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Mexiletine Hydrochloride Capsule Rx

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  • Mexiletine is a class 1B sodium channel blocker. An anti-arrhythmia drug which is used to treat chronic ventricular arrhythmias in dogs. *Sold per capsule
     
     

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    What is Mexiletine Hydrochloride Capsule?

    Mexiletine is a class 1B, sodium channel blocker, anti-arrhythmia drug which is used to treat chronic ventricular arrhythmias in dogs. The mechanism of action is similar to lidocaine. Mexiletine is used to treat ventricular arrhythmias including PVC’s and ventricular tachycardia. If an animal has responded well to lidocaine during an acute episode, it is likely to respond well to mexiletine.

    Who is Mexiletine Hydrochloride Capsule for?

    Dogs

    Why use Mexiletine Hydrochloride Capsule?

    -Treats ventricular arrhythmias in dogs
    -Similar to lidocaine
    -Used to treat ventricular arrhythmias including PVC's and ventricular tachycardia
    -Mexiletine may be combined with either atenolol or sotalol in instances when monotherapy is not adequate.
    -Mexiletine may be used to treat inherited cardiomyopathy in Boxers and dilated cardiomyopathy in Doberman pinschers.
    -A positive response to therapy would be an 85% reduction of ventricular premature contractions.

    How does Mexiletine Hydrochloride Capsule work?

    Mexiletine is well absorbed orally and has a bioavailability of approximately 85%. It is primarily excreted in the urine although approximately 10% is metabolized by the liver and excreted in the feces. The half-life of this drug may be prolonged in animals with reduced cardiac output, or after an acute myocardial infarction. The half-life may also be prolonged in animals with hepatic dysfunction or severe kidney disease.

    Generic Brands:

    This is a generic medication

    Manufacturer:

    Teva

    Active ingredient(s):

    MEXILETINE HYDROCHLORIDE (MEXILETINE)

    How is Mexiletine Hydrochloride Capsule sold?

    Mexiletine is sold in single 150, 200, and 250 mg capsules.

    What are the side effects of Mexiletine Hydrochloride Capsule?

    -The most common side effects are related to the GI tract including nausea and vomiting. Giving food with mexiletine has been shown to decrease the incidence of GI side effects.
    -Other possible side effects include central nervous system signs such as dizziness, loss of balance and trembling, shortness of breath, and cardiac signs including PVCs or chest pain.

    What special precautions are there?

    Mexiletine should be used with extreme caution in animals with the following conditions: 2nd or 3rd degree AV heart block, intraventricular conduction abnormality, sinus node function abnormality, cardiogenic shock, congestive heart failure, myocardial infarction, liver dysfunction, hypotension, or seizure disorders.

    What to do if overdose?

    Overdose with mexiletine carries a significant risk of toxicity. It is reported in the human literature that central nervous system signs precede cardiovascular signs. In experimental work in dogs, a four fold overdose consistently produced CNS signs within 10 minutes of oral administration. If recognized in time, GI emptying protocol should be attempted in conjunction with urinary acidification and supportive care.

    How can I store Mexiletine Hydrochloride Capsule?

    Store in a cool and dry place

    Helpful Tips:

    Administer as recommended by your veterinarian.

    Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.
    Use as directed by your veterinarian.
    ACTIVE INGREDIENT/ACTIVE MOIETY
    Ingredient NameBasis of StrengthStrength
    MEXILETINE HYDROCHLORIDE(MEXILETINE)MEXILETINE HYDROCHLORIDE
    INACTIVE INGREDIENTS
    Ingredient NameStrength
    SILICON DIOXIDE 
    MAGNESIUM STEARATE 
    STARCH, CORN 
    FD&C YELLOW NO. 6 
    GELATIN 
    TITANIUM DIOXIDE 
    D&C RED NO. 28 
    FD&C BLUE NO. 1 
    AMMONIA 
    FERROSOFERRIC OXIDE 
    D&C YELLOW NO. 10 
    ALCOHOL 
    FD&C BLUE NO. 2 
    FD&C RED NO. 40 
    ISOPROPYL ALCOHOL 
    BUTYL ALCOHOL 
    PROPYLENE GLYCOL 
    SHELLAC 

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