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Tildren for Horses 500 mg, 30 ml vial Rx

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Product Overview

How To Use

What’s in it?

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Questions & Answers

Product Description

Tildren is helpful in controlling the clinical signs of navicular syndrome. It is an intravenously-infused bisphosphonate drug in a sterile powder containing 250mg of mannitol USP and 500mg of tiludronic acid (tiludronate disodium).

What is Tildren for Horses 500 mg, 30 ml vial?

Tildren is indicated for the control of clinical signs associated with navicular syndrome in horses.

Who is Tildren for Horses 500 mg, 30 ml vial for?

For use in horses (ages 4 and up).

Why use Tildren for Horses 500 mg, 30 ml vial?

Tildren is useful for horses suffering from navicular syndrome.

How does Tildren for Horses 500 mg, 30 ml vial work?

This intravenously-infused bisphosphonate medication comes in a 30mL vial of sterile powder. Each vial contains 250mg of mannitol USP and 500mg of tiludronic acid (tiludronate disodium). It contains tiludronic acid sodium salt, a bisphosphonate known as tiludronate disodium. This is the hydrated hemihydrate form of tuludronic acid disodium salt.

Manufacturer:

Ceva Animal Health

Active ingredient(s):

Tiludronate Disodium

How is Tildren for Horses 500 mg, 30 ml vial sold?

500 mg, 30 ml vial

What are the side effects of Tildren for Horses 500 mg, 30 ml vial?

Potential side effects include:
  • Large colon impaction
  • Gastric ulcers
  • Fever
  • Anorexia
  • Inappetence
  • Polydipsia
  • Polyuria
  • Muscle fasciculations
  • Frequent urination
  • Hematoma or injection site swelling
  • Colic
  • Death

What special precautions are there?

  • Do not use with NSAIDs. These can cause renal toxicity. If your horse requires medical therapies, use a non-NSAID treatment. Observe an appropriate washout period between Tildren administration and NSAID withdrawal.
  • Observe your horse for four hours after infusion to rule out clinical signs of any adverse reaction, including colic. Signs of colic may last about 90 minutes, and are typically intermittent. Hand-walking your horse can resolve or improve the signs.
  • About 30-45% of horses will experience transient symptoms of colic (abdominal pain). Clinical signs are typically seen just after administration and may be related to intestinal motility alterations.
  • Not for use in breeding, lactating, or pregnant animals.
  • Not for use in horses intended for food slaughter.
  • Not for use in humans.
  • Keep this and all other medications away from children.
  • Conditions causing renal impairment can lead to an increased risk of an adverse reaction due to the fact that bisphosphonates are excreted by the kidneys.
  • Not for use in horses with a history of renal disease or impaired renal function.
  • Do not administer to horses with known mannitol or tiludronate sodium hypersensitivity.

What to do if overdose?

Contact your closest emergency pet hospital.

How can I store Tildren for Horses 500 mg, 30 ml vial?

Sterile powder (not reconstituted): Store in a dry and cool environment. 68-77° F (20-25° C). After preparation, the infusion it can be stored for up to 24 hours under refrigeration at 36-46° F (2-8° C) and shielded from light.

Helpful Tips:

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.

Overview

DOSAGE AND ADMINISTRATION
A single dose of TILDREN should be administered as an intravenous infusion at a dose of 1 mg/kg (0.45 mg/lb). The infusion should be administered slowly and evenly over 90 minutes to minimize the risk of adverse reactions.
Maximum effect may not occur until 2 months post-treatment.
 
DIRECTIONS FOR ADMINISTRATION
Do not reconstitute or mix TILDREN with calcium containing solutions or other solutions containing divalent cations such as Lactated Ringers as it may form complexes with these ions.
 
STEP 1: Preparation of the reconstituted solution (20 mg/mL). TILDREN should be reconstituted using strict aseptic technique. Remove 25 mL of solution from a 1 liter bag of sterile 0.9% Sodium Chloride Injection, USP and add it to one vial of TILDREN. Shake gently until the powder is completely dissolved. This reconstituted solution contains 20 mg of tiludronate disodium per mL. After reconstitution further dilution is required before administration.
 
STEP 2: Preparation of the solution for infusion. Using strict aseptic technique, withdraw the appropriate volume of the reconstituted solution based on the horse’s body weight (see Table 1 below). Inject that volume back into the 1 liter bag of sterile 0.9% Sodium Chloride Injection, USP. Horses greater than 1,210 lbs. will require a second vial of reconstituted TILDREN solution. Invert the infusion bag to mix the solution before infusion. Label the infusion bag to ensure proper use.
After preparation, the infusion should be administered either within 2 hours of preparation, or it can be stored for up to 24 hours under refrigeration at 36-46° F (2-8° C) and protected from light.
 
STEP 3: Administer for infusion through a suitable intravenous catheter inserted into a jugular vein and connected to the infusion bag using sterile disposable infusion tubing.

Main Ingredients

Tiludronate Disodium

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Tildren for Horses 500 mg, 30 ml vial

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