Simparica Trio vs Heartgard Plus

Keeping family healthy is a top priority, and your furry family members are no exception! Choosing the best parasite and heartworm preventative is one of the most effective ways to keep your dog healthy and happy. Simparica Trio and Heartgard Plus are two of the best products on the market today. While each formula boasts reliable and safe protection, there are some important differences that can help you choose between the two. The table and information that follow are designed specifically to help you with this important decision!

Simparica Trio

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Heartgard Plus

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Tips for choosing between Simparica Trio and Heartgard Plus

First, let’s highlight the many similarities between these two products. Chief among these parallels is that both products protect dogs against heartworms, roundworms, and hookworms. They both offer a chewable, beef-flavored tablet, they are both administered monthly, and they both require a prescription. They are also both safe for use in puppies. Simparica Trio can be administered to puppies over 2.8 pounds and 8 weeks old, while Heartgard Plus is safe from an age of 6 weeks.

Heartgard Plus contains two active ingredients - Ivermectin and Pyrantel Pamoate. This product is safe for use in pregnant or breeding dogs. Simparica Trio offers three active ingredients - Moxidectin, Pyrantel, and Saroloner. Together, these ingredients defend dogs against the parasites mentioned above, but they also work to kill fleas in the adult, larval, and egg stages. They also eliminate ticks. Simparica Trio has not been proven safe for use in pregnant, lactating, or breeding dogs.

Neither formula is safe for use in cats. However, Heartgard for Cats is a great option for your feline friend.

Key takeaways on Simparica Trio vs. Heartgard Plus

If you’re still unsure about which of these medications would be the best choice for your dog, thinking about their differences can be helpful. If you have a breeding dog, a pregnant dog, or a puppy between 6 and 8 weeks old, Heartgard Plus is the safest option. If you’re hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner. However, if your dog is already taking a flea and tick preventative, your vet might suggest concomitant use of Heartgard Plus.

Mention these products to your veterinarian, and be sure to bring up any concerns you might have before getting your pet’s prescription. After filing your dog’s prescriptions conveniently at Allivet, you might think of additional questions. That’s what our pharmacists are here for! Don’t hesitate to reach out for a free pet parent consultation.

Feature Simparica Trio Heartgard Plus
Kills Fleas Yes No
Repels Fleas No No
Kills Flea Eggs and Larvae Yes No
Kills Ticks Yes No
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes Yes
Other Parasites Hookworms and roundworms Hookworms and roundworms
Waterproof Yes since taken orally Yes
How Long to work N/A N/A
Taste Beef flavored Beef flavored
Active Ingredient Sarolaner, Moxidectin, and Pyrantel Ivermectin and Pyrantel Pamoate
RX Required Yes Yes
Application Type Chewable Tablet Soft Chew
Dosing 1 tablet per month 1 soft chew per month
Age Dogs 8 weeks and 2.8lbs or more Dogs 6 weeks and older
Manufacturer Boehringer Ingelheim Boehringer Ingelheim
Safety Has not been evaluated in breeding, pregnant, or lactating dogs. Safe for pregnant or breeding females.

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