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Otibiotic Ointment Rx

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Product Overview

How To Use

What’s in it?


Questions & Answers

Product Description

Otibiotic Ointment (also known as gentamicin-betamethasone-clotrimazole ointment) is intended to be used to treat chronic or acute otitis externa in canines. This is typically associated with yeast (formerly known as Pityrosporum canis, now known as Malassezia pachydermatis) as well as any bacterium with susceptibility to gentamicin.

This medication is sold in the following bottles sizes:
  • 10 gm
  • 15 gm
  • 25 gm

What is Otibiotic Ointment?

Otibiotic Ointment is indicated for the treatment of canine acute and chronic otitis externa associated with yeast and/or bacteria susceptible to gentamicin.

Who is Otibiotic Ointment for?

Otibiotic Ointment should only be administered to dogs.

Why use Otibiotic Ointment?

Otibiotic Ointment (also known as Gentamicin sulfate) is used for dogs in the treatment of bacterial or yeast ear infections.

How does Otibiotic Ointment work?

This medication, Otibiotic Ointment or Gentamicin sulfate, is what’s known as an aminoglycoside antibiotic. It is intended for the treatment of bacterium that is gram-positive or gram-negative. The analog of prednisolone, also known as Betamethasone, has slight mineral corticosteroid activity and significant corticosteroid activity.

The 17-valerate ester of betamethasone, known as Betamethasone valerate, has notable anti-pruritic and anti-inflammatory properties, making it ideal to treat corticosteroid-responsive otitis externa. It is applied topically to manage Clotrimazole.

Clotrimazole is antifungal and is broad-spectrum; it is intended for use in treating infections of the dermis. These infections are typically caused by a range of yeasts and pathogenic dermatophytes. Clotrimazole works primarily by preventing organisms from growing and dividing.


Henry Schein Animal Health

Active ingredient(s):

  • Gentamicin
  • Betamethasone
  • Clotrimazole

How is Otibiotic Ointment sold?

10 gm, 15 gm and 25 gm bottles

What are the side effects of Otibiotic Ointment?

Gentamicin or Otibiotic Ointment is what’s known as an aminoglycoside. Side effects are associated with the poor absorption of aminoglycosides in the skin. This may lead to intoxication from the prolonged topical application to a large burn or wound on the skin for an extended period of time.

This is especially true in cases of insufficient renal function. Any aminoglycoside could cause both irreversible and sometimes reversible issues like cochlear, vestibular or renal toxicity.

What special precautions are there?

  • Keep this and all medication out of children’s reach.
  • In some isolated cases, primarily geriatric dogs, Otibiotic Ointment (gentamicin-betamethasone-clotrimazole ointment) can lead to partial loss of hearing or deafness. This loss of hearing is typically only temporary in nature.
  • If this symptom associated with hearing is observed during treatment, immediately stop administering the medication and flush the ear with a solution that is non-ototoxic.
  • The administration of corticosteroids in rodents, rabbits, and dogs during gestation lead to offspring with cleft palates. Other observed anomalies in animals administered corticosteroids during pregnancy include:
    • Phocomelia
    • Deformed forelegs
    • Anasarca
    Both experimental and clinical research has shown that the oral administration of corticosteroids parenterally or orally could cause the induction of parturition in the first stage. This is primarily observed when the medication is administered during pregnancy in the final trimester. It could lead to premature parturition and then fetal death, dystocia, metritis orretained placenta.

What to do if overdose?

Contact your closest emergency pet hospital.

How can I store Otibiotic Ointment?

Store in a dry and cool environment. Between 36° and 77°F (2° and 25°C)

Helpful Tips:

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.


The external ear should be thoroughly cleaned and dried before treatment. Remove foreign material, debris, crusted exudates, etc., with suitable non-irritating solutions. Excessive hair should be clipped from the treatment area. After verifying that the eardrum is intact, instill 4 drops (2 drops from the 215 g bottle) of Otibiotic Ointment (gentamicin-betamethasone-clotrimazole ointment) twice daily into the ear canal of dogs weighing less than 30 lbs. Instill 8 drops (4 drops from the 215 g bottle) twice daily into the ear canal of dogs weighing 30 lbs or more. Therapy should continue for 7 consecutive days.

Main Ingredients

Gentamicin, Betamethasone and Clotrimazole

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Otibiotic Ointment

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