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Mexiletine Hydrochloride Capsule Rx

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Product Overview

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Product Description

Mexiletine is an antiarrhythmic medication used in the treatment of ventricular arrhythmia. It is considered a class 1B sodium channel blocker.*Sold per capsule

What is Mexiletine Hydrochloride Capsule?

Mexiletine is a class 1B, sodium channel blocker, anti-arrhythmia drug which is used to treat chronic ventricular arrhythmias in dogs. The mechanism of action is similar to lidocaine. Mexiletine is used to treat ventricular arrhythmias including PVC’s and ventricular tachycardia. If an animal has responded well to lidocaine during an acute episode, it is likely to respond well to mexiletine.

Who is Mexiletine Hydrochloride Capsule for?

For use in dogs.

Why use Mexiletine Hydrochloride Capsule?

Features of Mexiletine:
  • Prescribed for the treatment of ventricular arrhythmias, including ventricular tachycardia and PVCs
  • Similar to lidocaine
  • May be used in conjunction with sotalol or atenolol when monotherapy is inadequate
  • May be used in the treatment of dilated cardiomyopathy in Doberman pinschers and in inherited cardiomyopathy in Boxers
  • 85% reduction in premature ventricular contractions indicates a positive response to therapy

How does Mexiletine Hydrochloride Capsule work?

Mexiletine offers about an 85% bioavailability and is orally well-absorbed. It is partially metabolized by the liver (10%) and excreted through the feces, and the rest is excreted through the urine. Animals who have reduced cardiac output, severe disease of the kidneys, hepatic dysfunction, or have experienced acute myocardial infarction could experience a prolonged half-life.

Manufacturer:

Teva

Active ingredient(s):

Mexiletine Hydrochloride (mexiletine)

How is Mexiletine Hydrochloride Capsule sold?

Sold by the capsule in strengths of 150mg, 200mg, and 250mg.

What are the side effects of Mexiletine Hydrochloride Capsule?

The most frequently reported adverse reactions are GI tract-related and could include vomiting or nausea. These symptoms usually improve when Mexiletine is given with food.

Other potential reactions are central nervous system-related and could include:
  • Cardiac symptoms (chest pain or PVCs)
  • Shortness of breath
  • Trembling
  • Loss of balance
  • Dizziness

What special precautions are there?

Mexiletine should be cautiously administered to animals with:
  • Seizure disorders
  • Hypotension
  • Liver dysfunction
  • Myocardial infarction
  • Congestive heart failure
  • Cardiogenic shock
  • Abnormal sinus node function
  • Abnormal intraventricular conduction
  • 2nd or 3rd degree AV heart block

What to do if overdose?

Overdose with mexiletine carries a significant risk of toxicity. It is reported in the human literature that central nervous system signs precede cardiovascular signs. In experimental work in dogs, a four fold overdose consistently produced CNS signs within 10 minutes of oral administration. If recognized in time, GI emptying protocol should be attempted in conjunction with urinary acidification and supportive care.

How can I store Mexiletine Hydrochloride Capsule?

Store in a dry and cool place.

Helpful Tips:

Follow your veterinarian's recommendations for administration.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.

Overview

Use as prescribed by your vet.

Main Ingredients

ACTIVE INGREDIENT/ACTIVE MOIETY
Ingredient NameBasis of StrengthStrength
MEXILETINE HYDROCHLORIDE(MEXILETINE)MEXILETINE HYDROCHLORIDE
INACTIVE INGREDIENTS
Ingredient NameStrength
SILICON DIOXIDE 
MAGNESIUM STEARATE 
STARCH, CORN 
FD&C YELLOW NO. 6 
GELATIN 
TITANIUM DIOXIDE 
D&C RED NO. 28 
FD&C BLUE NO. 1 
AMMONIA 
FERROSOFERRIC OXIDE 
D&C YELLOW NO. 10 
ALCOHOL 
FD&C BLUE NO. 2 
FD&C RED NO. 40 
ISOPROPYL ALCOHOL 
BUTYL ALCOHOL 
PROPYLENE GLYCOL 
SHELLAC 

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Mexiletine Hydrochloride Capsule

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