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Heartgard Plus Chewables For Dogs Rx

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Product Overview

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Questions & Answers

Product Description

HEARTGARD® Plus (ivermectin/pyrantel) is a monthly chewable given to your dog that’s formulated to kill heartworms as well as help treat and control hookworms. An infected mosquito that bites your dog can potentially lead to permanent damage in less than three months. That’s why it’s important to keep your dog on a monthly heartworm preventative year-round. Before treating your dog, make sure they have a current annual heartworm test result on file with your vet. HEARTGARD Plus is safe to use in all dogs aged 6 weeks and older regardless of weight. Regular dosing is recommended by the American Heartworm Society as an easy way to protect your dog throughout the year. Don’t forget, it’s important to talk to your veterinarian about any other drugs your pet is taking before starting HEARTGARD Plus. Checkout the Allivet Heartworm Comparison chart to compare heartworm prevention products.

What is Heartgard Plus Chewables For Dogs?

Heartgard Plus is a real beef chewable that prevents heartworm disease and treats and controls roundworms and hookworms in dogs.

Who is Heartgard Plus Chewables For Dogs for?

For dogs and puppies 6 weeks of age and older.

Why use Heartgard Plus Chewables For Dogs?

#1 Vet-recommended heartworm preventive. Effectively prevents heartworms. Dogs (6+ weeks of age, no weight requirement). Also treats and controls roundworms & hookworms. Only given once a month. Delicious real-beef chew that dogs love.

How does Heartgard Plus Chewables For Dogs work?

Heartgard contains two active ingredients that work together to prevent heartworm disease and treat and control hookworms and roundworms.


Boehringer Ingelheim

Active ingredient(s):

Ivermectin and Pyrantel Pamoate

How is Heartgard Plus Chewables For Dogs sold?

Heartgard Plus is sold in either a 6 or 12 month supply/chewables. Each box is color coded for your dog's weight as follows : Heartgard Plus Blue: 1-25 lbs, Heartgard Plus Green: 26-50 lbs, Heartgard Plus Brown: 51-100 lbs.

What are the side effects of Heartgard Plus Chewables For Dogs?

In clinical field trials with HEARTGARD Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.

What special precautions are there?

Keep away from children and animals. HEARTGARD® Plus (ivermectin/pyrantel) is well tolerated. All dogs should be tested for heartworm infection before starting a preventive program. Following the use of HEARTGARD Plus, digestive and neurological side effects have rarely been reported.

What to do if overdose?

Contact the closest emergency pet hospital.

How can I store Heartgard Plus Chewables For Dogs?

Store between 68° - 77°F. Protect product from light.

Helpful Tips:

Remember to not only eliminate fleas from your dog, but to treat other animals in the house as well as treat areas such as carpets and yards for flea infestations.
It's advised to not feed your dog rodents or uncooked meat or fish.
To prevent reinfection, daily cleanup of stools is recommended.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.


Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find HEARTGARD Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. HEARTGARD Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes. When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of HEARTGARD Plus must be given within a month (30 days) of the last dose of the former medication. If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD Plus and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms. Monthly treatment with HEARTGARD Plus also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

Main Ingredients

Heartgard Plus Chewables are manufactured by Merial and contain the active ingredients ivermectin and pyrantel: 

Active Ingredients/Amount per Tablet:
Heartgard Blue Chewables (1 - 25 lbs) - 68 mcg ivermectin 57 mg pyrantel 
Heartgard Green Chewables (26 - 50 lbs) - 136 mcg ivermectin 114 mg pyrantel 
Heartgard Brown Chewables (51 - 100 lbs) - 272 mcg ivermectin 227 mg pyrantel

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Heartgard Plus Chewables For Dogs

Frequently Asked Questions about Heartgard Plus

What is difference between Heartgard and Heartgard Plus?

Does Heartgard Plus require a prescription?

Does Heartgard Plus kill fleas and ticks?

How fast does Heartgard Plus work?

Can you skip a month of heartworm medicine?

Can Heartgard and Nexgard be given at the same time?

Will Heartgard kill existing worms?

Do I need to give my dog heartworm medicine in the winter?

Can Heartgard kill a dog?

When do I give Heartgard Plus?

Can Heartgard Plus be cut in half?

Can Heartgard Plus cause diarrhea?

Can Heartgard Plus cause seizures?

Does Heartgard Plus kill tapeworms?

Does Heartgard Plus kill whipworms?

Will Heartgard Plus kill roundworms?

Is Heartgard Plus safe for pregnant dogs?

Is Heartgard Plus safe for nursing dogs?

Is Heartgard Plus safe for puppies?

Customer Submitted Questions

Is Heartgard made in America?

1 Answer

What is the expiration date? More than 12 months out?

1 Answer

Does Heartguard Plus require a prescription?

1 Answer
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