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Galliprant (Grapiprant) Flavored Tablets Rx

Galliprant (Grapiprant) Flavored Tablets are for the control of pain and inflammation associated with osteoarthritis in dogs. Galliprant (Grapiprant) is a new class of anti-inflammatory that targets pain, so your dog can get pain relief from the earliest diagnosed stages of osteoarthritis. Available in strengths of 20 mg, 60 mg and 100 mg in 1 count flavored tablets or bottles of 30 or 90. 

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What is Galliprant (Grapiprant) Flavored Tablets?

Galliprant (Grapiprant) Flavored Tablets are indicated for the control of pain and inflammation associated with osteoarthritis in dogs.

Who is Galliprant (Grapiprant) Flavored Tablets for?

Dogs (9 months of age or older weighing at least 8 lbs)

Why use Galliprant (Grapiprant) Flavored Tablets?

-Specifically blocks the EP4 receptor, the primary mediator of canine osteoarthritis pain and inflammation
-Proven effective
-No clinically significant changes in liver, kidney or coagulation parameters
-Pork/Liver flavored tabs for easy administration
-FDA approved

How does Galliprant (Grapiprant) Flavored Tablets work?

Clinical Pharmacology: Grapiprant is a prostaglandin E2 (PGE2) EP4 receptor antagonist; a non-cyclooxygenase inhibiting, non-steroidal, anti-inflammatory drug. Grapiprant has a canine EP4 receptor binding affinity (Ki) of 24 nM. Prostaglandins have a wide variety of physiologic effects. Prostaglandin E2 (PGE2) is a prostanoid that exerts its effects via four receptors, EP1, EP2, EP3, and EP4. PGE2 is involved in mediating inflammatory pain, vasodilation, increasing vascular permeability; as well as gastrointestinal homeostasis, renal function and reproductive functions. The EP4 receptor is important in mediating pain and inflammation as it is the primary mediator of the PGE2 elicited sensitization of sensory neurons1 and PGE2 elicited inflammation.2 Grapiprant blocks PGE2 -elicited pain and inflammation by antagonizing the EP4 receptor. The EP4 receptor, along with the EP1, EP2 and EP3 receptors, is involved in PGE2 mediated effects on gastrointestinal homeostasis and renal function. PGE2 effects mediated solely by the EP4 receptor are stimulation of mucus secretion in the stomach and large intestine, stimulation of acid secretion in the stomach, inhibition of small intestine motility and inhibition of cytokine expression in the large intestine.3 While PGE2 gastroprotective action is mediated by EP1, the healing-promoting action of PGE2 in the stomach is mediated by the EP4 receptor.4 In the kidney, the PGE2 antinatiuretic effect is mediated by the EP4 receptor.5 EP4 receptors are abundantly expressed in the heart of dogs,6 the clinical relevance of which is unknown. The EP4 receptor is not involved in generation of pyrexia. Grapiprant is not a potential inhibitor of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 mediated metabolism pathways. Grapiprant is a substrate of P-glycoprotein transport. In vitro metabolism with dog liver microsomes identified two oxidative metabolites, M3 (hydroxyl) and M5 (N-dealkylation).


Elanco / Aratana

Active ingredient(s):


How is Galliprant (Grapiprant) Flavored Tablets sold?

20 mg, 60 mg and 100 mg strengths in 1 count flavored tablets or bottles of 30 or 90

What are the side effects of Galliprant (Grapiprant) Flavored Tablets?

Adverse reactions in dogs receiving GALLIPRANT may include vomiting, diarrhea, decreased appetite, mucoid, watery or bloody stools, and decreases in serum albumin and total protein.

What special precautions are there?

Warnings: Not for use in humans or cats, only for dogs. Keep this and all medications out of reach of children and pets. Consult a physician in case of accidental ingestion by humans. Keep out of reach of dogs and other pets in a secured location in order to prevent accidental ingestion or overdose. Dogs should not take GALLIPRANT if : Your dog is presently taking aspirin, other NSAIDs, or corticosteroids (unless directed by your veterinarian). Your dog has had an allergic reaction (such
as hives, facial swelling, or itchy skin) to GALLIPRANT. Inform your veterinarian if your dog has had an allergic reaction to other anti-inflammatory drugs. Your dog is under 8 pounds in body weight.

What to do if overdose?

Contact your nearest emergency animal hospital

How can I store Galliprant (Grapiprant) Flavored Tablets?

Store at or below 86° F (30° C)

Helpful Tips:

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.
Use as directed by your Veterinarian. 


Dose                      -                     Weight (lbs)   /  Weight (kg)  /  20-mg tablet  /  60-mg tablet  /  100-mg tablet
0.9 mg/lb (2 mg/kg) once daily       8-15             3.6-6.8                  0.5  
                                                            15.1-30     6.9-13.6            1  
                                                            30.1-45    13.7-20.4                            0.5  
                                                            45.1-75     20.5-34                              1  
                                                           75.1-150     34.1-68                                                1
                                                          150.1-220     68.1-100                                                2

**Dosage should be calculated in half-tablet increments. Dogs weighing less than 8 lbs (3.6 kg) cannot be accurately dosed.

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2 Questions | 1 Answers
Questions With Most helpful Answers?

Should Galliprant be given with food?1 Answer

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Should Gallaprant be taken with food?0 Answer

Should Gallaprant be taken with food?0 Answer

1 Years 6 Months 1 Weeks ago

Should Galliprant be given with food?1 Answer

I can find no mention of with food or without- does anyone know?
1 Years 5 Months 5 Days ago
, From NC


According to the manufacturer, Galliprant (Grapiprant) flavored tablets should not be mixed in with the food. This information is accurate at the time that this reply was written. This medication requires a prescription from a veterinarian. Please consult with your veterinarian before administering. Use as directed..
1 Years 5 Months 5 Days ago
Allivet Contributor
Thank you for your feedback.

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