What is Legend 10mg/ml 4ml Vial?
Legend is an injectable medication used to treat inflammation of the lining of the joint and for the treatment of joint dysfunction of the carpus or fetlock in horses. The hyaluronate in Legend is thought to help regulate cells in the joint that would increase inflammation.
Who is it for?
In Horses Only
Why use it?
- Aids in restoring joint fluid
- Reduces inflammation of the joints in horses
- Aids in reducing symptoms of joint disease
How it works?
Hyaluronate molecules are long chains which form a filter network interspersed with normal cellular fluids. It is widely accepted that injection directly into the joint pouch enhances the healing of inflamed synovium by restoring lubrication of the joint fluid. This further supplements the visco-elastic properties of normal joint fluid.
Bayer Animal Health
How is it sold?
Legend 10mg/ml 4ml Vial
Legend 10mg/ml 4ml Box of 6 Vials
What are the side effects?
No local or systemic side effects were observed in the clinical field trials with either intravenous or intra-articular injections.
What special precautions are there?
Safety in breeding animals has not been determined with Legend Injectable Solution.
Radiographic evaluation should be carried out in cases of acute lameness to ensure that the joint is free from serious fractures. As with any intra-articular treatment, special precautions must be followed as to injection technique and sterility for prevention of possible swelling or infection. Intra-articular injections should not be made through skin that has been recently fired or blistered, or that has excessive scurf and counterirritant on it.
What to do if overdose?
Contact your nearest emergency animal hospital
How Can I store it?
Do not store above 40° C (104° F)
Hyaluronate is found in high concentrations in joint fluid and occurs normally in the body. The hyaluronate in Legend is thought to help regulate cells in the joint that would increase inflammation. When injected into the joint, hyaluronate helps the lining of the joint to heal and helps to increase the thickness of the joint fluid. This joint fluid lubricates and cushions the joint and helps protect the joint lining.
Legend® (hyaluronate sodium) Injectable Solution is indicated in the treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis.
Legend Hyaluronate Sodium is FDA approved for use in veterinary medicine. The usual dose in horses is 4 ml (40 mg) I.V or 2ml (20 mg) intra-articular in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments.
Legend (hyaluronate sodium) Injectable Solution is a clear, colorless solution of low viscosity. Legend Injectable Solution is pyrogen free, sterile and does not contain a preservative. It is administered by intravenous or intra-articular injection.
Legend Dosage and Administration:
Intravenous-4 mL (40 mg). Intra-articular-2 mL (20 mg) in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments.
Strict aseptic technique should be observed when administering by intra-articular injection. As with any intra-articular procedure, proper injection site disinfection and animal restraint are important. Excess joint fluid should be aseptically removed prior to injection. Care should be taken to avoid scratching the cartilage surface with the tip of the injection needle. Diffuse swelling lasting 24 to 48 hours may result from movement of the needle while in the joint space.
For intravenous administration, use aseptic technique and inject slowly into the jugular vein.
Horses should be given stall rest after treatment before gradually resuming normal activity.
Discard any unused portion of the drug and the empty vial after opening.
Hyaluronic acid, the conjugate acid of hyaluronate sodium, is extracted from the capsule of Streptococcus spp. and purified, resulting in a form which is essentially free of protein and nucleic acids.
Legend Injectable Solution is supplied in 2 mL (20 mg) vials. Each mL contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic and 0.04 mg sodium phosphate monobasic. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid.