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ProZinc Insulin for Dogs and Cats, 10 ml Vial
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ProZinc Insulin for Dogs and Cats, 10 ml Vial
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ProZinc Insulin for Dogs and Cats, 10 ml Vial
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Product Overview
PROZINC® (protamine zinc recombinant human insulin)
is the
simple and reliable choice for diabetes control in dogs and cats. It
is a veterinarian prescribed injectable insulin for cats and dogs. With just
two daily doses a day in cats and once-a-day dosing in most dogs, delivered
before or just after a meal, PROZINC insulin provides predictable glycemic
control in pets with diabetes.1,2 A
single PROZINC injection has an appropriate duration of activity (10-14 hrs) in
cats and an extended duration of activity (16->24 hrs) in dogs.3
If your cat or dog has been diagnosed with diabetes mellitus,
you understand the importance of regulating blood glucose and controlling
clinical signs. With its appropriate duration of action in cats, and extended
duration of action in dogs, PROZINC® insulin will provide glycemic
control and help improve the quality of life of your cat or dog.1, 2
PROZINC® insulin should only be administered to the
cat or dog for whom it was prescribed, and at the dosage and frequency for
which it was prescribed. If you have any questions or concerns about the
product or about diabetes mellitus, talk to your veterinarian. PROZINC®
insulin requires refrigeration,2 as well as the use of U-40 syringes,2
which are sold separately.
References:
1. Gostelow R, Scudder C, Hazuchova K, et al. One-year prospective randomized
trial comparing efficacy of glargine and protamine zinc insulin in diabetic
cats. In: Proceedings from the American College of Veterinary Internal Medicine
Forum; June 8–10, 2017; National Harbor, MD. Abstract EN10. 2. PROZINC®
(protamine zinc recombinant human insulin) [Freedom of Information Summary].
Duluth, GA: Boehringer Ingelheim Animal Health USA Inc; 2019. 3. Ward CR,
Christiansen K, Li J, et al. Field efficacy and safety of protamine zinc
recombinant human insulin in 276 dogs with diabetes mullitus. Dom Anim
Endocrin. 2021: 75.
ProZinc® (protamine zinc recombinant human insulin) is an injectable insulin for cats and insulin for dogs. PROZINC is an aqueous protamine zinc suspension of recombinant human insulin that is used to reduce hyperglycemia (high blood glucose or high blood sugar) and clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus.
For use in dogs and cats.
- FDA-approved first-line treatment for diabetes in cats, is available for use in dogs.1
- Extended duration of action of 16->24 hrs in dogs2
- Reduces hyperglycemia and hyperglycemia-associated clinical signs in both cats and dogs with diabetes mellitus 3,4
- Administered with pet-appropriate U-40 syringes4 (sold separately) to ensure accurate dosing and to minimize error
- PROZINC® (protamine zinc recombinant human insulin) has been rigorously tested for safety and efficacy in cats and dogs3
PROZINC® (protamine zinc recombinant human insulin) is an injectable insulin for cats and dogs. PROZINC® is an aqueous suspension of protamine zinc recombinant human insulin that is indicated to reduce hyperglycemia (high blood glucose or high blood sugar) and clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus.1, 2
PROZINC® works by helping your pet move all-important glucose from the bloodstream into the cells. Cats and dogs with diabetes mellitus don’t produce enough of their own naturally produced insulin, or their own insulin doesn’t work properly, and this causes glucose to build up in their blood, leading to health problems. PROZINC® becomes the essential replacement for diabetics to get their appropriate source of daily insulin.
Cats and dogs presenting with severe ketoacidosis, anorexia, lethargy, and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition is stabilized. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain and maintain adequate glycemic control and to prevent associated complications. Overdose can result in profound hypoglycemia and death. Glucocorticoids, progestogens, and certain endocrinopathies can have an antagonistic effect on insulin activity. Glucocorticoid and progestogen use should be avoided. The safety and effectiveness of PROZINC® insulin in breeding, pregnant, and lactating cats and dogs has not been evaluated. The safety and effectiveness of PROZINC® insulin in kittens and puppies has not been evaluated.
protamine zinc recombinant human insulin
Immediately contact your closest emergency animal hospital.
PROZINC® (protamine zinc recombinant human insulin) is for use in cats and dogs only. Keep out of the reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain and maintain adequate glycemic control and to prevent associated complications. Overdose can result in profound hypoglycemia and death. The most common adverse reactions were lethargy, anorexia, hypoglycemia, vomiting, seizures, shaking (dogs only), diarrhea, and ataxia. Many of the adverse reactions, such as lethargy, seizures, shaking (dogs only), and ataxia, are associated with hypoglycemia. The safety and effectiveness of PROZINC® insulin in puppies, kittens, or breeding, pregnant, and lactating animals has not been evaluated. PROZINC® insulin is contraindicated during episodes of hypoglycemia and in animals sensitive to protamine zinc recombinant human insulin or any other ingredients in PROZINC® insulin. For additional information, please see full prescribing information.
PROZINC® (protamine zinc recombinant human insulin) is available as PROZINC® 40 units per mL, 10 mL and 20 mL vials and PROZINC® Diabetes Care Kit Syringe-Dispenser/Sharps Container 100 0.3 cc or 1.0 cc U-40 Syringes.
Boehringer Ingelheim
This product is most effective when given during meals or immediately thereafter. It is suggested that injections are administered at a set time every day for the sake of managing steady glucose levels. NOTE* Contains U-40 insulin: Be sure to administer with according U-40 syringe.
USE OF A SYRINGE OTHER THAN A U-40 SYRINGE WILL RESULT IN
INCORRECT DOSING. FOR SUBCUTANEOUS INJECTION ONLY. DO NOT SHAKE OR AGITATE THE
VIAL. PROZINC® insulin requires refrigeration at all times.
PROZINC® (protamine zinc recombinant human insulin) should
be mixed by gently rolling the vial prior to withdrawing each dose from the
vial. Once mixed, PROZINC® insulin suspension has a white, cloudy
appearance. Clumps or visible white particles can form in insulin suspensions:
do not use the product if clumps or visible white particles persist after
gently rolling the vial. Using a U-40 insulin syringe, the injection should be
administered subcutaneously on the back of the neck or on the side of the cat
or dog.
FOR CATS:
The initial recommended PROZINC® dose is 0.1 – 0.3 IU
insulin/pound of body weight (0.2 – 0.7 IU/kg) every 12 hours. The dose should
be given concurrently with or right after a meal. The veterinarian should
re-evaluate the cat at appropriate intervals and adjust the dose based on both
clinical signs and glucose nadirs until adequate glycemic control has been
attained. In the effectiveness field study, glycemic control was considered
adequate if the glucose nadir from a 9-hour blood glucose curve was between 80
and 150 mg/dL and clinical signs of hyperglycemia such as polyuria, polydipsia,
and weight loss were improved.
Further adjustments in the dosage may be necessary with changes
in the cat’s diet, body weight, or concomitant medication, or if the cat
develops concurrent infection, inflammation, neoplasia, or an additional
endocrine or other medical disorder.
FOR DOGS:
Starting dose: The recommended starting dose for
PROZINC® is 0.2-0.5 IU insulin/pound of body weight (0.5- 1.0 IU/kg)
once daily. The recommended starting dose for naïve dogs is the lower end of
the dose range. The recommended starting dose for dogs with poorly controlled
diabetes mellitus and transitioning from another insulin product is the mid to
higher end of the dose range based on the veterinarian’s experience with the dog’s
medical history and previous insulin dose. When transitioning from another
insulin, the dog’s blood glucose and general condition should be closely
monitored. When transitioning from another insulin, PROZINC® insulin
should be started once daily, regardless of the frequency of prior insulin use.
The dose should be given concurrently with or right after a
meal. The veterinarian should re-evaluate the dog at appropriate intervals and
adjust the dose and frequency based on both clinical signs and laboratory test
results (the blood glucose curve values and shape, nadir, and fructosamine)
until adequate glycemic control has been attained. In the effectiveness field
study, glycemic control was considered adequate if the glucose nadir from a
9-hour blood glucose curve was between 80 and 125 mg/dL, the maximum blood
glucose was < 300 mg/dL, and clinical signs of hyperglycemia such as
polyuria, polydipsia, or weight loss were improved.
Changing to twice daily dosing: Twice daily dosing should be
considered if the duration of insulin action is determined to be inadequate
with once daily dosing. Use caution when adjusting from once daily to twice
daily dosing because PROZINC® insulin may have prolonged duration of
action in some dogs (see Clinical Pharmacology). The veterinarian should
closely monitor the duration of action using blood glucose curves to avoid the
increased risk of hypoglycemia. If twice daily dosing is initiated, the two
doses should each be approximately 25% less than the once daily dose required
to attain an acceptable glucose nadir. For example, if a dog receiving 10 units
of PROZINC® insulin once daily has an acceptable nadir but
inadequate duration of activity, the dose should be changed to 7 units twice
daily (round down to the nearest whole unit).
Further adjustments in the dosage may be necessary with changes
in the dog’s diet, body weight, or concomitant medication, or if the dog
develops concurrent infection, inflammation, neoplasia, or an additional endocrine
or other medical disorder.
Protamine zinc recombinant human insulin
About This Product
Customer Reviews
4.8
244 reviews
5
215
4
24
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Allivet is one of the few companies that offer ProZinc and reliable shipping services.
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Price and quality
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Much more cheaper than my Vet. Allivet was very easy to work with also. Will definitely use them in the future.
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Best price for insulin found anywhere
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Ease of website use and low cost.
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The insulin arrives in a timely manner and mostly in good shape.
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My cat needs this medication to live. Product arrives properly packaged and cold. could use better discounts, shipping is one third of the cost.
Verified Purchase
I trust Allivet to get my cat’s insulin to us in a safe and timely manner. We have used them for years and the shipment always arrives quick and in great condition. Insulin has to stay cool before, during and after transit and they package In a way that makes this possible. In fact, the ice packs are barely even starting to thaw when we open the package. I definitely recommend Allivet for your pets needs because they truly care!
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Allivet has excellent web services, quick delivery, and comparable prices. I have had good responses to questions and helpful customer service.
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ProZinc is affordable and seems to work the best to help maintain my cats health.
Verified Purchase
Very helpful in getting the product shipped and made sure I got the very best price possible. I will continue to purchase form Allivet and will recomend to my friends.
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My cat has diabetes, He's been using this insulin for two years now and it is absolutely perfect for him.
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It works well and keeps McCoy stable.
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Allivet is very responsive, my order came fast and their website is clear and easy to use.
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Service ++
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My review isn't so much about the product...tho' it is what my cat needs and he's doing well on it. This is what I want to share: last week I was expecting a (cold) shipment of this insulin. The carrier notified me that the package would be delayed a day, and when it arrived the contents were no longer cold. I emailed Allivet to see if the insulin would be compromised due to lack of ice. They replied that to be on the safe side, they would send out another vial. By the time I read that reply, the order was already enroute. It arrived nice and cold. I was just so impressed with the customer service! Thanks!
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Great service
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Great Customer service!
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Worked even after expiration date. Good stuff
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Costco is cheaper and no shipping cost
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Cheaper fast shipping A-ok product
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Insulin cheaper than in other places but shipping is expensive.
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Prozinc works for my cat. Best price I could find.
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Excellent
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My cat is a diabetic, he gets 2 shots a day. He is doing well on this insulin,
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Simple ordering and cost savings
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I cant see the difference when my cat gets his insulin shot
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Best price
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Best price on my cat’s insulin. Great service!
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I bought this for my diabetic Cat, Cole. It keeps him healthy and happy! It's pretty expensive, but he is priceless! :)
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Thanks guys your website always makes this process a breeze and the only time I had a problem your customer service was right on point!
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Was $44 dollars cheaper!
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Insulin is $40 less expensive than at my vet and $20 less expensive than other online providers. Even including the $29.99 shipping charge, using an online coupon, I still saved $15 over purchasing at my vet.
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Fast safe cold package shipping and the best price I have found for an expensive illness to manage.
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delivery to my home keeps pymt info on file so I can order when I remember, not needing my cc in hand
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Allivet is an excellent and reliable company to deal with I am on auto renew order and it comes promptly every month as promised. I couldn't ask for anymore
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This was my 2nd order, and I plan to stick with Allivet due to their reliable, prompt service and lower price. Both times, Allivet jumped on my order and shipped immediately. Because Insulin is temperature sensitive - I was pleased to see it arrived the very next day, still cold, and packed in quality cold pack boxes. Can't beat that kind of service!
Verified Purchase
When you insert the syringe in the top of the vile, the rubber top is kind of hard to get the syringe into it, so you have to be really careful not to bend the syringe. Other than that its ok.
Verified Purchase
Prompt hassle free shipping of my cat's life sustaining medication.... Thanks!!
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I never imagined my maltipoo would suddenly get diabetes and go blind! Allivet helps relieve the stress of keeping a constant stock of insulin, syringes and eye drops of the daily routine to keep Vinnie feeling as happy and healthy as possible. Thanks to all the reliable people who take their jobs seriously — and charge less than ANYwhere else I could find! -xo, Angela & Vinnie
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ideal product for my senior kitty
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This is the second cat I have had to treat with insulin. The 1st went into remission...whew! I am hoping the same for this one. The Prozinc has worked well for both so far.
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please just place the order
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Ordered on Friday and received on Tuesday of Labor Day weekend great service and prompt shipping
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Allivet price with refridgerated shipping cost less than veterinarian price. Products ship timely, and reordering is a breeze on Allivet site.
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This is a trusted pharmacy with best prices for my pet's insulin needs
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Allivet is reliable on shipping, reasonable on prices and the site is very user friendly. Using Allivet makes my life so much easier!
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Good price for insulin for my cat.
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Same insulin from my vet at a fraction of the cost.
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Great price & convenient.
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good product great price
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Allivet was priced much lower than other pet pharmacies on my kitties medicine. I'm so glad I found Allivet they offer the best price on many great products that your pet needs.
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Ordering my cats insulin was easy and arrived the exact day it was supposed to. was cold shipped and packed well. I've ordered form Allivet before , so i knew things would go smoothly as per the usual.
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I bought because it was the best price I could fine. My cat need.s 2 shots a day, so this becomes very costly.
Verified Purchase
My cat was recently diagnosed with diabetes. Allivet was the cheapest price around. This was the 2nd time ordering from Allivet, and for the 2nd time I had Fast delivery. I will use again & again as I just ordered for the 3rd time for a dog that requires a RX drug for pain. THANK YOU ALLIVET.
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This is the best for Missy
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Excellent price on insulin for cats, especially since I employ the autoship discount. Ships quickly to preserve potency.
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Because its about 1/2 price compared to my vet
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My only issue with this product is the high cost (Allivet is the cheapest source I've found so far)
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Reasonable price; quick service.
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My cat was recently diagnosed with diabetes. Allivet has the best price on the insulin he needs.
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Shipped overnight with enough ice packs to keep it cold for days. Great service!
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Excellent PZI! Works Great!
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prices are great
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I like their fast service and prices.
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Best price
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Great service!!
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The pharmacies kept raising the price on my cat's insulin and syringes, this way cost much less and was much easier than dealing with a pharmacy!
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Recently diagnosed kitty requires this drug. My first bottle was running out and I thought it would be easy to just pick up but was not available in local pharmacies. Thankfully, I was able to place an order (as a new customer) on Saturday, and had the new bottle on hand on Wed before mine ran out. They kept me appraised of the prescription verification process and shipping status throughout, so I didn't worry that I wouldn't get it in time. The overnight S&H was pricy, but arrived cold and in good shape. Good job, Allivet!
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Fast delivery, best price! Happy pet mama!
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even with shipping i saved $60.00!
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I have a diabetic feline and after much searching on line for products that I need to address my kitties special needs and many available companies. I found ALLIVET too be one of the BEST, efficient, reliable, price conscious competitor around! Thank you ALLIVET for the opportunity and faith I have as a consumer to purchase as many of the product I need from you. With Warm Regards, Sandra W.
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Best price!
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I'm impressed! First time I ordered from Allivet. Best price I could find for cat insulin. They took care of contacting my vet and the product arrived super-fast with superb packaging.
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My cat has diabetes.
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Great price and fast delivery
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Great product
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I'd been paying over $200 a bottle at my vet. The price here is amazing, and shipping was fast. This is life-changing for me and my cat!
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I've purchased insulin for Grey from my veterinarian since he was diagnosed almost 3 years ago. The first bottle was $130 but since then the cost has increased quite a bit. I searched the web and found several places that sold ProZinc at a variety of prices. Allivet was one of the lowest prices I found and had the best reviews so I decided to trust Allivet to provide my insulin for Grey and am confident they won't let me down!This is my first purchase with them but I'm sure I will make more purchases if they are as dependable and consumer friendly as they seem to be!
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Um.. because my cat is diabetic.
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My cat is diabetic, so this is a prescription for him.
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great
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Great service! I have two diabetic cats and this is the cheapest price ever!
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Allivet has the lowest price and ships the item cold. I was skeptical to buy refrigerated items in the mail but I am very impressed with the service! Highly recommended.
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Easy to order and receive. Great price.
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Purchased for my newly diagnosed cat. cost is less than if I purchased through my local animal clinic
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Don’t have to wait long once ordered. Shipment came next day in a cold shipment box!
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Fast service. Great price.
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ProZinc is expensive, so buying it through Allivet is cheaper than at the vet. Even including the cold shipping, it saves me money! It is also so convenient to have it on automatic shipping.
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Good prices fast shipping excellent customer service
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Great prices
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very easy website to navigate
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Fast service at good price.
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Works well for my sensitive cat.
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It's good but wayyyy too expensive.
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Good price of the product, but that "discount" quickly goes away when you have to pay $29.99 on shipping. Not such a good deal in the end.
Verified Purchase
My other kitty 3 years ago used human insulin, and it worked well, but the ProZinc has been wonderful for TT. Excellent product and easy to regulate with no issues. After 4 months she is still doing so well. Her weight is up to 7 pounds after being at 5 ans her blood sugar is stable. she is 20 so her being this happy and stable again means the world to us. Allivet is wonderful as well. Their customer service is first rate and do everything to accommodate their customer. The insulin was amazing packed in cold packs and arrived in 24 hours, ready to go. They even found a way to pack my needles in the same order which was perfect!!! Thank you. Bernadette L.
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The insulin was fine, though the ice had just about melted when it arrived late in the day. What really bugged me was the WEEKS of back and forths implying my vet wasn't responding.. and Allivet not having good communication with me about why my package wasn't showing up... let alone them calling the wrong number and using the wrong fax for the vet on multiple occasions. The whole idea of confirming by fax is archaic. Get with the times and develop better communications protocols, please!
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Wow, easy to navigate site, large selection of RX supplies, fast checkout and timely delivery with follow-up. Perfect
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Great!