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NAXCEL Rx

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Product Overview

How To Use

What’s in it?

Reviews

Questions & Answers

Product Description

NAXCEL® Sterile Powder is made with ceftiofur sodium salt, a comprehensive cephalosporin antibiotic that works against gram-negative and gram-positive bacteria, including strains that produce b-lactamase. As with other cephalosporin drugs, ceftiofur is bactericidal in vitro, which inhibits synthesis of the cell wall. It does not contain sterile water.

What is NAXCEL?

NAXCEL is a broad spectrum antibiotic used for treatment of bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida and Haemophilus somnus. NAXCEL also is indicated for treatment of acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.

Who is NAXCEL for?

For use in day-old chicks, dogs, horses, goats, sheep, swine, and cattle.

Why use NAXCEL?

Features of NAXCEL®:
  • Effective in treating canine urinary tract infections associated with Proteus mirabilis and Escherichia coli (E. coli)
  • Works to control early mortality commonly associated with Escherichia coli organisms
  • Known to treat respiratory infections in horses caused by Streptococcus zooepidemicus
  • Can be used to treat caprine respiratory disease (goat pneumonia), bovine respiratory disease (BRD), swine bacterial respiratory disease (swine bacterial pneumonia), and sheep respiratory disease (sheep pneumonia)
  • Effective in treating pneumonia and foot rot with impressive results
  • First antibiotic that does not require milk discard

How does NAXCEL work?

NAXCEL® Sterile Powder includes ceftiofur sodium salt, which is a comprehensive cephalosporin antibiotic that works against gram-negative and gram-positive bacteria, including ß-lactamase-producing strains.

Manufacturer:

Zoetis

Active ingredient(s):

Each mL of the reconstituted drug contains ceftiofur sodium equivalent to 50 mg ceftiofur. The pH was adjusted with sodium hydroxide and monobasic potassium phosphate.

How is NAXCEL sold?

Sold in 1 gram or 4 gram bottles.

What are the side effects of NAXCEL?

Transient and immediate local pain may be experienced with ceftiofur use.

What special precautions are there?

Safety has not been proven for use in breeding or pregnant dogs.

What to do if overdose?

Contact your closest emergency pet hospital.

How can I store NAXCEL?

Protect from light. Color of the cake may vary from off-white to a tan color. Color does not affect potency. Store unreconstituted product at controlled room temperature 20° to 25° C (68° to 77° F). Store reconstituted product either in a refrigerator 2° to 8° C (36° to 46° F) for up to 7 days or at controlled room temperature 20° to 25° C (68° to 77° F) [see USP] for up to 12 hours.

Helpful Tips:

NAXCEL® provides the assurance of zero milk discard, unlike many other antibiotic options, which can cause adverse milk residues and waste milk.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.

Overview

Indications:
 
Cattle
NAXCEL Sterile Powder is indicated for treatment of bovine respiratory disease (shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. NAXCEL Sterile Powder is also indicated for treatment of acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.
 
Swine
NAXCEL Sterile Powder is indicated for treatment/control of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis.
 
Sheep
NAXCEL Sterile Powder is indicated for treatment of sheep respiratory disease (sheep pneumonia) associated with Mannheimia haemolytica and Pasteurella multocida.
 
Goats
NAXCEL Sterile Powder is indicated for treatment of caprine respiratory disease (goat pneumonia) associated with Mannheimia haemolytica and Pasteurella multocida.
 
Horses
NAXCEL Sterile Powder is indicated for treatment of respiratory infections in horses associated with Streptococcus zooepidemicus.
 
Dogs
NAXCEL Sterile Powder is indicated for the treatment of canine urinary tract infections associated with Escherichia coli and Proteus mirabilis.
 
Day-old Chicks
NAXCEL Sterile Powder is indicated for the control of early mortality, associated with E. coli organisms susceptible to ceftiofur, in day-old chicks.
 
Day-old Turkey Poults
NAXCEL Sterile Powder is indicated for the control of early mortality, associated with E. coli organisms susceptible to ceftiofur, in day-old turkey poults.
 
Naxcel Dosage And Administration
 
Cattle
Administer to cattle by intramuscular or subcutaneous injection at the dosage of 0.5 to 1.0 mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight (1-2 mL reconstituted sterile solution per 100 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments. Selection of dosage (0.5 to 1.0 mg/lb) should be based on the practitioner’s judgement of severity of disease (i.e., for respiratory disease, extent of elevated body temperature, depressed physical appearance, increased respiratory rate, coughing and/or loss of appetite; and for foot rot, extent of swelling, lesion and severity of lameness).
 
Swine
Administer to swine by intramuscular injection at the dosage of 1.36 to 2.27 mg ceftiofur per pound (3.0 to 5.0 mg/kg) of body weight (1 mL of reconstituted sterile solution per 22 to 37 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days.
 
Sheep
Administer to sheep by intramuscular injection at the dosage of 0.5 to 1.0 mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight (1-2 mL reconstituted sterile solution per 100 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments. Selection of dosage (0.5 to 1.0 mg/lb) should be based on the practitioner’s judgement of severity of disease (i.e., extent of elevated body temperature, depressed physical appearance, increased respiratory rate, coughing and/or loss of appetite).
 
Goats
Administer to goats by intramuscular injection at the dosage of 0.5 to 1.0 mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight (1-2 mL reconstituted sterile solution per 100 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments. Selection of dosage (0.5 to 1.0 mg/lb) should be based on the practitioner’s judgement of severity of disease (i.e., extent of elevated body temperature, depressed physical appearance, increased respiratory rate, coughing and/or loss of appetite). Pharmacokinetic data indicate that elimination of the drug is more rapid in lactating does. For lactating does, the high end of the dose range is recommended.
 
Horses
Administer to horses by intramuscular injection at the dosage of 1.0 to 2.0 mg ceftiofur per pound (2.2 to 4.4 mg/kg) of body weight (2-4 mL reconstituted sterile solution per 100 lbs body weight). A maximum of 10 mL may be administered per injection site. Treatment should be repeated at 24-hour intervals, continued for 48 hours after clinical signs have disappeared and should not exceed 10 days.
 
Dogs
Administer to dogs by subcutaneous injection at the dosage of 1.0 mg ceftiofur per pound (2.2 mg/kg) of body weight (0.1 mL reconstituted sterile solution per 5 lbs body weight). Treatment should be repeated at 24-hour intervals for 5-14 days.
Reconstituted NAXCEL Sterile Powder is to be administered to dogs by subcutaneous injection. No vial closure should be entered more than 20 times. Therefore, only the 1 gram vial is approved for use in dogs.
 
Day-old Chicks
Administer by subcutaneous injection in the neck region of day-old chicks at the dosage of 0.08 to 0.20 mg ceftiofur/chick. One mL of the 50 mg/mL reconstituted solution will treat approximately 250 to 625 day-old chicks.
 
Reconstituted NAXCEL Sterile Powder is to be administered by subcutaneous injection only. A sterile 26 gauge needle and syringe or properly cleaned automatic injection machine should be used.
 
Day-old Turkey Poults
Administer by subcutaneous injection in the neck region of day-old turkey poults at the dosage of 0.17 to 0.5 mg ceftiofur/poult. One mL of the 50 mg/mL reconstituted solution will treat approximately 100 to 294 day-old turkey poults.
 
Reconstituted NAXCEL Sterile Powder is to be administered by subcutaneous injection only.

Main Ingredients

Each mL of the reconstituted drug contains ceftiofur sodium equivalent to 50 mg ceftiofur. The pH was adjusted with sodium hydroxide and monobasic potassium phosphate.

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