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Legend 10mg/ml 4ml Vial Rx

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Product Overview

How To Use

What’s in it?


Questions & Answers

Product Description

Legend is useful in treating inflammation in the joint lining and treating fetlock or carpus joint dysfunction. An injectable and FDA-approved, this medication is administered intra-articularly or intravenously in horses.

What is Legend 10mg/ml 4ml Vial?

Legend is an injectable medication used to treat inflammation of the lining of the joint and for the treatment of joint dysfunction of the carpus or fetlock in horses. The hyaluronate in Legend is thought to help regulate cells in the joint that would increase inflammation.

Who is Legend 10mg/ml 4ml Vial for?

For use in horses.

Why use Legend 10mg/ml 4ml Vial?

  • Reduces joint disease symptoms
  • Reduces joint inflammation
  • Restores the synovial fluid in the joints

How does Legend 10mg/ml 4ml Vial work?

This medication contains hyaluronate sodium. Hyaluronate molecules are long chains that form a network of fillers, which are interspersed with the normal fluids of cells. It is believed that injecting hyaluronate sodium directly into the pouch of the joint works to enhance healing of the inflamed synovium by providing restoration of the lubricating joint fluid. This supplements the normal joint fluid's visco-elastic qualities as well.


Boehringer Ingelheim

Active ingredient(s):

hyaluronate sodium

How is Legend 10mg/ml 4ml Vial sold?

Legend 10mg/ml 4ml Vial Legend 10mg/ml 4ml Box of 6 Vials

What are the side effects of Legend 10mg/ml 4ml Vial?

In clinical trials studying intra-articular and intravenous injections, no adverse systemic or local reactions were noted.

What special precautions are there?

  • Like any other intra-articular injection, precautions should be followed for sterility and careful injection technique to prevent infection or swelling. Intra-articular injections should never be administered into recently fired or blistered skin or skin with excessive counterirritant or scurf.
  • A radiographic evaluation should occur in patients with acute lameness to rule out serious fractures in the joint.
  • Safety for use in breeding animals is not proven.
  • Keep out of reach of children.

What to do if overdose?

Contact your closest emergency pet hospital.

How can I store Legend 10mg/ml 4ml Vial?

Store in a dry and cool environment. Do not exceed 104° F(40° C)

Helpful Tips:

The joint fluid contains high concentrations of hyaluronate, and it also occurs naturally within the body. The hyaluronate in this medication is believed to help regulate joint cells that can increase inflammation. After injection into the joint, hyaluronate works to help the joint lining heal and increases the joint fluid thickness. This fluid works to cushion and lubricate the joints, protecting the lining.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.


Legend® (hyaluronate sodium) Injectable Solution is indicated in the treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis.  

Legend Hyaluronate Sodium is FDA approved for use in veterinary medicine. The usual dose in horses is 4 ml (40 mg) I.V or 2ml (20 mg) intra-articular in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments.

Legend (hyaluronate sodium) Injectable Solution is a clear, colorless solution of low viscosity. Legend Injectable Solution is pyrogen free, sterile and does not contain a preservative. It is administered by intravenous or intra-articular injection.
Legend Dosage and Administration: 

Intravenous-4 mL (40 mg). Intra-articular-2 mL (20 mg) in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments.
Strict aseptic technique should be observed when administering by intra-articular injection. As with any intra-articular procedure, proper injection site disinfection and animal restraint are important. Excess joint fluid should be aseptically removed prior to injection. Care should be taken to avoid scratching the cartilage surface with the tip of the injection needle. Diffuse swelling lasting 24 to 48 hours may result from movement of the needle while in the joint space.
For intravenous administration, use aseptic technique and inject slowly into the jugular vein.
Horses should be given stall rest after treatment before gradually resuming normal activity.
Discard any unused portion of the drug and the empty vial after opening.

Main Ingredients

Hyaluronic acid, the conjugate acid of hyaluronate sodium, is extracted from the capsule of Streptococcus spp. and purified, resulting in a form which is essentially free of protein and nucleic acids.
Legend Injectable Solution is supplied in 2 mL (20 mg) vials. Each mL contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic and 0.04 mg sodium phosphate monobasic. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid.

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Legend 10mg/ml 4ml Vial

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