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Sentinel Rx

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Product Overview

How To Use

What’s in it?



Questions & Answers

Product Description

Sentinel Flavor Tabs help prevent heartworm disease, prevent and control flea populations, control of adult hookworms, and remove and control adult roundworm and whipworm infections. Sentinel is recommended for use in dogs and puppies four weeks of age and older. See the Allivet Heartworm Comparison chart to find which heartworm prevention is best for your pet.

What is Sentinel?

Sentinel (milbemycin oxime/lufenuron) Flavor Tabs are chewable tablets manufactured by Virbac that control flea populations and adult hookworms, and remove and control adult roundworm and whipworm infections in dogs and puppies. In addition Sentinel helps prevent heartworms.

Who is Sentinel for?

Sentinel may be used for dogs and puppies four weeks of age or older.

Why use Sentinel?

Sentinel is a beef-flavored, monthly chewable tablet for dogs that provides protection for multiple types of infestations and infections. These oral preventatives: -Control flea infestations -Prevent heartworm disease -Treat and control roundworms -Treat and control whipworms -Treat heartworm and protect against infestations

How does Sentinel work?

The active ingredients in Sentinel, milbemycin oxime and lufenuron, work to eliminate worm infestations and control flea populations. Milbemycin oxime is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxocara canis and Toxascaris leonina) and whipworm (Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. Concurrent use of an adulticide product may be necessary for adequate control of adult fleas.



Active ingredient(s):

Milbemycin Oxime - Lufenuron

How is Sentinel sold?

Sentinel is available in four tablet sizes in color-coded packages for oral administration to dogs and puppies according to their weight (see How to Use). Each tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 4.55 mg/pound (10 mg/kg) body weight of lufenuron.

What are the side effects of Sentinel?

Sentinel may result in the following side effects: depression, lethargy, vomiting, staggering, loss of appetite, diarrhea, seizures or drooling.

What special precautions are there?

Sentinel should not be used in puppies less than four weeks of age or less than two pounds of body weight. Have your dog tested for existing heartworm infections prior to administration of Sentinel.

What to do if overdose?

In case of overdose, contact your nearest emergency animal hospital.

How can I store Sentinel?

Store Flavor Tabs at room temperature. Keep these tablets and all drugs out of the reach of children.

Helpful Tips:

Sentinel Flavor Tabs may be used concurrently with Capstar (nitenpyram) Tablets to provide a Flea Management System that kills mature fleas and prevents flea eggs from hatching. Please see the Supplemental Package Insert provided with this product for information about concurrent use of the two products.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.

Sentinel is given orally, once a month, at the recommended minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime and 4.55 mg/lb (10 mg/kg) lufenuron. Please see separate insert in this package for concurrent dosing of Sentinel Flavor Tabs and Capstar Tablets.

Flavor Tabs are palatable and most dogs will consume the tablet when offered by the owner. If you are having trouble getting your dog to eat the tablets, they can be hidden in food as an alternative to direct dosing. Make sure dog consumes the entire tablet or tablets. 

Administer Flavor Tabs immediately after or in conjunction with a normal meal. Food is essential for adequate absorption of lufenuron. Watch your dog closely following administration to be sure the entire dose has been consumed. If it is not entirely consumed, redose with the full recommended dose as soon as possible. 
Sentinel Flavor Tabs must be administered monthly, preferably on the same date each month. Treatment may begin at any time of year. In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until the end of “mosquito and flea season.” In areas with year-round infestations, treatment should continue through the entire year without interruption.
Sentinel for Flea Control
Give your Flavor Tabs once per month to prevent and control flea populations. Sentinel Flavor Tabs contain lufenuron. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill mature fleas. If a dog currently has a flea infestation, more rapid relief can be accomplished by adding Capstar. Capstar Tablets contain nitenpyram and are effective for the treatment of flea infestations. Nitenpyram starts killing adult fleas within 30 minutes of administration. Administer the treatment as follows:
- Give your dog Capstar Tablets once per week until adult fleas are no longer observed.
- For a severe flea infestation, administer Capstar Tablets twice per week until adult fleas are no longer observed.
- Additional Capstar Tablets may be administered as needed to kill the occasional adult flea picked up from infested environments.
- It is important to treat all cats and dogs in the household. All cats should be treated with approved products like lufenuron in combination with nitenpyram as needed. Fleas can reproduce on untreated pets and allow infestations to persist.
The combination of Sentinel Flavor Tabs and Capstar Tablets should be administered according to the following schedule. Weigh your dog prior to administration to ensure proper dosage. Do not administer to dogs under 2 pounds or less than 4 weeks of age.
Administer with a normal meal.

Recommended Dosage Schedule: 
Dog’s Weight  /  Milbemycin Oxime Per Tablet  /  Lufenuron Per Tablet
2 to 10 lbs.    /                  2.3 mg                   /                46 mg
11 to 25 lbs. /                   5.75 mg                 /               115 mg
26 to 50 lbs. /                  11.5 mg                 /                230 mg
51 to 100 lbs. /                23 mg                   /                 460 mg
For dogs over 100 pounds give the appropriate combination of tablets.

The active ingredients present in Sentinel Flavor Tabs are milbemycin oxime and lufenuron.

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3 Questions 3 Answers

Questions With Most helpful Answers?

What happens if my dog's weight is in between

1 Answer

is sentinel the only tablet I HAVE to give my dog ...since its for heartworm prevention and also controls flea population?

1 Answer

Does this product prevent BOTH heartworm & Flea & Tick?

1 Answer
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