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Douxo S3 PYO Antiseptic Antifungal Shampoo for Dogs and Cats

By Douxo
(92 reviews)
Veterinary Diet Item
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Douxo S3 PYO Antiseptic Antifungal Shampoo for Dogs and Cats

By Douxo
$46.19
One-time purchase
$27.71 AutoShip & Save up to 40%
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Size: 16.9 oz
Size: 16.9 oz
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Product Overview

Douxo S3 PYO Antiseptic Antifungal Shampoo for Dogs and Cats (formerly Douxo Chlorhexidine Shampoo) is a medicated treatment for skin infections that are bacterial or yeast in cats or dogs. It can be used in a typical bathing routine to provide symptom relief for both dogs and cats.
Douxo S3 PYO Antiseptic Antifungal Shampoo is a medicated shampoo for cats and dogs with 3% chlorhexidine. This antiseptic shampoo penetrates deep into the skin to clear up bacterial and Malessezia (yeast) skin infections.
Douxo S3 PYO Antiseptic Antifungal Shampoo is intended for use in cats and dogs only.
  • Contains strong antiseptic properties in a shampoo meant to cleanse
  • Works through yeast and bacteria elimination
Made with an antiseptic solution, Douxo S3 PYO Antiseptic Antifungal Shampoo is made to contain phytosphingosine salicyloyl (0.05%) and chlorhexidine, chlorhexidine (3%) and lipacide c8g (2.5%). It has significant antiseptic properties.

It contains a modified pro-ceramide called phytosphingosine salicyloyl. It has antiseborrheic properties that aid in the controlling of cutaneous disorders related to pyoderma.

This lipo-amino-acid activity is similar to that of chlorhexidine. Additionally, Lipacide provides moisturize and restructures through the development of a lipo-protein film depositing onto skin. The film lasts a long time and is resistant to water which works by protecting skin from moisture loss and irritation.
No known side effects
Chlorhexidine Digluconate 3%, Ophytrium 0.5%
Contact your closest pet hospital.
Keep this medication away from your eyes and away from children.
6.7 oz and 16.9 oz bottles
Ceva
Douxo Chlorhexidine PS Shampoo should be applied as follows:
  • Using warm water, wet the fur
  • Apply the medicated shampoo to fur until a lather forms
  • Let product sit on fur for 5 to 10 minutes
  • Rinse well with clean warm water
Intended for use in managing severe or superficial conditions of the skin that respond positively to chlorhexidine.
Directions: Use one pump for every 4 lbs. Double the dosage for long and/or thick fur. Wet with cool water from the neck down. First, gently massage shampoo onto the problem area. Repeat on entire body and leave on for 5-10 mins before rinsing. Repeat if necesary. Wash hands after use.   
Active Ingredients : Chlorhexidine Digluconate 3%, Ophytrium 0.5%

About This Product

Customer Reviews

4.9
92 reviews
5 85
4 7
3 0
2 0
1 0
Gail B Verified Purchase
October 20, 2026

The vet says you can use this product every week and it will not dry out your dogs skin. So far so good.

Paul K Verified Purchase
April 20, 2023

This product is a lifesaver if you have a pet with certain types of skin problems. You definitely have to use it a couple times a week when you start but after that I was able to cut back to every 10-14 days.

Sylvia H Verified Purchase
July 17, 2022

Works well on my dogs sensitive skin

Carol K Verified Purchase
November 3, 2021

Shampoo really works.

Guadalupe G Verified Purchase
November 3, 2021

it turned out to be a good product for my dogs skin allergy

Carmen B Verified Purchase
September 23, 2021

I bought Douxo S3 PUP Antiseptic Antifungal Shampoo because it was highly recommended by a professional I trust.

Lisamarie R Verified Purchase
July 12, 2021

It’s a great shampoo for dogs with allergies

Ricardo F Verified Purchase
June 22, 2021

Awesome

Rosetta G Verified Purchase
June 22, 2021

Just purchase my first bottle will let you know

Tanya W Verified Purchase
May 3, 2021

I have been using this for years on my toy schnauzer! She would get dandruff really bad when I first got her but since he’s in there it’s almost gone away completely

Rita R Verified Purchase
May 3, 2021

My Bichon dog has very bad allergies. These is the only shampoo that helps my dog. Plus the doctor told to try this shampoo.

Shelly A Verified Purchase
October 29, 2020

We have a boxer with environmental and food allergies. This shampoo fights bacteria and yeast, which helps to limit how often he gets a skin infection. It works like a charm! Allivet has the best price and the most wonderful customer service!

Linda N Verified Purchase
October 13, 2020

great product for fungus control. Odorless, low suds & leaves coat shinny and soft1

Dorcas K Verified Purchase
October 12, 2020

Highly recommended for sensitive skin. It is soothing and non drying. Dermatologist from UC Davis recommended this product for my baby and I've been using it for years with great results.

Lori B Verified Purchase
August 11, 2020

Works great on my English Bulldog

Aline N Verified Purchase
August 10, 2020

My 100 lb St Bernard/husky experiences summertime itchy spots. This product helps ward it off

Sara S Verified Purchase
July 31, 2020

This shampoo helps control my dog’s atopic dermatitis condition.

Thomas R Verified Purchase
July 8, 2020

Has worked better than the other shampoos we have used for skin issues on our Yorkie

Janet C Verified Purchase
June 2, 2020

Stops the flank sucking and paw chewing in one bath. Repeating once a week keeps her itch free.

Susan D Verified Purchase
May 26, 2020

Is the cheaper than Vets. The results are fine

Jennifer o Verified Purchase
May 5, 2020

Vet recommended

Julie W Verified Purchase
April 13, 2020

This shampoo is a miracle for yeast issues. I won’t use anything else.

Sylvia M Verified Purchase
April 7, 2020

awesome stuff for my fur babies Shar Peis coat really improved with this product

Cecilia R Verified Purchase
April 7, 2020

It relived some of the itching on my two dogs, they now sleep threw the night.

Ellsworth W Verified Purchase
March 3, 2020

work great on our yorkie

Angie S Verified Purchase
March 3, 2020

Excellent shampoo for my little pooch!

Peter T Verified Purchase
February 6, 2020

My Vet recommended it.

Christina R Verified Purchase
February 6, 2020

Very affordable and does its job!

Julie W Verified Purchase
December 10, 2019

This shampoo is great for yeast. It also leaves the hair silky soft.

Deirdre L Verified Purchase
December 4, 2019

This is the only shampoo that helps with my dogs skin issues due to allergies.

JILL H Verified Purchase
November 12, 2019

The vet charges the same price for a bottle half this size! SOLD! The price is right and it helps calm down my 10 year old cocker spaniel's allergy-itchy skin.

Peter D Verified Purchase
November 6, 2019

Our regulat source discontinued this item so purchased from Allivet, works vey well for our dogs skin allergy issues.

Aida L Verified Purchase
October 25, 2019

Love this Shampoo it help my dogs with the allergy skin. They are very clean.

Sandra W Verified Purchase
October 18, 2019

Vet recommended

Brittnay C Verified Purchase
July 8, 2019

Was so damn awesome

Arturo D Verified Purchase
May 29, 2019

Very much cheaper than my Vet

Ralph L Verified Purchase
April 22, 2019

Allivet isn't a very good on line distribution with great products for my dog

Caitlyn R Verified Purchase
March 15, 2019

Vet recommended Chlorhexidine for my french bulldogs skin allergies. Her skin will flair up with bumps and she is losing hair on her back legs.

Robert B Verified Purchase
March 5, 2019

This stuff works on my Welshie!

Diana Y Verified Purchase
January 11, 2019

Great product! Leave hair soft and helps with the dry skin and itching.

Suzanne O Verified Purchase
December 26, 2018

Great Products Good Prices Sue

Barbara W Verified Purchase
November 19, 2018

Fabulous Shampoo for dogs with Allergies. Really can see a significant difference for the better!

Terri B Verified Purchase
October 2, 2018

Less money than other sites.

David U Verified Purchase
October 1, 2018

Best price on the internet for this top-notch product!

Bridgette S Verified Purchase
August 7, 2018

I have 4 dogs that are constantly itching from environmental exposures. This shampoo has definitely helped with itch factor and general redness of affected areas.

Doug M Verified Purchase
July 17, 2018

We have a beautiful red female Doberman with an ongoing skin condition. she has been to the vet many times with no results. the breeder suggested Douxo shampoo ,so we tried it and results were almost immediate! This stuff works, we couldn't be happier with the results.

Scott K Verified Purchase
April 30, 2018

this shampoo is excellent for skin and coat problems. It cleared up our 13yr old shihtzu in 3 weeks with weekly washing.

Lonnie B Verified Purchase
April 23, 2018

works awesome on my dog with malassazia yeast infection.

LaMonte S Verified Purchase
January 10, 2018

Best dang shampoo for any dog with allergies in my book.....My GSD is allergic to human dander and ant detritus. Essentially, he is constantly under attack, especially during the summer months. This shampoo is a godsend for his scratching and flakiness. Awesome!

Susan M Verified Purchase
November 10, 2017

Price is fabu

KAREN L Verified Purchase
September 25, 2017

I am very satisfied with the product and pleased with the price and amount of time for delivery.

Wendy M Verified Purchase
September 13, 2017

This is the best shampoo for 2 of my cats. They have itchy skin and this helps them a lot.

Ellen B Verified Purchase
September 13, 2017

This product makes a difference for a couple of days. In combination with the dermoscent and a healthy diet with omega essentials, my dog doesn't itch!

Deborah M Verified Purchase
September 3, 2017

Our dog has problems with seasonal allergies. The vet recommended that we use this shampoo twice a week to help treat the "hot spots" that had developed. It worked great!

Joshua D Verified Purchase
August 21, 2017

This is the same product I get at my vet for my pet's skin and the bottle is HUGE compared to what I get at my vet and it cost less!

Sharon M Verified Purchase
August 21, 2017

Bought this because her surgery is making her body do weird things (thyroid and cholesterol) and now dry patches. Her ER doctor suggested this shampoo.

Kolleen K Verified Purchase
August 14, 2017

Allivet allows me to be able to afford the medicated shampoo my pet needs vs. the excessive vet cost.

Yvonne G Verified Purchase
August 3, 2017

Great shampoo. The only one that actually worked on my Maltese who had itching for so long. The best.

Tricia T Verified Purchase
July 10, 2017

My daschund is 14 years old. I was leary at first because of her age, but she responded to this product well and it cleared the fungus up quickly!

Diane M Verified Purchase
April 13, 2017

Has already helped calm my dogs skin irritations

Jeremy M Verified Purchase
March 14, 2017

Our dog needs help and this stuff works

Evelyn E Verified Purchase
January 7, 2017

Best shampoo ever for skin mites. You would see improvement in coat in just a few days.

Ariel D Verified Purchase
December 15, 2016

This is a good product. The bottle was much larger than I thought it would be. It reduced the redness almost immediately and smells great.

Darlene W Verified Purchase
November 11, 2016

Saved $10.00 dollars by ordering my dog's shampoo through Allivet ..

Donna H Verified Purchase
August 24, 2016

awesome product, awesome price, and awesome company! That says it all!

Amy H Verified Purchase
August 14, 2016

Used this shampoo on two dogs that had really bad skin issues and it works great.

Erica R Verified Purchase
July 14, 2016

Really helps relieve skin allergies.

Dusty A Verified Purchase
July 13, 2016

This works miracles on my dogs skin. She has been losing hair due to allergies and this has helped restore it.

Dusty A Verified Purchase
July 13, 2016

This works miracles on my dogs skin. She has been losing hair due to allergies and this has helped restore it.

Mary S Verified Purchase
July 7, 2016

The prices are excellent, and the entire purchasing and check out process was so easy. My order shipped that day and I got it within a couople days. I will bw shopping there again!

Marianne B Verified Purchase
July 2, 2016

Fast and quick!

Rosemary B Verified Purchase
June 23, 2016

This shampoo was recommended by my Vet, and I have found it very helpful in treating the 'Santa Barbara Itch' which happens every summer into late fall, in Santa Barbara Ca. Due somewhat to heat, humidity and allergies.

Catherine H Verified Purchase
June 16, 2016

Works to calm my collies super sensitive skin.

Laura G Verified Purchase
May 31, 2016

Both of my Akita's have skin issues and it lathers up real good and makes them smelling great!

Nancy H Verified Purchase
May 27, 2016

The Douxo Chlorhexidine shampoo in known as the magic shampoo in our house. At the first sign of a skin outbreak i lather it on the affected area and leave it for ten minutes. Rinse and pat dry. It's clears the area quickly.

Carol S Verified Purchase
May 19, 2016

I have tried several antibacterial shampoos and this one seems to work the best. Also smells good compared to the other ones. Awesome price too!

Raymond S Verified Purchase
April 16, 2016

both suggested by my vet and they work great.

Brenda m Verified Purchase
April 6, 2016

for the health of my dogs

Nancy O Verified Purchase
March 21, 2016

My dog's dermatologist recommended this shampoo as my dog had yeast on his paws. This is a wonderful shampoo. It doesn't strip all of the dog's natural oils out of the skin. I have to bathe my dog once a week which I was reluctant to do because it's really not good to shampoo a lab too often. With this product no worries though. The dermatologist also recommended HyLyt creme rinse to be used with this product. Great combo. Allivet has the best prices and I received my order in just a few days!

Susan B Verified Purchase
January 28, 2016

Have tried many others and Douxo is the best! Also has no lasting scent!

Rebecca F Verified Purchase
December 17, 2015

Have used this for a few months on vet's advice. Paid in the $30.00 range at the vet's office. Needless to say, this shampoo is getting the job done and at a much less cost. Just for the record, the shampoo was not sealed too well and it leaked out into the shipping box. But I am pleased with this product because nothing else was keeping the sores off my furbaby.

Arnold v Verified Purchase
December 14, 2015

This product has cleared up a skin condition my pet has had for several years. We had given up that it would ever improve.With just 2 shampoos there was dramatic results and improvement.

Susan A Verified Purchase
December 3, 2015

My West Highland Terrier is having allergy problems and a lot of other Westie owners suggested this.

Francine D Verified Purchase
November 10, 2015

It was determined that our golden retriever dog was had an allergy that developed into a staff infection. We purchased this product from our vet at a much higher price. Allivet offered the best price and delivery was outstanding! This product is offering relief and we are administering it according as prescribed. Thanks Allivet!!!

Karen L Verified Purchase
November 3, 2015

Our dog has a skin condition and has to shower once a week. I had been using another product that was hard to find so in research I was able to use this product and have same/better results. I also liked that I could purchase in a larger size. This way I only have to refill a smaller bottle. I will be returning when I get through the first and will be finding out if other products he uses are available here too.

Amina t Verified Purchase
October 22, 2015

great product

Deborah D Verified Purchase
October 20, 2015

This is a great product for helping control yeast and fungal infections or preventing them in irritated areas. My dog has sensitive skin, and allergies. This product helps prevent yeast infections below his eyes from tearing. Alleviate sent this product promptly, and I am very happy with it.

Jill R Verified Purchase
October 14, 2015

Prescribed by my veterinary dermatologist for canine adopt and yeast infection and just weekly maintainence. Smells great, makes the coat super shiny and seems to make her itch less.

Yana V Verified Purchase
October 6, 2015

healing infection nicely

Sharon W Verified Purchase
September 30, 2015

This is a pricey but Excellent shampoo for my dog that suffers from yeast infections in hot humid weather. This is the only thing that completely eliminates the foul odor and itchy red skin.

Victoria h Verified Purchase
July 15, 2015

vet recommended shampoo, will let you know if it helps Junior

Jeremy M Verified Purchase
June 1, 2015

Our dog is a wolf and he has a skin problem and our vet has us using this and after his hair fell out this repaired him and he has grown all his hair back but we must keep giving his baths because it keeps coming back we also use a half vinegar half water in his ears to keep it out of his ears.

Questions & Answers