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Item No.
52192
Cardalis Chewable Tablets for Dogs Rx
Strength:
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Cardalis Chewable Tablets for Dogs Description
Cardalis (Spironolactone and Benazepril Hydrochloride) is indicated with concurrent therapy (e.g. furosemide, etc.) for the management of clinical signs of mild, moderate, or severe congestive heart failure in dogs due to atrioventricular valvular insuficiency (AVVI). Cardalis is the only FDA approved combination drug for the management of congestive heart failure in dogs. Cardalis for dogs contains two active ingredients, spironolactone and benazepril hydrochloride, in a fixed ratio of 8:1 respectively.
Which animals/pets is Cardalis Chewable Tablets for Dogs for?
Dogs
Cardalis Chewable Tablets for Dogs uses
Only FDA approved combination drug for the management of congestive heart failure in dogs. Easy to administer chewable tablets. Available in various strengths.
What does Cardalis Chewable Tablets for Dogs do?
Mechanism of Action: The main pharmacological target of spironolactone and benazepril is the renin-angiotensin-aldosterone system (RAAS) at different levels in the cascade. Spironolactone and its active metabolites (including 7--thiomethyl-spironolactone and canrenone) act as specific antagonists of aldosterone (regardless of the source) by binding competitively to mineralocorticoid receptors located in the kidneys, heart and blood vessels. Benazepril hydrochloride is a prodrug hydrolyzed in vivo into its active metabolite, benazeprilat. Benazeprilat is a highly potent and selective inhibitor of angiotensin-converting enzyme (ACE), thus preventing the conversion of inactive angiotensin I to active angiotensin II. This prevents deleterious effects of vasoconstriction and aldosterone release, including sodium and water retention, and vascular and myocardial remodeling. However, aldosterone release is not fully controlled by ACE inhibitors because angiotensin II is also produced by non-ACE pathways. Therefore, concomitant use of the aldosterone antagonist spironolactone and the ACE inhibitor benazepril hydrochloride inhibits both ACE and non-ACE pathways.
Cardalis Chewable Tablets for Dogs side effects
The following adverse events were seen in fewer than 5% of the study animals, in decreasing order: urine abnormalities, uid in abdomen, ataxia, weight loss, digestive tract disorder, hypertension, electrolyte disorder, bronchitis, and hyperactivity. Renal insuficiency was reported more frequently in dogs treated with CARDALIS. This finding may be also attributed to the concurrent administration of furosemide. The incidence of death, including euthanasia and sudden death, was similar in dogs treated with CARDALIS or benazepril hydrochloride. In most cases, death was attributable to the progression of heart disease or the clinical signs associated with congestive heart failure. Deaths of unknown cause were presumed to be cardiac in nature.
Cardalis Chewable Tablets for Dogs ingredients
Spironolactone and Benazepril Hydrochloride.
Cardalis Chewable Tablets for Dogs overdose: What to do?
Contact your nearest emergency animal hospital.
What to know before using Cardalis Chewable Tablets for Dogs
Keep away from children and animals. Contraindications : Do not administer CARDALIS in conjunction with non-steroidal anti-inflammatory drugs (NSAIDs) in dogs with renal insuficiency. Do not administer CARDALIS to dogs with hypoadrenocorticism (Addisons Disease), hyperkalemia, or hyponatremia. Do not administer CARDALIS to animals with known hypersensitivity to ACE inhibitors or spironolactone.
How is Cardalis Chewable Tablets for Dogs sold?
Sold in bottles of 30 chewable tablets in the following strengths : 20 mg / 2.5 mg, 40 mg / 5 mg or 80 mg / 10 mg.
Manufacturer
Ceva
Overview
Use as directed by your Veterinarian.
Cardalis administration should begin after pulmonary edema is stabilized. Cardalis should be administered orally oncedaily at a dose of 0.9 mg/lb (2 mg/kg) spironolactone and 0.11 mg/lb (0.25 mg/kg) benazepril hydrochloride, according to dog body weight using asuitable combination of whole and/or half tablets. All tablet strengths are scored and the calculated dosage according to dogs weight should be to thenearest half-tablet increment. Cardalis should be administered with food.
Main Ingredients
Spironolactone and Benazepril Hydrochloride.