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PancrePlus Powder

By PancrePlus
(243 reviews)
Veterinary Diet Item
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PancrePlus Powder

By PancrePlus
$92.32
One-time purchase
$52.32 AutoShip & Save up to 50%
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Product Overview

PancrePlus Powder is a concentrated porcine pancreatic enzyme. It is a useful digestive aid for replacement therapy when digestion of fat, carbohydrates, and protein is inadequate because of exocrine pancreatic insufficiency.
PancrePlus Powder is a pancreatic enzyme to aid in the digestion of protein, carbohydrates, and fat due to a pancreatic insufficiency in dogs and cats.
For use in cats and dogs.
Features of PancrePlus:
  • Prevents malnutrition
  • Absorbs all the nutrients in all of your pet's meals
  • Reduces the symptoms of exocrine pancreatic insufficiency (EPI), improving your pet's quality of life
  • Helps your pet digest foods by producing the necessary pancreatic enzymes and fat soluble vitamins
PancrePlus Powder can be mixed with moistened dry or canned food. In order to bring the enzymes into contact with food particles, PancrePlus should be thoroughly mixed. The pancreatic enzyme concentrate contains protease, lipase, and amylase, which are three major enzymes. Fats are broken down by lipase; protein is broken down by protease; and carbohydrates are broken down by amylase. All of these breakdowns are crucial to proper nutrition.
Mucosal irritation could occur with use of PancrePlus.
Each teaspoon of Pancreplus powder contains lipase, protease, amylase.
In case of overdose, contact your closest emergency pet hospital.
If your pet exhibits sensitivity symptoms, discontinue use.
4 oz, 8 oz, and 12 oz bottles.
VetOne
  • Supplementing with fat-soluble oral vitamins is recommended and widely accepted. However, there is no official ideal dosage.
  • The serum concentrations in fat-soluble Vitamins A, D3, and E are usually substandard in cats and dogs with pancreatic insufficiency. Enzyme treatment alone may not resolve this.
  • Large dogs may require significantly more PancrePlus to achieve digestive health.
Dosage & Administrarion: Always use as directed by your veterinarian. Dose is administered before each meal. Estimate dose according to the severity of the condition and weight of the animal. PancrePlus Powder is added to moistened food (canned or dry). Thorough mixing is necessary to bring the enzymes into close contact with the food particles. After mixing, let stand at room temperature for 15-20 minutes.
Average dose/meal:
Dogs: 3/4 to 1 teaspoon (2.8 g/teaspoon)
Cats: 1/4 to 3/4 teaspoon
Each 2.8 grams (1 teaspoon) of PancrePlus Powder contains a minimum of:
Amylase 460,000 USP units
Protease 388,000 USP units+
Lipase 71,400 USP units

About This Product

Customer Reviews

4.9
243 reviews
5 231
4 12
3 0
2 0
1 0
Arthur H Verified Purchase
August 12, 2026

A needed medicine for our dog

This is a needed medication for our GSD who has a pancreatic shortcoming, and this is keeping him healthy.

Michael l Verified Purchase
October 21, 2025

New Texture or Process?

My GSD requires PancreaPlus as he has a pancreatic enzyme disfunction. I have been giving him this product for over 2 years. My Vet advised me there may be some variation in this product as to the process in which the hog pancreas is harvested, handled and processed. With one batch I did need to increase the recommended dose slightly to get the same results. This batch is exceptional. It seems finer, does not pack down in container and more potent. The results from this batch are the best ever.

Beverly R Verified Purchase
August 28, 2025

Saved a life!

PancreaPlus saved my furbaby's life....no doubt about it. She will be on it, for what I hope, is a very long life...

Ethan C Verified Purchase
December 18, 2023

My little girl Jasmine has had a stomach issue ever since I adopted her. She would always have the runs, I tried pumpkin and pumpkin powders. It got a little better than worse, she was loosing a lot of weight. The vet stated she did not have the enzymes to break down her food after many tests. I bought the powder prescribed by my veterinarian, and she has not had the runs since.

Olivia C Verified Purchase
October 30, 2023

My 6 yr old GSD has EPI. The PancrePlus Powder saved her life. Her pancreas is atrophite. The PancrePlus powder is a miracle powder.

Michelle R Verified Purchase
October 3, 2023

My German Shepherd has an enzyme deficiency syndrome so we add this to her food and it helps her to receive the nutritional value that she wouldn't otherwise get. It has worked great for her. We wet her food so it sticks and let it sit for 20 mins.. She doesn't mind it at all. We're very pleased with this product!

Juanita P Verified Purchase
April 4, 2023

Saved my baby!! My shiba was in the danger zone before he got on this medicated powder, started on a Monday night when he was brought home from the vet by Wednesday night his old self was starting to come back to us!! on week 4, he was back to his normal self.

Josh
December 15, 2022

My dog has been on this medicine from this company for 8 years. Never had an issue what so ever with the medicine or getting it immediately when was needed!

Christine R Verified Purchase
October 4, 2022

Not only does my dog need this med but Allivet has the best pricing! I have looked at many other pharmacies, but Allivet always comes up cheaper!

Michelle G Verified Purchase
March 1, 2022

My German Shepherd has EPI. This is the only thing that helps.

Kristine H Verified Purchase
January 18, 2022

This is the best price I have found for this life saving Pancreplus powder. Thank you! On the site I used to use, it was originally $137 and in two weeks jumped to $182 - Thank you Allivet for not gauging customers.

Kelly C Verified Purchase
January 17, 2022

PancrePlus powder saved my dogs life. If your dog was recently diagnosed with EPI, get this product immediately.

Billie J Verified Purchase
November 3, 2021

It works amazing

Dean B Verified Purchase
November 3, 2021

Previous supplier only has large size PancrePlus, dog is elderly and may not survive long enough to us large size. Having a 4oz quantity is more cost effective under these circumstances.

Kathleen E Verified Purchase
November 3, 2021

PancrePlus Powder saved my pets life. She was on other kinds of medicine for her pancreas, but this is the only one that worked for her. Allivet is the best pharmacy for price and service

Kurt H Verified Purchase
September 23, 2021

It's so easy and reliable, and the price is fair, I can't imagine why I would go somewhere else for our dog's health.

Bobbi G Verified Purchase
September 23, 2021

Veterinarian prescribed for dog with IBD and EPI.

Lucia F Verified Purchase
August 2, 2021

Pancrea powder saved my GSD’s life! He is still thriving at 12 years old!! Thank you Allivet for your great service to get this product out to us ASAP! My dog cannot eat food without this powder mixed with it! It was a relief to see the package arrive the next day as we were literally at the very end of our last bottle! Thank you!!

Diana S Verified Purchase
July 29, 2021

Powder is great l, ever since my cat starting using it she's gained weight and looks really health. Only issue I'm having is the price keeps going up. It's went up $40 since my last order. She needs the medicine but it's getting harder to afford.

Mary U Verified Purchase
July 8, 2021

Had to select a different product because the manufacture isn't making the original product that I have been using for 10+ years. I hope this product is as good as Pancreatic enzyme concentrate power.

AUGUST S Verified Purchase
June 8, 2021

great service good product

Tiffany B Verified Purchase
May 20, 2021

My dog is alive because of this so thank you from the bottom of my soul

Margo M Verified Purchase
May 3, 2021

Keeps our “girl” alive!

Iris E Verified Purchase
May 3, 2021

Amazing

Elizabeth R Verified Purchase
May 3, 2021

My schnauzer is thriving with this. She has EPI.

Diane s Verified Purchase
May 3, 2021

it helps my dog tremendously

Sesilie D Verified Purchase
April 26, 2021

Reasonably priced

Bobbi G Verified Purchase
April 26, 2021

Good product

Sandra F Verified Purchase
April 26, 2021

Great reliable service consistently

Aldina r Verified Purchase
February 2, 2021

because it helps shadow getting a normal life

Andrew H Verified Purchase
January 28, 2021

3 years ago, this product saved my little (big) boys life. He has gained back over 45lbs and is healthier than ever. He'll be 10 this fall.

Billie J Verified Purchase
November 23, 2020

Totally works!!!

CARL B Verified Purchase
October 20, 2020

Worry free delivery and product is quality made.

Sandra W Verified Purchase
October 2, 2020

Need this to ensure that my pet can eat.

Jami T Verified Purchase
October 2, 2020

My grandson's dog has EPI and needs this enzyme to live, as she doesn't produce her own pancreatic enzymes herself and cannot absorb the nutrients she needs to thrive. When he brought his dog home, she was skin and bones, wesk, her coat and eyes were dull. Now she's gained weight, she's playful, her coat is glossy and her eyes are bright. Thank you Allivet for making this more affordable.

Jami T Verified Purchase
August 10, 2020

It was recommended by our for our GSD that my grandson rescued from euthanasia. Not knowing much about EPI, and the testing, diet and enzyme replacement she'd have to get, I'm really glad she recommended PancreaPlus. Our GSD has gained 5 lbs in 3 weeks, has more normal stools, and is feeling more energetic. Still as sweet as can be.

Tammy T Verified Purchase
August 3, 2020

Took a while to get this medication. No fault of Allivet but on behalf of the vet I had. The customer service was amazing and extremely helpful especially with dealing with me and my nervous state of my dog not having her meds and possibly dying without them. So thank u Allivet!!

Jami T Verified Purchase
July 7, 2020

I bought Pancreaplus because my dog would probably die without it.

Tim W Verified Purchase
June 18, 2020

Keeps my 13yr old chihuahua Bella alive 👍

Cesar D Verified Purchase
June 18, 2020

my poor dude has Pancreatic problem so he needs to digest his food. It works really well been using for a while now.

Regina C Verified Purchase
May 22, 2020

I just started using PancrePlus. I pray it works. It smells funky and my dog won’t eat it on his kibble without mixing in some canned food. I found that Trippet canned tripe has a venison version that’s lower fat than the others. I’ve been using that, mixing in half a can with kibble and PancrePlus, and my boy’s been eating it up. The venison Trippet is lower fat, high protein, with the added benefit of Tripe, so it seemed a logical choice for my newly diagnosed EPI dog.

Tom E Verified Purchase
May 5, 2020

Product shipped in a timely manner

John G Verified Purchase
May 5, 2020

Keeping her alive

Stephanie Z Verified Purchase
May 5, 2020

This was prescribed for my German Shepard by his vet. I am getting an awesome deal with the auto re-fill and has helped my Loki gain weight. He was not gaining weight and his food was not processing right. We tried changing his food once we got the right testing done with is what our vet prescribed. It totally worked!

Lisa H Verified Purchase
May 5, 2020

This stuff is great! It’s working for my German Shep! No more loose stools. It took like a month to fully work so hang in there!

Tim W Verified Purchase
May 5, 2020

My 13yr old chihuahua Bella wouldn’t have lived past age 5 without this stuff.

Tammy C Verified Purchase
May 5, 2020

My fur baby was pretty sick with stomach issues. This product at the suggestion of the vet has put Kali back on track. She is doing much better and being her playful crazy self again. I am so happy.

Kay M Verified Purchase
April 7, 2020

This is the very best place to but quality pet meds and save money with every order.

LINDA G Verified Purchase
April 7, 2020

pricing

John W Verified Purchase
March 10, 2020

Great service & great value

Lynn w Verified Purchase
March 3, 2020

I purchase pancre plus for my 15 year old cattle dog which has been on this medicine since 6 mos. old. I give her 1 tablespoon daily in her food and she has done really well on it! She was diagnosed with pancreatic insufficiency as a pup.

Tammy C Verified Purchase
March 3, 2020

My cat is doing well with this product and my vet recommended it.

Steve J Verified Purchase
March 3, 2020

My GSD has EPI

Hannah S Verified Purchase
February 6, 2020

This has saved my babygirls life! She was literally starving to death in 2016 - turns out she has EPI and this med is essential to her livelihood!

Tammy C Verified Purchase
February 6, 2020

My vet suggested this medicine to help my cat with her newly found condition.

John W Verified Purchase
February 6, 2020

Great service and competitive pricing

Brian D Verified Purchase
January 27, 2020

Been using it on our German Shep. for years.

Terri C Verified Purchase
January 20, 2020

Awesome

Merilee B Verified Purchase
January 20, 2020

This is quality and shipped on time

Lena M Verified Purchase
December 4, 2019

Easy to reorder

Teri d Verified Purchase
December 4, 2019

Great product

Linda H Verified Purchase
November 21, 2019

Excellent

Mary C Verified Purchase
November 12, 2019

This product does a wonderful job of controlling my dog's EPI. She is once again the vibrant athletic dog she was before the onset of EPI.

Linda L Verified Purchase
November 6, 2019

Works great & immediately.

Thomas B Verified Purchase
October 28, 2019

PancrePlus worked very quickly. Britney regained her lost weight and normal appetite. We thought we may lose her, but she has regained her energy and is back to normal.

Tim W Verified Purchase
October 15, 2019

Simple, easy to maneuver website; have not had any problems getting my dogs medication. Fast free shipping as well. Thanks Allivet ~❤️

Rigobeto A Verified Purchase
October 10, 2019

this pancreplus have help my dog

Gail E Verified Purchase
October 10, 2019

A must have for my pet!!!

Joan D Verified Purchase
October 10, 2019

Great stuff!!

Kelsey M Verified Purchase
September 25, 2019

I purchased this because I have to..

Kay M Verified Purchase
September 17, 2019

My Jasmine almost died from pancreatitis before they diagnosed her. Once she went on this med she had a remarkable recovery and 5 years later is still doing well.

Hannah S Verified Purchase
September 17, 2019

My girl wouldn't be alive if it weren't for this!

Siggi J Verified Purchase
August 26, 2019

My dog has EPI

Linda L Verified Purchase
August 23, 2019

This product is amazing. My dog doesn't even seem to notice it's on her food. She is absorbing nutrients again & gained her weight back after losing half her body weight. we were really scared we were going to lose her. Thank you!!!

Siggi J Verified Purchase
July 31, 2019

My dog has EPI

Linda L Verified Purchase
July 16, 2019

Our dog tested positive for EPI Disease (Exocrine Pancreatic Insufficiency) we were told she needs this powder. She lost half her weight and had diarrhea & lots of flatulence. She was ravenously hungry. Hoping this works.

Linda H Verified Purchase
June 18, 2019

Good product helps pancreas break down food

Bonnie B Verified Purchase
June 6, 2019

The only enzyme that works for my Boxer with EPI

Sandra W Verified Purchase
May 10, 2019

For my dog to survive otherwise would not be able to digest anything

Deborah E Verified Purchase
May 7, 2019

Excellent service!

Olena T Verified Purchase
May 3, 2019

It's help to digest food

Nicole M Verified Purchase
April 25, 2019

dog needs it and cheaper then at vet. easy to order

Ralph G Verified Purchase
April 22, 2019

Been receiving this product from Allivet for about a year now and it has been great. Better price than the vet and it comes on a timely manner. Product does what it is suppose to do. Thank you.

SCOTT M Verified Purchase
April 2, 2019

This product saved my German Shephard's life!

SCOTT M Verified Purchase
April 2, 2019

This product saved my German Shephard's life!

AUGUST S Verified Purchase
March 11, 2019

Allivet makes getting pet medications so easy, and at a great price.

Jeanne D Verified Purchase
March 11, 2019

Makes loving my pup easy as pie

Deborah e Verified Purchase
February 26, 2019

My dog was diagnosed with Pancreatitis and the sonogram showed a black pancreas. We thought we lost her. After a course of prednisone and this mixed in with her food she is doing good. Seems like it works well as an enzyme to allow the pancreas to not have to work. Good price compared to vet and other online retailers.

Donna a Verified Purchase
February 15, 2019

My dog needs this medication in order to digest her food. In the past I had to order this medication from my vet. This is an excellent product. I am very happy with it. My dog is doing very well.

David W Verified Purchase
February 12, 2019

I have been using this produce for about 6 months. Keeps my pet's EPI under control. She has gained weight and has a lot of energy.

Robin M Verified Purchase
January 21, 2019

It deals with my dog's issue and has for many years.

Donna a Verified Purchase
January 15, 2019

I highly recommend Allivet, my experience has been wonderful. Their prices are reasonable and their staff is excellent. I ordered PancrePlus Powder for my dog and she is flourishing.

Sheila M Verified Purchase
December 19, 2018

Allivet is awesome! The prices are fair and the autoship is terrific. I never need to worry about running out of my kitty's medicine. Thanks Allivet for making it so easy. Hope you all have a happy holiday.

AUGUST S Verified Purchase
December 18, 2018

price is good

Diane A Verified Purchase
November 15, 2018

Excellent affordable product that works!

Nancy V Verified Purchase
November 13, 2018

He also can't digest foods without using PancrePlus, this product is keeping him alive.

Alison K Verified Purchase
October 29, 2018

My puppy has EPI, and will the rest of his life, (we found out shortly after he turned 1..) I have found it to be cheapest on Allivet, but wish it came in larger quantity as he needs 6teaspoons a day, i find myself buying a lot of little bottles often.

Amanda W Verified Purchase
October 2, 2018

All over has made ordering PancreaPlus so easy! My dog is so much healthier and happier thanks to Allivet!!!

Robin M Verified Purchase
October 1, 2018

My dog was diagnosed with Pancreas insufficiency quite a few years ago, and thankfully this product "does the trick"

Kay M Verified Purchase
September 12, 2018

I love this place!! I get my Jazzy Girls meds cheaper and very quick service..

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