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Advantage Multi for Dogs Rx

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Product Overview

How To Use

What’s in it?


Questions & Answers

Product Description

Advantage Multi for Dogs® is a monthly topical solution that prevents heartworm disease; controls parasites in the intestines, including whipworm, roundworm, and hookworm; treats infestation of fleas; and kills adult fleas. See the Allivet Heartworm Comparison chart to find which heartworm prevention is best for your pet.

What is Advantage Multi for Dogs?

Advantage Multi for dogs is a Once-a-month topical solution for the prevention of heartworm disease, kills adult fleas, is indicated for the treatment of flea infestations, as well as the treatment and control of intestinal parasite infections.

Who is Advantage Multi for Dogs for?

For use in puppies (ages 7 weeks and up; 3 pounds and up) and dogs.

Why use Advantage Multi for Dogs?

Advantage Multi for Dogs® is an all-in-one monthly treatment for the prevention of heartworms, parasites, and fleas.

How does Advantage Multi for Dogs work?

Advantage Multi for Dogs® is a ready-to-use single-dose topical solution. The solution comes in an applicator tube and may be colorless or yellow. The dosage schedule and dosage formulation are intended to provide at least 4.5 mg/lb (10 mg/kg) of imidacloprid and 1.1 mg/lb (2.5 mg/kg) of moxidectin, based on body weight.


Bayer Animal Health

Active ingredient(s):

10% imidacloprid
2.5% moxidectin

How is Advantage Multi for Dogs sold?

A prescription is required. Sold in 3, 6 or 12 month color coded boxes according to your dog's weight.
  • Green: 3 - 9lb dogs
  • Teal: 9.1 - 20 lbs dogs
  • Red: 20.1 - 55 lbs dogs
  • Blue: 55.1 - 88 lbs dogs
  • Brown: 88.1 - 110 lbs dogs

What are the side effects of Advantage Multi for Dogs?

The following side effects are possible with topical treatment in dogs:
Hair discoloration at application site, Local discomfort, Hot spots, Alopecia, Erythema (skin redness), Pruritus (itching), Swollen ears and face, Rash, Hives, Acute pulmonary edema, Labored breathing, Panting, Seizures, Muscle tremors, Ataxia (impaired coordination), Disorientation, Agitation, Restlessness, Weakness, Lethargy, Poor appetite, Salivation, Diarrhea or bloody diarrhea, and Vomiting

The following side effects are possible with accidental oral ingestion in dogs:
Poor appetite, Agitation, Disorientation, Lethargy, Ataxia (impaired coordination), Mydriasis (dilated pupils), Seizures, Muscle tremors, Vomiting, and Salivation.

The following side effects are possible with topical treatment in cats:
Neurologic signs, Agitation, Lethargy, Vomiting, Skin or application site reactions.

What special precautions are there?

  • Accidental ingestion by dogs can result in serious side effects, including generalized muscle tremors, panting, incoordination, dilated pupils, salivation, or depression. In dogs sensitive to avermectin, the side effects can be more serious and could include coma or death.
  • For 30 minutes following treatment, make sure that dogs can't lick the application sites on other treated dogs or themselves. Separate dogs from one another after treatment to minimize accidental ingestion risk.

What to do if overdose?

In case of overdose, contact your closest pet hospital

How can I store Advantage Multi for Dogs?

Avoid excessive cold or heat. Store at temperatures between 4°C (39°F) and 25°C (77°F).

Helpful Tips:

Not for use in cats.(contains 2.5% moxidectin).

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.


The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. Do not apply to irritated skin.

1. Remove one dose applicator tube (tube) from the package. As specified in the following table, administer the entire contents of the Advantage Multi® for Dogs tube that correctly corresponds with the body weight of the dog.

Dog (lbs.)

Advantage Multi For Dogs

Volume (mL)

Imidacloprid (mg)

Moxidectin (mg)

3 - 9

Advantage Multi 9




9.1 - 20

Advantage Multi 20




20.1 - 55

Advantage Multi 55




55.1 - 88

Advantage Multi 88




88.1 - 110*

Advantage Multi 110





* Dogs over 110 lbs. should be treated with the appropriate combination of Advantage Multi for Dogs tubes.

Main Ingredients

(imidacloprid + moxidectin)

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Advantage Multi for Dogs

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