For the prevention of heartworm disease, Revolution must be administered monthly, preferably on the same date each month. If a dose is missed and over 30 days have gone by since the last dose, give Revolution immediately and resume the monthly dosing schedule.
Revolution may be given year round or only during the mosquito season. If given seasonally, the first dose must be given within 30 days of the dog's first exposure to mosquitoes. The last dose must be given within 30 days after the dog's last exposure to mosquitoes.
We recommend you test your pet for heartworm infection before starting a preventive program.
Reminder stickers are included to place on your calendar for each of the months following the date of the first dose.
Switching Heartworm Preventives: If Revolution replaces another type of heartworm preventive, the first dose must be given within 30 days after the last dose of the previous product.
Flea Control: For the prevention and control of flea infestations, Revolution should be administered at monthly intervals throughout the flea season, starting one month before fleas become active.
Ear Mite Treatment: For the treatment of ear mite (O. cynotis) infestations, Revolution should be administered once as a single topical dose. A second monthly dose may be required in some animals. Monthly use of Revolution will control any subsequent ear mite infestations. Cleansing of the infested ears is recommended to remove the debris.
Sarcoptic Mange Treatment for Dogs: For the treatment of sarcoptic mange (S. scabiei) in dogs, Revolution should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolution will control any subsequent sarcoptic mange mite infestations.
Tick Control for Dogs: For the control of tick (Dermacentor variabilis) infestations in dogs, Revolution should be administered on a monthly basis. In heavy tick infestations, complete efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter.
Puppies: (6 weeks of age or older)
Up to 5 lbs Apply contents of 1 tube once a month (Mauve Box)
5.1-10 lbs Apply contents of 1 tube once a month (Purple Box)
10.1-20 lbs Apply contents of 1 tube once a month (Brown Box)
20.1-40 lbs Apply contents of 1 tube once a month (Red Box)
40.1-85 lbs Apply contents of 1 tube once a month (Teal Box)
85.1-130 lbs Apply contents of 1 tube once a month (Plum Box)
Over 130 lbs Use the appropriate combination of tubes
Selamectin, the active ingredient in REVOLUTION, is a macrocyclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using REVOLUTION beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of age), or gaps of >2 months in the administration of REVOLUTION during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of REVOLUTION may be harboring pre-patent infections at the time REVOLUTION was started.
Testing such animals 3-4 months after initiation of REVOLUTION would be necessary to confirm their negative heartworm status.