Trifexis vs Advantage Multi

Your pet’s health and happiness is a top priority. At Allivet, we believe that finding the right medications for your pet is important. Your time is important, too! That’s why we’ve created a comparison chart between Trifexis Chewable Tablets and Advantage Multi. While both of these options would be an effective way to protect your pet, there are some key differences to consider. Keep reading to learn more!

Trifexis Chewables for Dogs

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Advantage II for Dogs

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What are the differences between Trifexis and Advantage Multi

The most glaring difference between these two products is administration. Trifexis is an oral medication with a beef flavor, which your pet may enjoy as a treat. Advantage Multi is applied topically. With Advantage Multi, you can start your pet as early as 7 weeks and 3 pounds. Trifexis is safely administered at 8 weeks and 5 pounds.

Trifexis contains Spinosad and Milbemycin Oxime, and it begins to kill fleas in as little as 30 minutes. It eliminates all fleas within 4 hours. Advantage Multi uses Imidacloprid and Moxidectin. It starts to kill fleas in 12 hours. Both products eliminate internal parasitic infestations such as roundworm, hookworm, whipworm. They also prevent heartworm. Advantage Multi has the added benefit of eliminating ear mites.

Both products are safe for dogs when used as directed. Speak to your vet about the risks associated with using Advantage Multi in pregnant or lactating dogs. Trifexis has not yet been evaluated for use in breeding, pregnant, or lactating dogs. Although Trifexis is not available for cats, Advantage Multi comes in a feline formula.

Trifexis and Advantage Multi require a prescription from your veterinarian. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog.

Final Thoughts on Trifexis vs Advantage Multi

Overall, the costs for Trifexis and Advantage Multi are comparable. Some pet owners may prefer the ease of applying the medication topically instead of making sure their pet consumes Trifexis. Certain pet parents may switch to Trifexis for quicker relief. You might also choose to switch to an alternative product to protect breeding, pregnant, and lactating dogs.

If you still have questions on which oral flea and tick treatment is best for your furry friend, our pharmacists are standing by to offer pet parent consulting.

Feature Trifexis Advantage Multi
Kills Fleas Yes Yes
Repels Fleas No No
Kills Flea Eggs and Larvae Yes No
Kills Ticks No No
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes Yes
Other Parasites Roundworm, hookworm, and whipworm Ear mites, roundworms, and hookworms
Waterproof Yes since taken orally Yes
How Long to work Kills 100% of biting fleas in 4 hours Begins to kill fleas within 12 hours
Taste Beef Flavored N/A
Active Ingredient Spinosad and Milbemycin Oxime Imidacloprid and Moxidectin
RX Required Yes Yes
Application Type Chewable Tablet Topical
Dosing 1 tablet per month 1 application per month
Age Puppies 8 weeks and older and weigh more than 5 lbs. Dogs 7 weeks and older that weight at least 3 pounds
Manufacturer Elanco Animal Health Bayer Animal Health
Safety Not yet evaluated for use of in breeding, pregnant, or lactating dogs. Speak to your vet about risks associated with breeding, pregnant, or lactating dogs

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