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Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe Rx

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Product Overview

How To Use

What’s in it?



Questions & Answers

Product Description

Sileo (Dexmedetomidine Oromucosal Gel) is used to treat canine noise aversion. The first and only prescription treatment approved by the FDA for this purpose, Sileo provides a low dose of dexmedetomidine. Your dog will remain calm, but still interact and function as normal.

What is Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe?

Sileo (Dexmedetomidine Oromucosal Gel) is the first and only FDA-approved prescription treatment for canine noise aversion.

Who is Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe for?

For use in dogs over the age of 16 weeks.

Why use Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe?

Features of Sileo:
  • It is an easy treatment for a condition that tends to be challenging for both the pet and the pet parent.
  • Its safety and effectiveness has been proven through a random, placebo-controlled clinical trial.
  • It acts quickly to calm your dog, but allows for normal interaction between the dog and the pet parent.
  • It calms your dog without sedating them.
  • It is easily administered at home.
  • It works independently without training or other types of treatment.

How does Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe work?

Sileo blocks a brain chemical called norepinephrine. This chemical accelerates anxiety, much like adrenaline.



Active ingredient(s):

Dexmedetomidine Hydrochloride

How is Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe sold?

Dexmedetomidine Oromucosal 0.09 mg/ml, 3 ml syringe

What are the side effects of Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe?

While uncommon, the following side effects may occur with use of Sileo:
  • Sedation
  • Drowsiness
  • Emesis (vomiting)
  • Transient pale mucous membranes at application site

What special precautions are there?

  • Keep away from children.
  • Not for human use.
  • Pregnant pet parents should not administer Sileo. Exposure could cause a decrease in fetal blood pressure or could induce uterine contractions.
  • Avoid direct exposure to the mouth, eyes, and skin when handling and using filled syringes. Wear impermeable disposable gloves when handling or administering Sileo, and when coming into contact with the dog's mouth after administering.
  • Sileo has not been tested for safe use in lactating, breeding, or pregnant dogs; in dogs with gingival or dental disease, which could alter the absorption; or in dogs under 16 weeks old.
  • Do not administer to dogs who were sedated with previous dosing.
Avoid use in dogs with the following pre-existing conditions:
  • Bradycardia
  • Hypoxia
  • Hypotension
  • Hypersensitivity to dexmedetomidine or any of the excipients
  • Conditions of stress due to fatigue or extreme cold or heat
  • Conditions of severe debilitation or shock
  • Kidney disease
  • Liver disease
  • Respiratory disease
  • Severe cardiovascular disease

What to do if overdose?

Contact your closest emergency pet hospital

How can I store Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe?

Store unopened and opened syringes in the original package at controlled room temperature 20-25°C (68-77°F) with excursions permitted to 15-30°C (59-86°F). Use syringe contents within 2 weeks after opening the syringe.

Helpful Tips:

In conjunction with Sileo, there are several easy steps you can take to modify your dog's home environment and help ease stress. These include:
  • Act normally through noise - for example, watch TV, read a book, or play with your dog.
  • Be present. Your present comforts your dog.
  • Encourage your dog to have a safe haven, such as a soundproof bathroom, closet, or basement.
  • Limit visual stimulation during fireworks by keeping the room brightly lit and closing the curtains.
  • Play music to mask scary noises. Classical music has been proven to have a calming effect in some dogs.
  • Minimize or restrict exposure to noises that scare your dog.
There are also several actions you can avoid to help your dog (and you) better cope during a noise event. These include:
  • Do not pet your dog or say "It's okay." This sends a message that it is okay to bark, pant, or pace during the noise event.
  • Do not punish your dog for damaging property or having accidents during a noise event. This makes them even more afraid of the noise. Keep in mind that they are not misbehaving. They are acting out of fear.
Always contact your veterinarian if your dog exhibits noise aversion behaviors.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.


SILEO is administered onto the oral mucosa between the dog’s cheek and gum at the dose of 125 mcg/m2. The gel is absorbed through the oral mucosa and therefore it
should NOT be swallowed. If the gel is swallowed, the product may not be effective. If the gel is swallowed, do not repeat the dose for at least two hours.
The following table provides the acceptable dosage for each weight range. Each dot (●) represents 0.25 mL of SILEO.
Each ml contains the equivalent to 0.1mg dexmedetomidine hydrochloride.
Dosage by body weight :
Bodyweight (lb)  /  Number of dots
4.4-12.1                       1 ●
12.2-26.5                     2 ●●
26.6-44.0                     3 ●●●
44.1-63.9                     4 ●●●●
64.0-86.0                     5 ●●●●●
86.1-110.2                   6 ●●●●●●
110.3-137.8                 7 ●●●●●●●
137.9-166.4                 8 ●●●●●●●●
166.5-196.2                 9 ●●●●●●●●●
196.3-220.5              10 ●●●●●●●●●●
* If the dose is more than 6 dots, divide the dose between both sides of the mouth
The first dose can be administered:
Approximately 30 to 60 minutes before the fear and/or anxiety eliciting noise stimulus
Or immediately after the dog shows first signs of anxiety or fear related to noise
Or when the owner detects a typical noise stimulus (e.g., fireworks) eliciting anxiety or fear in the dog
If noise lasts greater than 2–3 hours and the dog’s signs of fear and/or anxiety reappear, another dose may be given:
At minimum intervals of 2 hours between doses
Up to five doses can be given during one noise event

Main Ingredients

Dexmedetomidine Oromucosal 0.09 mg/ml, 3 ml syringe

SILEO is an effective and sound way to help dogs suffering from noise aversion. Read all about it by clicking SILEO

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Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe

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