non-infectious synovitis associated with equine osteoarthritis.
Which animals/pets is Legend 10mg/ml 4ml Vial for?
For use in horses.
Legend 10mg/ml 4ml Vial uses
LEGEND may be administered intravenously or by intra-articular injection into the carpus or fetlock allowing flexibility for individual situations.
LEGEND is disease and symptom modifying.
The drug has FDA approval and is proven safe and effective, and it’s been used successfully for more than 25 years.
What does Legend 10mg/ml 4ml Vial do?
LEGEND® (hyaluronate sodium) Injectable Solution contains the conjugate acid hyaluronic acid which is a naturally occurring substance found in high concentrates in the synovial fluid. Hyaluronic acid regulates normal cellular constituents, exerting anti-inflammatory action and when directly injected into the joint helps restore lubrication of the joint fluid.
Legend 10mg/ml 4ml Vial side effects
No local or systemic side effects were observed in the field studies using LEGEND intravenously. The following adverse reactions were reported in voluntary post-approval reporting: occasional depression, lethargy, and fever.
The following adverse reactions have been reported following use of intra-articular LEGEND Injectable Solution (2 mL only) use: lameness, joint effusion, joint or injection site swelling, and joint pain.
Legend 10mg/ml 4ml Vial ingredients
hyaluronate sodium
Legend 10mg/ml 4ml Vial overdose: What to do?
Contact your closest emergency pet hospital.
What to know before using Legend 10mg/ml 4ml Vial
Radiographic evaluation should be carried out in cases of acute lameness to ensure that the joint is free from serious fractures. As with any intra-articular (LEGEND Injectable Solution – 2 mL only) treatment, special precautions must be followed as to injection technique and sterility for prevention of possible swelling or infection. Intra-articular injections should not be made through skin that has been recently fired or blistered, or that has excessive scurf and counterirritant on it.
The safety of LEGEND Injectable Solution and LEGEND Multi Dose Injectable Solution has not been evaluated in breeding stallions or in breeding, pregnant or lactating mares.
How is Legend 10mg/ml 4ml Vial sold?
Sold as individual 4 ml vial
Manufacturer
Boehringer Ingelheim
Tips for using Legend 10mg/ml 4ml Vial
The joint fluid contains high concentrations of hyaluronate, and it also occurs naturally within the body. The hyaluronate in this medication is believed to help regulate joint cells that can increase inflammation. After injection into the joint, hyaluronate works to help the joint lining heal and increases the joint fluid thickness. This fluid works to cushion and lubricate the joints, protecting the lining.
Overview
LEGEND Injectable Solution 2 mL: Intra-articular-2 mL in the carpus or fetlock. Strict aseptic technique should be observed when administering by intra-articular injection. As with any intra-articular procedure, proper injection site disinfection and animal restraint are important.
Excess joint fluid should be aseptically removed prior to injection. Care should be taken to avoid scratching the cartilage surface with the tip of the injection needle. Diffuse swelling lasting 24 to 48 hours may result from movement of the needle while in the joint space. Horses should be given stall rest after treatment before gradually resuming normal activity. Discard any unused portion of the drug and empty vial after opening.
LEGEND Injectable Solution 4mL and LEGEND Multi Dose Injectable Solution: 4 mL injected intravenously. Treatment may be repeated at weekly intervals for a total of three treatments. Use aseptic technique and inject slowly into the jugular vein. Horses should be given stall rest after treatment before gradually resuming normal activity. Discard any unused portion of the drug and empty vial after opening. For LEGEND Multi Dose Injectable Solution only, discard 6 months after first use.
Main Ingredients
Hyaluronic acid, the conjugate acid of hyaluronate sodium, is extracted from the capsule of Streptococcus spp. and purified, resulting in a form which is essentially free of protein and nucleic acids.
Legend Injectable Solution is supplied in 2 mL (20 mg) vials. Each mL contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic and 0.04 mg sodium phosphate monobasic. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid.
