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Trifexis Chewable Tablets for Dogs Rx

Trifexis for Dogs is a monthly chewable tablet for dogs that kills fleas, prevents heartworm disease, and treats and controls adult hookworm, whipworm and roundworm infections. See the Allivet Heartworm Comparison chart to find which heartworm prevention is best for your pet. 

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What is Trifexis Chewable Tablets for Dogs?

Trifexis for dogs is a monthly chewable pill that provides flea control and parasite protection against heartworm, roundworm and intestinal worms.

Who is Trifexis Chewable Tablets for Dogs for?

Trifexis is for dogs and puppies 8 weeks or older. Trifexis should not be used on puppies or dogs under 5 lbs body weight.

Why use Trifexis Chewable Tablets for Dogs?

-Trifexis Kills fleas before they can lay eggs
-Trifexis Begins killing biting fleas within 30 minutes
-Trifexis is beef-flavored, so you can offer it as a treat.
-Trifexis is an easy to administer chewable tablet
-Trifexis treats and controls roundworms, hookworms, and whipworms
-Trifexis will kill the immature heartworms the dog was exposed to in the preceding month.
-Trifexis prevents heartworm disease
-Trifexis does not kill ticks

How does Trifexis Chewable Tablets for Dogs work?

Trifexis prevents flea infestations and protects against parasites with one monthly chewable tablet. The main ingredient in Trifexis is Spinosad. The spinosad in Trifexis prevents and controls flea infestations by killing adult fleas The primary target of action of spinosad is an activation of nicotinic acetylcholine receptors (nAChRs) in insects. Spinosad, the active ingredient in Trifexis starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours.
Milbemycin oxime is the other active ingredient in Trifexis. Milbemycin is used to prevent heartworms. Milbemycin oxime kills adult hookworms, roundworms and whipworms. It kills the immature form of the heartworm (Dirofilaria immitis), which is transmitted to dogs by a mosquitos.
Trifexis will treat an intestinal infection with adult hookworms, roundworms, and whipworms, and will kill adult fleas.

Generic Brands:

Spinosad and Milbemycin Oxime


Elanco Animal Health

Active ingredient(s):

Spinosad and Milbemycin Oxime

How is Trifexis Chewable Tablets for Dogs sold?

Trifexis Pink 1 Month Supply for dogs 5 - 10 lbs
Trifexis Orange 1 Month Supply for dogs 10.1 - 20 lbs
Trifexis Green 1 Month Supply for dogs 20.4 - 40 lbs
Trifexis Blue 1 Month Supply for dogs 40.1 - 60 lbs
Trifexis Brown 1 Month Supply for dogs 60.1 - 120 lbs

Trifexis Pink 6 Month Supply for dogs 5 - 10 lbs
Trifexis Orange 6 Month Supply for dogs 10.1 - 20 lbs
Trifexis Green 6 Month Supply for dogs 20.4 - 40 lbs
Trifexis Blue 6 Month Supply for dogs 40.1 - 60 lbs
Trifexis Brown 6 Month Supply for dogs 60.1 - 120 lbs

Trifexis Pink 12 Month Supply for dogs 5 - 10 lbs
Trifexis Orange 12 Month Supply for dogs 10.1 - 20 lbs
Trifexis Green 12 Month Supply for dogs 20.4 - 40 lbs
Trifexis Blue 12 Month Supply for dogs 40.1 - 60 lbs
Trifexis Brown 12 Month Supply for dogs 60.1 - 120 lbs Brown

What are the side effects of Trifexis Chewable Tablets for Dogs?

The most common adverse reactions recorded in clinical trials were vomiting, pruritus, lethargy and diarrhea. If vomiting occurs within an hour after administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting.

What special precautions are there?

Your dog should be tested for heartworm infection before starting Trifexis.
The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

What to do if overdose?

Contact your nearest emergency animal hospital in the event of adverse reaction while using Trifexis.

How can I store Trifexis Chewable Tablets for Dogs?

Store Trifexis at room temperature (68-77° F)

Helpful Tips:

Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females.

Trifexis is an oral medication and does not require you to isolate your dog from other pets during treatment.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.
Trifexis is a prescribed pet medication for the prevention of fleas and parasites such as roundworm, hookworm and heartworm. Follow your veterinarian's directions on when to give this medication. If advised to give it seasonally for heartworm prevention, remember to give it during and 3 months beyond the mosquito season, preferably on the same date each month.
Trifexis should be used as recommended by your veterinarian. If you have difficulty giving the medication, contact your veterinarian. 




Dogs (over 8 weeks of age)

5-10 lbs

1 Tab (Pink Label box)


10.1-20 lbs

1 Tab (Orange Label box)


20.1-40 lbs

1 Tab (Green Label box)


40.1- 60 lbs

1 Tab (Blue Label box)


60.1 – 120 lbs

1 Tab (Brown Label box)


Over 120 lbs

Vet’s Prescribed Dosage

If you do not administer Trifexis monthly throughout the year, the final dose must be given no fewer than three months following the last exposure to mosquitoes. Please speak with your vet for any question regarding Trifexis dosage or missed dosages. 



Trifexis for Dogs:

Active Ingredients per tablet



140 mg

Milbemycin Oxime

2.3 mg


Most pet owners have faced the challenge of ridding their homes and pets of fleas. Fleas can be a problem because they reproduce so rapidly. The persistent parasite can cause discomfort for cats, dogs and their owners. Understanding Fleas makes it easier to treat what could become a major infestation problem.

What are Fleas?

-Fleas are external pests that are capable of fast reproduction, by surviving on your pet’s blood. These tiny insects are brown in color. Although they are wingless they are able to jump reaching incredible heights. Their bodies are compressed, or flattened, from side to side. Their size make them hard to detect and much more difficult to eliminate from your pet or home. A single female flea may produce up to 2,000 eggs over her lifetime. Eggs hatch and can develop into adults within only three weeks. Adult female fleas feed by ingesting blood from your pet and subsequently lay eggs, which drop off your pet’s coat. Within days, larvae hatch from the eggs and live undetected in your pet’s surroundings, such as the carpet, bedding and other protected areas. Flea larvae spin a cocoon, and, when appropriately stimulated, a young adult flea emerges and jumps onto your pet to continue the life cycle.

Flea Life

How does my pet become Flea Infested?

-The warm and dark environment of your pet’s fur and skin provide the perfect environment and feed for fleas. A little time spent outdoors and pets easily become flea infested. Indoor cats are at risk even if they just go out on the patio. They are also at risk if they share their home with a dog or other cats.

Pets get fleas from other animals- a stray dog or cat, neighbor’s pet, or urban wildlife like opossums and raccoons may have passed through your yard while the female flea is laying eggs and the eggs are left in your pets environment. Those eggs then develop into adults and those fleas jump onto your pet.

Warning signs of Fleas

Fleas on Dogs:

-Flea droppings (dark specks) in the fur.

-Flea eggs (white specks) in the fur.

-Excessive licking or scratching.

-Scabs or hot spots on the skin.

-Allergic dermatis

-Hair loss

-Pale Gums


Fleas on Cats:

The easiest way to find fleas on a cat is to check the belly. You may see the fleas or small dark spots that move if they do not move it is possible you are viewing their droppings, which look like specks of dirt. Excessive scratching and hair loss are also signs that fleas may be feasting on your feline.

Disease Transmitted by Flea bites

Since fleas can consume 15 times their own body weight in blood, they can cause anemia or a significant amount of blood loss over time. This is especially problematic in young puppies, where an inadequate number of red blood cells can be life-threatening to some dogs. Signs of parasitic anemia include pale gums, cold body temperature and listlessness.

When a cat or dog has a heightened sensitivity to the saliva of fleas, just one bite of a flea can cause an allergic reaction. This condition is known as flea allergy dermatitis and causes intense itching and discomfort for your cat or dog. Signs include generalized hair loss, reddened skin, scabs and hot spots. Flea allergy dermatitis often leads to skin infections.

Treating Fleas

Getting rid of fleas is where the battle begins and ends once you have protected your pet from reoccurring infestation.

Flea Shampoos/Dips
1) Flea shampoos are successful at ridding your pet of adult fleas. Bathing your pet with flea shampoo will be their first source of relief from biting fleas. Follow the directions carefully. Most shampoos require you to leave the lather on your pet for 10 minutes. Check his fur CAREFULLY while bathing. Try to remove ALL of the fleas you find. Shampoos that kill the flea, rather than just remove them, are more successful. Start at your pets head and work your way down. Fleas will instinctively move to higher ground. If you start at the head you have better control of the pests and are more able to keep tabs on how well you have eradicated the fleas. Continue by working your way from the head towards the back and the chest. Bio Guard Shampoo, Adams Shampoo, ECTO-Soothe 3X Shampoo

Oral Solution
2) Treats flea infestations in dogs, puppies, cats and kittens 2lbs of body weight or greater. Capstar stops fleas from biting and kills adult fleas within 30 minutes. This is a great choice for treating outbreaks because it can be used with other flea prevention and if you still find fleas on your pet, you can administer another dose the following day. Capstar Tablets & Program Flavor Tabs for Dogs & Cats

Yard and Area
3) Treating your yard and area is an important step to treating infestations. You may rid your pets of fleas but if you do not treat the area, they will be re-infested. A treatment that kills fleas and the larvae is most efficient. Knockout Area Treatment, Virbac Yard Spray Concentrate, Frontline Spray

Flea Prevention and Control

Successful flea control must include a flea treatment that will stop the flea “cycle”. This cycle includes all life stages of the flea, the eggs, larva, pupa and adult stage.

1) Flea Collars: Moderately effective at keeping fleas off your pet and providing an unhealthy, un-welcoming environment in your pet’s fur. Breakaway Plus Flea & Tick Collar Cats, Preventic Tick Collar for Dogs, Scalibor Protector Band

2) Topical Flea Prevention: This is the first line of defense. A few carefully placed drops between the shoulder blades (to keep your pet from ingesting it) will protect your cat or dog for up to a month. Frontline Plus For Dogs, Frontline Plus Cats & Kittens, Bio-Spot , Certifect

3) Oral Flea Prevention: Oral flea prevention is often administered once a month orally. These products are noted for causing the larvae to become unable to reproduce, thus rendering an end to the life cycle. Trifexis For Dogs, Sentinel, Comfortis Chewables,

4) Natural Solutions: If you prefer a non-chemical solution, natural remedies are also available to protect your pet from fleas. Bug Off Garlic Chewables, Ectopamine Natural Flea Tick and Mosquito Topical Cat, HomeoPet Flea Bite

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1 Questions | 0 Answers
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We have a large and a small dog. Can I just order the packet for large dogs and divide one tablet into 3 pieces/doses for my smaller dog? Large dog is 90 lbs and small dog is 17 lbs.0 Answer

We have a large and a small dog. Can I just order the packet for large dogs and divide one tablet into 3 pieces/doses for my smaller dog? Large dog is 90 lbs and small dog is 17 lbs.0 Answer

1 Years 7 Months 3 Days ago

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