Administration : A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying SelaSpot topically prior to first use. Firmly press the cap down to puncture the seal on the SelaSpot tube; a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of SelaSpot against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of SelaSpot against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of SelaSpot against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse.