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K9 Advantix II for Dogs

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Product Overview

How To Use

What’s in it?



Questions & Answers

Product Description

K9 Advantix II is a topical medication used to treat and prevent mosquitoes, fleas, eggs, and ticks when used monthly. See Allivet's Flea and Tick Chart to find which flea and tick product is best for your pet.

What is K9 Advantix II for Dogs?

K9 Advantix II is a topical prevention of external parasites on dogs. Controls fleas and ticks, flea eggs and mosquitoes. Repels and kills ticks including Deer ticks (vector of Lyme disease), American dog ticks (vector of Rocky Mountain spotted fever), Brown dog ticks (vector of ehrlichiosis), and Lone Star ticks for up to four weeks Kills 98-100% of the fleas on dogs within 12 hours and continues to prevent infestations for at least four weeks . K9 Advantix II kills fleas before they lay eggs. Following contact with a K9 Advantix II, Larval flea stages in the dog's surroundings are killed in the treated dog . It also repels and kills mosquitoes for up to four weeks •

Who is K9 Advantix II for Dogs for?

For use in puppies (ages 7 weeks and up) and dogs.

Why use K9 Advantix II for Dogs?

Features of K9 Advantix II:
  • Available over the counter
  • Kills mosquitoes, lice, ticks, and fleas
  • Kills chewing lice and repels biting flies
  • Provides a full month of protection
  • Ends the life cycle of fleas by preventing the offspring of fleas (larvae, pupae, and eggs) from maturing into adults
  • Reduces risk of stress and parasite-transmitted illnesses
  • Remains effective even after swimming or bathing
  • Easy, convenient application

How does K9 Advantix II for Dogs work?

When you apply K9 Advantage to your pet, it spreads at the hair root level over the skin's surface, assisted by the movement of the body, which provides all-over coverage. This revolutionary chemistry impairs the flea's nervous system, which kills the flea. Since reinfestation is likely to come from outdoors or the pet's environment, those new fleas will also be killed within 2 hours. K9 Advantage protects your pet from further infestation of fleas for up to one month.


Bayer Animal Health

Active ingredient(s):

  • Permethrin* - 44.00%
  • Imidacloprid- 8.80%
  • Pyriproxyfen - 0.44%
  • Other Ingredients - 46.76%

How is K9 Advantix II for Dogs sold?

Sold in 2, 4, 6, and 12 month supplies based on your dog's weight. Boxes are color coded to your dog's weight.
  • Green: Up to 10 pounds
  • Teal: 11 - 20 pounds
  • Red: 21 - 55 pounds
  • Blue: Over 55 pounds

What are the side effects of K9 Advantix II for Dogs?

Rarely, the following side effects have been noted in dogs between six and nine days following application:
  • Unsteadiness
  • Depression
  • Weakness
These symptoms resolved by day ten post-application with no intervention.

The following side effects also occurred during laboratory effectiveness studies after application, and could be attributed directly to this medication. They may also be secondary to the burden of intestinal parasites or other pre-existing conditions.
  • Nasal discharge
  • Ocular discharge
  • Coughing
  • Lethargy
  • Anorexia
  • Vomiting
  • Bloody stools
  • Diarrhea
Reactions at the application site could include:
  • Mild erythema (skin redness)
  • Appearance of white deposits on hair
  • Greasy or stiff hair
These reactions typically resolved without intervention within 2 and 48 hours.

What special precautions are there?

  • Refer to K9 Advantix II Adverse Reactions if your pet experiences any side effects to this medication.
  • Separate dogs for 12 hours following product application, ensuring that the product is completely dry, if your household also includes cats.

What to do if overdose?

Contact your closest emergency animal hospital.

How can I store K9 Advantix II for Dogs?

Don't refrigerate. Store in a dry and cool place.

Helpful Tips:

Do not handle treated dogs, or allow children to do so, until the site of application dries. You can help ensure this by treating your dog in the evening and not allowing them to sleep with children or other human family members.


Advantix® is easy to apply – one dose, once or twice a month, simply applied onto the skin of the animals and available in four different pipette sizes. A small dog below 4 kg weight requires no more than a single spot on its neck with the advantix® 0.4 ml pipette. For a big dog of more than 25 kg weight the advantix® 4.0 ml pipette should be applied on four spots along its back.
With monthly treatment the pet gains year-round protection against nasty parasites. For dermal use only.
The dog should be standing for easy application. The entire contents of the advantix® pipette should be applied evenly to four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the pipette on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
Indications for use
Advantix® Spot on is designed for dermal application. Dogs with body weights under 10 kg should be treated at a single spot. The recommended minimum dose is: 10 mg/kg body weight (bw) Imidacloprid and 50 mg/kg body weight (bw) Permethrin.

Dogs (kg bw)

Trade name

Volume (ml)

Imidacloprid (mg/kg bw)

Permethrin (mg/kg bw)

<= 4 kg

advantix® Spot-on for dogs up to 4 kg

0.4 ml

minimum of 10

minimum of 50

>4 up to 10 kg

advantix®  Spot-on for dogs over 4 up to 10 kg

1.0 ml

10 - 25

50 - 125

>10 up to 25 kg

advantix®  Spot-on for dogs over 10 up to 25 kg

2.5 ml

10 - 25

50 - 125

>25 up to 40 kg

advantix® Spot-on for dogs over 25 kg

4.0 ml

10 - 16

50 - 80

Treatment Recommendations
To reduce re-infestation from emergence of new fleas, it is recommended to treat all dogs in a household. Other per animals living in the same household should also be treated with a suitable product. To aid further in reducing environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developmental stages is recommended. 

Main Ingredients

Active Ingredients  /   % By Weight
Imidacloprid                      8.80%
Permethrin*                      44.00%
Pyriproxyfen                      0.44%
Other Ingredients              46.76%
Total                                 100.0%
*cis/trans ratio: max 55% (±) cis and min 45% (±) tr

How to Combat Flea and Tick Attacks in Winter. Read the article here.

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K9 Advantix II for Dogs

Customer Submitted Questions

My dog weighs 166 lbs. Will the Blue pack (over 55 lbs) be enough or do I need to buy a combination of packages to match his weight?

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