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GenOne Topical Spray (Gentamicin/Betamethasone)

(95 reviews)
Veterinary Diet Item
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GenOne Topical Spray (Gentamicin/Betamethasone)

$7.92
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Product Overview

GenOne Topical Spray (Gentamicin/Betamethasone) treats infected superficial wounds caused by gentamicin-susceptible bacteria. It is a comprehensive antibiotic that is incredibly effective in topically treating bacterial skin infections.
For use in dogs.
Features of GenOne Topical Spray:
  • Offers anti-inflammatory and antibacterial action for infected and irritated skin lesions
  • Controls itch
  • Effectively treats hot spots
  • Aids in the treatment of bacterial skin infections
Gentamicin is a broad-spectrum aminoglycoside antibiotic. It is an incredibly useful topical treatment for gram-negative and gram-positive bacterial skin infections. Betamethasone valerate offers antipruritic and anti-inflammatory activity for topically managing corticosteroid-responsive infected superficial skin lesions.
Potential adverse reactions include:
  • Cushing's syndrome (in dogs with repeated or prolonged steroid therapy)
  • Diarrhea (occasionally bloody)
  • Vomiting
  • Polyuria
  • Polydipsia
  • Anorexia
  • Weight loss
  • SGPT enzyme elevations
  • SAP enzyme elevations
Each mL contains: gentamicin sulfate equivalent to 0.57 mg gentamicin base, betamethasone valerate equivalent to 0.284 mg betamethasone.
Contact your closest emergency pet hospital.
  • Keep out of reach of animals and children.
  • Do not ingest.
  • Do not administer beyond the 7-day recommendation. This can lead to delayed healing of wounds. Closely monitor any animal treated beyond 7 days.
  • If hypersensitivity occurs, withdraw treatment and seek veterinary attention.
This product should not be used in pregnant animals. It can lead to:
  • Anasarca
  • Phocomelia
  • Foreleg deformities
  • Other congenital anomalies
  • Cleft palate
  • Metritis
  • Retained placenta
  • Fetal death
  • Dystocia
  • Premature parturition
60 ml, 120 ml or 240 ml spray bottles
VetOne
Prior to treatment, remove excessive hair and clean the lesion and adjacent area. Hold bottle upright 3 to 6 inches from the lesion and depress the sprayer head twice. Administer 2 to 4 times daily for 7 days.
Each depression of the sprayer head delivers 0.7 mL of GenOne Topical Spray.
Each mL contains: gentamicin sulfate equivalent to 0.57 mg gentamicin base, betamethasone valerate equivalent to 0.284 mg betamethasone.

About This Product

Customer Reviews

4.9
95 reviews
5 89
4 6
3 0
2 0
1 0
Customer review photo
Customer review photo
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Kathy J Verified Purchase
October 16, 2026

MIRACLE MEDICATION FOR HOT SPOTS

MY POOR LITTLE CORGI "JAX" WOULD NOT SURVIVE THESE HOT, HUMID DAYS IN LOUISIANA WITHOUT THIS SPRAY FOR HIS "HOT SPOTS"...I ALWAYS HAVE IT IN MY CABINET FOR HIM!!!

PAM T Verified Purchase
August 7, 2026

great medication

Dennis M Verified Purchase
July 28, 2026

GenOne Topical Spray is amazing!

My Diesel, at 14 years old, developed a weird skin infection. It looked horrible at first, but after the vet prescribed GenOne (a small bottle) I saw how effective it was. Now this didn't happen overnight or even over a few days. It did take about two weeks for the dark patch to turn to pink healthy skin (and the vet encouraged gently scratching off the scabs as it was itchy for Diesel - i was stunned). In any event, I did order a few refills of the spray from Allivet, and in about two months of use, Diesel's fur completely grew back as you can see in the photos. Stuff is amazing, but you have to be consistent with its use.

Nancy S Verified Purchase
November 4, 2024

GenOne spray is great. I use this spray on my dogs allergy sensitive feet and if my dogs get a scratch running through the brush I wash the scratch with soap and water then a little Genone spray on the scratch for a few days

Cheri A Verified Purchase
August 30, 2024

My pooch has allergies that result in seriously inflamed feet. This medication works for him. Also the price is good.

Eden C Verified Purchase
August 21, 2024

The reason I bought this is because it works. I’ve used it before, and it really helps my dog with irritation on his belly.

Cindy K
June 15, 2024

We have been using this on our golden retriever for several years. The vet prescribed it once and we havent stopped using it ever since. Maverick gets inflamed rashes in his groin, chest, front legs and occasionally on his back too. Some turn into hot spots. We do not want to put him on expensive steroids that have major side effects. Weekly baths, this spray and medicated foot powder keeps it at bay. He suffers from outdoor allergies and this really helps the most. If we travel we always bring a bottle with us!

Karel S Verified Purchase
April 26, 2024

Been using this spray on my dogs for years. Great for stopping allergy inflammation.

Cheri A Verified Purchase
April 11, 2024

This is being used to treat my dog's yeast infection. Works great but must be applied every day or every other day for consistent treatment.

LISA B Verified Purchase
March 12, 2024

This product was highly recommended by my dog groomer and I bought my first 2 oz from my vet and it works great. I wanted to see if I could get it online for a little less than what the vet charges, so I bought the 4 oz and then I will have plenty for back up. My Weimaraner had some issues with hot spots around the neck area. Now that I have been using this for a few weeks his redness has diminished a great deal and his hair is growing back in those areas!

Juan H Verified Purchase
November 23, 2023

When my dog ate something and got an allergic reaction to her skin the vet prescribed me GenOne Topical Spray helped her in her rash and on the itching

Karlonda A Verified Purchase
August 30, 2023

We use this spray to helps with my dogs skin infections that won’t seem to go away!

Svetlana G Verified Purchase
November 30, 2022

After first use the redness on skin almost gone and skin appeared much healthier

Alex
November 16, 2022

Great product for a good price. Works well to treat irritated skin on our dog.

Brenda K Verified Purchase
June 30, 2022

they have what my pups need and always priced right

Itsel O Verified Purchase
February 16, 2022

Having a highly allergic dog it can get very pricy to keep his medications in stock. I can get them here for a third of the price at the vets office and mailed to my home. I love this spray but it’s hard not to run out soon.

Courtney S Verified Purchase
November 3, 2021

This stuff helps with my pyrs skin issues! It helps with inflammation and kills bacteria. This is a everyday spray for my pyrs!

Cindy H Verified Purchase
September 1, 2021

Great product. Works!!

AL V Verified Purchase
August 18, 2021

Works good

Linda R Verified Purchase
August 18, 2021

great product

WILLIAM G Verified Purchase
June 28, 2021

Great Product

Don w Verified Purchase
May 3, 2021

after years of searching, a product that relieves and eliminates the nasty rash our dog has had

Suzanne S Verified Purchase
May 3, 2021

Your web site is annoying- you will not accept the security code- a lot of Hassell

Kay S Verified Purchase
May 3, 2021

This spray works wonders!!! I love it!!

Teresa T Verified Purchase
May 3, 2021

The best stuff for my shih tzu’s skin condition; clears up quickly with use. However since Huey is on Apoquel, gotta be extra careful about the frequency of its use. Consult with your vet!

Marie S Verified Purchase
April 26, 2021

Good product

Forrest W Verified Purchase
April 26, 2021

Super great product

Edwin s Verified Purchase
March 23, 2021

my dog has a lot of allergies and hot spots. shave hotspots an spray goes away, helps with other minor skin problems an itching that gos with that. twice the size same price as vet .

Vickie R Verified Purchase
January 13, 2021

Saved 20 dollars!

Sonia R Verified Purchase
December 8, 2020

Doctors Recommendation

Taylor B Verified Purchase
December 8, 2020

My white Pitty gets rashes on her belly. This medication clears the area!! Its awesome!

Tammy R Verified Purchase
November 24, 2020

Helps stop the itchy pup from seasonal allergies

Lisa D Verified Purchase
August 11, 2020

For itching and hot spots

JEROME M Verified Purchase
July 14, 2020

WORKS GREAT ON MY DOGS ITCHY FEET

Regina C Verified Purchase
May 22, 2020

Very Good Price On This Item!

Vinya C Verified Purchase
May 5, 2020

Work really well! I have a Yorkie who has bad skin allergies, this always heals his skin after one spray!

Valerie A Verified Purchase
May 5, 2020

Great price Quality product

Maureen M Verified Purchase
April 7, 2020

Very helpful and easy

Jennifer A Verified Purchase
April 7, 2020

Great product

NIGEL W Verified Purchase
February 10, 2020

Our German shepherd is very prone to hot spots and they can be difficult to heal, but this product totally takes care of the problem and lets the healing begin.

Brenda J Verified Purchase
November 21, 2019

I highly recommend this product for anything from hives to stubborn sores.

Michelle T Verified Purchase
October 25, 2019

Excellent prices and so convenient!

April F Verified Purchase
August 23, 2019

Great for hot spots

Lynette D Verified Purchase
July 31, 2019

For 2 years my Doxie has suffered from itching& scratching. Tried all kinds of sprays..nothing worked. Then a friend said to try GenOne. OMG...amazing stuff! Sadie is now leading a life without scratching. I still can't believe how peaceful she is now. TEN stars

Nicole N Verified Purchase
July 8, 2019

AMAZING, wish they sold it by the gallon!

Rajesh S Verified Purchase
July 2, 2019

This works great on most rashes. My dog gets contact dermititis from time due to doggie day play place he goes to. This really helps him in just one application. He is clear in just 3-4 applications. Highly recommend.

Shannon S Verified Purchase
June 19, 2019

Really effective for pyoderma patches due to allergies.

Julie d Verified Purchase
May 29, 2019

Our 4 year old Pyrenees gets terrible skin rashes in the hot summer months and the GenOne spray is the only thing that seems to control it. Thank goodness for some relief for our poor girl!

Valerie B Verified Purchase
April 29, 2019

best product it works great on my 15 year old shitzu

Lalitha P Verified Purchase
April 29, 2019

A must have for minor cuts, abrasions, nicks or irritation. Works well and 1/3 of the cost charged by the vets office for the exact same thing.

Carlos k Verified Purchase
March 27, 2019

Works great fast delivery

Rajesh S Verified Purchase
March 18, 2019

Helps my golden with itchy skin and rashes.

Dana R Verified Purchase
January 7, 2019

My pitty has Pemphigus, this helps his sores.

JEROME M Verified Purchase
October 19, 2018

EXCELLENT SERVICE AVAILABILTY OF PRODUCT & SHIPPING.!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Rajesh S Verified Purchase
October 2, 2018

Helps heal contact dermatitis on my golden retriever within days. You will see the difference on first application.

Julie d Verified Purchase
July 10, 2018

Our Great Pyrenees/Turkish Akbash has ultra sensitive skin and she gets terrible rashes in the summer which require oral antibiotics if the rashes get out of control. In order to try and avoid that, we use this topical spray and it really helps. I highly recommend Gen One.

Jan R Verified Purchase
June 14, 2018

Miracle product for topical wounds and hot spots cats or dogs. Would not live with pet without Genone in the emergency cabinet

Barbara M Verified Purchase
May 14, 2018

Works great on itchy paws!!!

Selvin j Verified Purchase
April 30, 2018

very effective on the rashes that my dog gets periodocaly

Richard C Verified Purchase
April 23, 2018

This is the best on minor wounds such as hock sores.

Sheila G Verified Purchase
April 4, 2018

Stella sucks on her inner thigh, this medicine works really well for the allergy, clears it up.

Andrea C Verified Purchase
March 23, 2018

My doggies love those greenies!

MerleMICKAS G Verified Purchase
January 12, 2018

my dog is pleased with the product and service.

Suzanne A Verified Purchase
December 26, 2017

My dog stopped itching and the open hot spot healed quickly after I started the spray.

Kathy S Verified Purchase
December 1, 2017

Help with hot spots on her skin.

Ashley O Verified Purchase
October 19, 2017

This stuff works great for our bulldog's warts between her toes. A week of 1 spray in the morning and 1 at night and they are gone!

Patricia W Verified Purchase
August 4, 2017

This product works great on my dog. Without this product my dog would be covered with a rash and itching all the time.

Deborah s Verified Purchase
August 3, 2017

really works!

Cindy J Verified Purchase
August 1, 2017

Works great for my dog's rash that she gets occasionally.

Mary S Verified Purchase
May 6, 2017

I bought GenOne Spray because my dog Emily has had skin and ear issues since she was a year old (poor gilr) - And my vet said she will have to use GenOne the rest of her life. She is 12 years old and it really helps her ears, and now I know it also helps with hot spots! I am so happy I found Allivet online, I am going to tell everyone I know how affordable Allivet is ~ I will definitely use Allivet again! Customer serivce was excellent as well ~ Thank you, Mary Shauger

Sylvia M Verified Purchase
April 13, 2017

Works great on Hot Spots

Michaela K Verified Purchase
January 11, 2017

Works very good.

Belkis P Verified Purchase
October 19, 2016

This really work for my dog!!

Anne S Verified Purchase
August 5, 2016

great

Vida V Verified Purchase
July 25, 2016

Great price!

Daniel M Verified Purchase
July 15, 2016

Even with shipping the item cost half as much for twice the amount.

Kathy A Verified Purchase
July 1, 2016

My boy got hot spots or whatever it was all over his body...little, scaly spots...about l4 or so all over. Went to 2 different vets who gave him oral meds (expensive oral meds-daily) and an antibiotic, and a shampoo....took meds for three months and when fall came...got the rash/spots anyways. My brother told me about GenOne (got from his vet)....been using ever since.

Paul H Verified Purchase
February 5, 2016

This stuff works miracles on any of my golden retriever's skin issues. I won't be without it (as long as my vet keeps adding to the prescription).

Lolita G Verified Purchase
January 14, 2016

I love this product, it is a prescriptive medicine for my Darby, I use it for his skin allergy or tick and it works with no side effects. Since then, I make sure I always have a spare one and good maintenance.

Susan B Verified Purchase
December 8, 2015

This product is amazing! Our dog has had major wounds on his back leg for over a year or more. We spent around $2000 trying the heal this leg and when we used this product, it cleared up within a week. Believe it!

Renee A Verified Purchase
September 23, 2015

This works perfectly for my bulldogs feet. Because of her allergies, she is constantly chewing at her feet which makes them more irritated. After a week of using this spray twice a day, all the red is gone and the hair has grown back. No more wet spots on the furniture!

Loni A Verified Purchase
September 1, 2015

This topical spray works great on my dogs and cats skin irritations. They both have allergies that result in skin irritations.

S L Verified Purchase
July 27, 2015

This is like a miracle spray for the animals with any sores.

Mary L Verified Purchase
July 20, 2015

Refill prescription from Vet who charged more than double for this medication.

Olga K Verified Purchase
July 6, 2015

Works well! Hot spot heal fast

Mark S Verified Purchase
June 27, 2015

This is the only product that seems to work on my boy Jesse James. He gets sores on his stomach and I just spray this on and he don't etch and that's all there is to it love this product Thank You for the good price Too.---------MS

Sharon h Verified Purchase
June 21, 2015

price was good

Nikki h Verified Purchase
May 25, 2015

Wonderful temporary relief on itchy 'spots'....

Teachermos Verified Purchase
May 13, 2015

We use GenOne spray on conjunction with Ketochlor shampoo to help my dog with a skin fungus she picked up in the yard. GenOne helps to spot-treat the condition, but we still have to treat the yard with an anti-fungal in order to control the problem.

Juanita P Verified Purchase
February 12, 2015

helps with my Boxers chronic yeast ear problems

Judith H Verified Purchase
January 4, 2015

All I can say is that it works when so many other things failed to stop my dog from licking and helping her skin to heal.

John Z Verified Purchase
August 19, 2014

My dog has allergies???! Cost is 1/3 the price

Resinto P Verified Purchase
June 27, 2014

Fair prices. Should leave coupons around for when they are needed longer for regular customers. Have always been able to reach someone if there's been an issue with an order, and they follow up right away. Would definitely recommend them.

Jessy t Verified Purchase
June 18, 2014

I have used Allivet for 7 years for filling my pets prescriptions. They have excellent name brand products, the same the vet sells you, at much more competitive pricing. I buy both prescription and OTC supplies for my 4-legged family. Great customer service, shipping, and product!! Great job on the GenOne Topical Spray its great.

Lee H Verified Purchase
May 31, 2014

My dog got into it with my neighbors dog, they never liked each other. It finally came to be last week when they bought for the first time and my dog got some cuts on he’s left leg. A friend of told me about GenOne Topical Spray after he’s dog got into a fight. I tried it and it worked I definitely recommended.

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