Sentinel Spectrum vs Simparica Trio

One of the most important parts of being a dog parent is keeping your pup healthy throughout his or her life. Choosing the right parasite and heartworm prevention can be tough because there are so many top-quality products available on the market today. Two of the most popular formulas are Sentinel Spectrum and Simparica Trio. Each product has a unique set of advantages and features, which we’ve outlined below. This information should be helpful when you’re choosing the best product for your specific dog!

Sentinel Spectrum for Dogs

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Simparica Trio

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How does Sentinel Spectrum differ from Simparica Trio?

At a glance, these two medications might appear pretty similar. After all, they both protect dogs against heartworms, roundworms, hookworms, and fleas. They are both chewable, beef-flavored tablets, they each require a prescription, and they are both administered monthly. 

They’re also both safe for use in puppies - Sentinel Spectrum is safe for use in puppies from an age of 6 weeks and a weight of 2 pounds, while Simparica Trio can be safely given to puppies weighing 2.8 pounds with a minimum age of 8 weeks. However, that’s where the parallels between these two formulas end.

Sentinel Spectrum contains three active ingredients - Praziquantel, Milbemycin Oxime, and Lufenuron. In addition to the parasites listed above, these ingredients provide a defense against whipworms, and they work to stop the development of flea eggs and larvae. This product is safe for use in pregnant, lactating, or breeding dogs.

Simparica Trio contains a trio of ingredients as well - Pyrantel, Moxidectin, and Saroloner. This medication provided added protection against ticks, flea larvae, and flea eggs. It should not be used in pregnant, lactating, or breeding animals because it has not been evaluated for safety under these conditions.

Final thoughts on Sentinel Spectrum vs. Simparica Trio

When choosing between these two formulas, think about your dog and his or her individual needs. Do you have a puppy between 2 and 2.8 pounds, a puppy between 6 and 8 weeks of age, or a pregnant, lactating, or breeding dog? If so, Sentinel Spectrum is the safest option. Is your dog prone to whipworms? If so, Sentinel Spectrum is a great way to keep this problem at bay.

It’s also important to think about flea and tick protection. Every dog should be taking a flea and tick preventative to keep them healthy and happy year-round. Is your dog already taking a flea and tick treatment? If so, ask your vet if Sentinel Spectrum is a good option, or if another medication might be better suited for your dog’s needs. If your dog isn’t already protected against these potentially dangerous parasites, Simparica Trio is an excellent, broad-spectrum solution.

Talk to your veterinarian about these and any other medications you’re considering for your dog. Your vet is your best ally when it comes to keeping your dog healthy. If you think of any other questions or concerns about any Allivet product, simply reach out to our pharmacists for a pet parent consultation!

Feature Sentinel Spectrum Simparica Trio
Kills Fleas No Yes
Repels Fleas No No
Kills Flea Eggs and Larvae Stops Development Yes
Kills Ticks No Yes
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes Yes
Other Parasites Roundworm, Hookworm, and Whipworm Hookworms and Roundworms
Waterproof Yes since taken orally Yes
How Long to work N/A N/A
Taste Beef Flavored Beef Flavored
Active Ingredient Milbemycin Oxime, Lufenuron, and Praziquantel Sarolaner, Moxidectin, and Pyrantel
RX Required Yes Yes
Application Type Chewable Tablet Chewable Tablet
Dosing 1 tablet per month 1 tablet per month
Age Dogs aged 6 weeks and weigh 2lbs or more Dogs 8 weeks and 2.8lbs or more
Manufacturer Merck Animal Health Boehringer Ingelheim
Safety Breeding, pregnant, and lactating dogs may use. Has not been evaluated in breeding, pregnant, or lactating dogs.

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