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Bravecto Plus Topical Solution for Cats Rx

By Bravecto
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Bravecto Plus Topical Solution for Cats Description
Bravecto Plus Topical Solution for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment of infections with intestinal roundworm (Toxocara cati; 4th stage larvae, immature adults and adults) and hookworm (Ancylostoma tubaeforme; 4th stage larvae, immature adults and adults). Bravecto Plus kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick) and Dermacentor variabilis (American dog tick)] for 2 months. It's also the first and only U.S. product with protection against the Asian longhorned tick for up to 12 weeks
What is Bravecto Plus Topical Solution for Cats?
Bravecto Plus (Fluralaner/Moxidectin) is a Topical Spot On Solution for cats indicated for the treatment and prevention of flea and tick infestations, as well as preventing against heartworms, and the treatment of roundworms and hookworms for up to 8 weeks.
Which animals/pets is Bravecto Plus Topical Solution for Cats for?
Cats and Kittens 6 months of age and older weighing 2.6 pounds or greater
Bravecto Plus Topical Solution for Cats uses
  • Bravecto Plus treats and prevents flea and tick infestations as well as preventing against heartworms, and the treatment of roundworms and hookworms.
  • Longer duration (2 months) means less stress on cat and owner.
  • Extended duration (2 months) can help increase compliance.
What does Bravecto Plus Topical Solution for Cats do?
Fluralaner is for systemic use and belongs to the class of isoxazoline-substituted benzamide derivatives. Fluralaner is an inhibitor of the arthropod nervous system. The mode of action of fluralaner is the antagonism of the ligand-gated chloride channels (gamma-aminobutyric acid (GABA)-receptor and glutamate-receptor). Moxidectin is for systemic use and is a semisynthetic derivative of nemadectin, belonging to the milbemycin group of macrocyclic lactones. It binds to gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels of the nerves and muscles of the parasite resulting in hyperpolarization, paralysis and death.
Bravecto Plus Topical Solution for Cats side effects
The most commonly reported adverse reactions from Bravecto Plus include : vomiting, hair loss, itching, diarrhea, lethargy, dry skin, elevated ALT, and hypersalivation.
Bravecto Plus Topical Solution for Cats ingredients
Fluralaner and Moxidectin
Bravecto Plus Topical Solution for Cats overdose: What to do?
In case of overdose contact your closest emergency animal hospital. You may also contact Merck Animal Health Pharmacovigilance: Companion Animal Technical Services, 800-224-5318.
What to know before using Bravecto Plus Topical Solution for Cats
WARNINGS: Not for human use. Keep this and all drugs out of the reach of children. Do not contact or allow children to contact the application site until 2 hours post application. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. Do not eat, drink or smoke while handling the product. Avoid contact with skin and eyes. If contact with eyes occurs, then flush eyes slowly and gently with water. If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing, then seek medical advice immediately. Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. If the product accidentally contacts skin and a sticky residue persists after washing, rubbing alcohol (70% isopropyl alcohol) can be applied to the area to remove the residue. The product is highly flammable. Keep away from heat, sparks, open flame or other sources of ignition. Precautions: For topical use only. Avoid oral ingestion (see Animal Safety). Fluralaner, one of the ingredients in Bravecto Plus, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Use with caution in cats with a history of neurologic disorders. Use with caution in cats that are heartworm positive (see Animal Safety). Bravecto Plus has not been shown to be effective in kittens less than 6 months of age. The safety of Bravecto Plus has not been established in breeding, pregnant, and lactating cats. The effectiveness of Bravecto Plus to prevent heartworm disease after bathing or water immersion has not been evaluated
How is Bravecto Plus Topical Solution for Cats sold?
Sold in 2-month dose based on your cat’s weight:
  • Green: 2.6-6.2 lbs (Fluralaner 112.5 mg and Moxidectin 5.6 mg)
  • Blue: 6.2-13.8 lbs (Fluralaner 250 mg and Moxidectin 12.5 mg)
  • Purple: 13.8-27.5 lbs (Fluralaner 500 mg and Moxidectin 25 mg)
Bravecto is also available in the following:
Manufacturer
Merck
Overview
Dosage and Administration:
Bravecto Plus should be administered topically as a single dose every 2 months according to the dosage schedule below to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. 

For prevention of heartworm disease, Bravecto Plus should be administered at 2-month intervals. Bravecto Plus may be administered year-round without interruption or at a minimum should be administered at 2-month intervals beginning at the cat’s first seasonal exposure to mosquitoes and continuing until the cat’s last seasonal exposure to mosquitoes. If a 
dose is missed and a 2-month interval between doses is exceeded, administer Bravecto Plus immediately and resume the dosing every 2 months. 

When replacing a monthly heartworm preventative product, the first dose of Bravecto Plus should be given within one  month of the last dose of the former medication. 

Dosing Schedule:
Body Weight Ranges (lb) / Fluralaner content (mg/tube) / Moxidectin content (mg/tube) / Tubes Administered
2.6-6.2                              /             112.5                          /                5.6                             /            One
>6.2-13.8                          /              250                           /               12.5                            /            One
>13.8-27.5*                      /             500                            /                 25                             /            One 
*Cats over 27.5 lb should be administered the appropriate combination of tubes. 

A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use. 

Step 1:
Immediately before use, open the pouch and remove the tube. Put on gloves. Hold the tube at the crimped end with the cap in an upright position (tip up). The cap should be rotated clockwise or counter clockwise one full turn. The cap is designed to stay on the tube for dosing and should not be removed. The tube is open and ready for application when a breaking of the seal is felt. 

Step 2:
The cat should be standing or lying with its back horizontal during application. Part the fur at the administration site. Place the tube tip vertically against the skin at the base of the skull of the cat. 

Step 3:
Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. Avoid applying an excessive amount of solution that could cause some of the solution to run and drip off of the cat. If a second spot is needed to avoid run off, then apply the second spot slightly behind the first spot. 

Greasy, oily, or wet appearance may occur at the application site in some cats.
Main Ingredients
Active Ingredients : Fluralaner and Moxidectin

2.6-6.2 lbs Green (Fluralaner 112.5 mg and Moxidectin 5.6 mg)
6.2-13.8 lbs Blue (Fluralaner 250 mg and Moxidectin 12.5 mg)
13.8-27.5 lbs Purple (Fluralaner 500 mg and Moxidectin 25 mg)