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Prascend Tablets 1 mg Rx

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Product Overview

How To Use

What’s in it?

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Questions & Answers

Product Description

Prascend® uses pergolide to reduce symptoms and signs of Cushing's disease, otherwise known as pituitary pars intermedia dysfunction.

What is Prascend Tablets 1 mg?

Prascend Tablets effectively reduce the signs and symptoms of cushings disease in horses (Pituitary Pars Intermedia Dysfunction).

Who is Prascend Tablets 1 mg for?

For use in horses.

Why use Prascend Tablets 1 mg?

Prascend® is the first and only FDA-approved medication available in the United States for treating pituitary pars intermedia dysfunction (Cushing's syndrome). It works to reduce signs like abnormal hair coats and unusual fat deposits.

How does Prascend Tablets 1 mg work?

Prascend® is a potent dopamine receptor antagonist. It is a synthetic ergot derivative and it is orally-administered to horses.

Manufacturer:

Boehringer Ingelheim

Active ingredient(s):

pergolide mesylate

How is Prascend Tablets 1 mg sold?

60 Tablets 120 Tablets

What are the side effects of Prascend Tablets 1 mg?

In certain horses, the following side effects are possible:
  • Changes in behavior
  • Musculoskeletal pain
  • Skin abscesses
  • Tooth disorders
  • Heart murmur
  • Laminitis
  • Unusual weight loss
  • Lethargy
  • Colic
  • Loose stools/diarrhea
  • Lameness
  • Decrease in appetite

What special precautions are there?

Prascend® should never be crushed. Risks are present with exposure to humans. Alternatively, dissolve the tablets in water, then use a syringe to administer into the mouth of the horse, use it as a top dress on the feed, or place an undissolved tablet in a treat (such as an apple) and feed it to the horse.

What to do if overdose?

Contact your closest emergency pet hospital.

How can I store Prascend Tablets 1 mg?

Do not allow temperature to exceed 77°F (25°C)

Helpful Tips:

Speak with your veterinarian to determine if Prascend® is a good option for your horse.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.

Overview

Administer orally at a starting dose of 2.0 µg/kg once daily. Dosage may be adjusted to effect, not to exceed 4.0 µg/kg daily. Prascend Tablets should not be crushed due to the potential for increased human exposure.
The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment.


Recommended Dosage Schedule for Horses

Body Weight

Dosage 2 mcg/kg

Dosage 4 mcg/kg

300 - 749 lb

0.5 tablet

1 tablet

750 – 1,249 lb

1 tablet

2 tablets

1,250 – 1,749 lb

1.5 tablets

3 tablets

1,750 – 2,249 lb

2 tablets

4 tablets

 
Dosing should be titrated according to individual response to therapy to achieve the lowest effective dose. Dose titration is based on improvement in clinical signs associated with Pituitary Pars Intermedia Dysfunction (PPID) and/or improvement or normalization of endocrine tests (for example, dexamethasone suppression test or endogenous ACTH test). If signs of dose intolerance develop, the dose should be decreased by half for 3 to 5 days and then titrated back up in 2 mcg/kg increments every 2 weeks until the desired effect is achieved.

Main Ingredients

Prascend Tablets are rectangular light red colored, half-scored tablets containing 1 mg pergolide, as pergolide mesylate.
Pergolide mesylate is a synthetic ergot derivative and is a potent dopamine receptor agonist. The chemical name of pergolide mesylate is 8β-[(Methylthio) methyl]-6-propylergoline monomethanesulfonate.

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