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Lutalyse
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Lutalyse Rx

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Lutalyse Description
Lutalyse is an effective luteolytic agent for mares and cattle and is used to induce parturition in swine.
What is Lutalyse?
Lutalyse used as a luteolytic agent in cattle, parturition induction in swine, and luteolytic effect in mares. This product contains the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt.
Which animals/pets is Lutalyse for?
For use in cattle, swine, and mares.
Lutalyse uses
Lutalyse has a luteolytic effect on cattle and mares and works to induce parturition in swine.
What does Lutalyse do?
This product uses dinoprost tromethamine to:
  • Control estrous timing in estrous cycling mares or in clinically anestrous mares with a corpeus luteum
  • Induce parturition in swine
  • Induce abortion in non-lactating or feedlot cattle
  • Treat chronic endometriosis (pyometra) and silent (unobserved) estrus in cattle
  • Synchronize estrus in cattle
Lutalyse side effects
Potential side effects include:

In mares:
  • Decrease in rectal temperature
  • Sweating
These effects are transient and are not detrimental.
  • Other potential reactions include:
    • Lying down
    • Locomotor incoordination
    • Abdominal discomfort
    • Increased respiration rate
    • Increased heart rate
    These reactions typically occur within 15 minutes of injection and resolve within an hour. Even while experiencing a reaction, mares typically continue eating. In a study of several hundred mares on Lutalyse, a single anaphylactic reaction was reported, but was not substantiated.

    In swine:
    • Vomiting (at a dose of 100mg)
    • Salivation
    • Increased vocalization
    • Dyspnea
    • Hyperpnea
    • Tail movements
    • Abdominal muscle spasms
    • Defecation
    • Urination
    • Itching
    • Nesting behaviors
    • Slight incoordination
    • Pruritus
    • Erythema
    These reactions are typically short-term (10 minutes to 3 hours) and non-detrimental.

    In cattle:
    • Limited salivation
    • Lutalyse ingredients
    Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 9.45 mg added as preservative.
    Lutalyse overdose: What to do?
    Immediately contact your closest emergency animal hospital.
    What to know before using Lutalyse
    • Pregnancy status should be determined in mares prior to injection. This medication can induce parturition and abortion.
    • Mares with subacute or acute disorders of the reproductive tract, respiratory system, gastrointestinal tract, or vascular system should not take this medication.
    • Employ aggressive antibiotic treatment at the first sign of injection site infection, whether diffuse or localized.
    • Never administer intravenously.
    • Prostaglandin synthesis can be inhibited with concurrent NSAID use. Do not administer with any other NSAID.
    • Never administer to pregnant cattle, except in cases where abortion is desired.
    • Cattle on progestin will have reduced response to this injection.
    • Never administer to gilts or sows before 3 days of predicted normal farrowing. An increased rate of postnatal mortality and stillbirths can occur.
    • This injection is not effective if it is administered before day 5 following ovulation in mares.
    • A severe localized clostridial infection can occur and, rarely, result in death.
    • Not for use in animals intended for food slaughter.
    • Drug residues can result when administered in any dose greater than approved.
    • No withdrawal period is required before slaughter of swine.
    • No pre-slaughter or milk discard is required for cattle.
    • Do not administer to humans.
    • Keep away from children.
    • Humans with respiratory or bronchial issues, asthmatics, and women of childbearing age must use extreme caution in the handling of this product. In early stages, a woman can be unaware of pregnancy. This medication is easily and readily absorbed into the skin, which can cause bronchospasm and/or abortion.
    • Accidental skin spillage must be immediately washed off using soap and water.

      • For a copy of the SDS (Safety Data Sheet), technical support, or to report a suspected adverse reaction, Zoetis, Inc. may be contacted at 1-888-963-8471.
      For more information about side effect reporting of animal drugs, contact the FDA by calling 1-888-FDA-VETS, or go to http://www.fda.gov/AnimalVeterinary/SafetyHealth.
    How is Lutalyse sold?
    -30 ml -100 ml
    Manufacturer
    Zoetis
    Overview
    Use as directed by your veterinarian.
    Main Ingredients
    Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 9.45 mg added as preservative.