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Simparica Chewable Tablets for Dogs

By Simparica
(797 reviews)
Veterinary Diet Item
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Simparica Chewable Tablets for Dogs

By Simparica
$145.25
One-time purchase
$125.25 AutoShip & Save up to 40%
Availability:
  • In Stock

Prescription needed

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Weight and Color: 88 - 132 lbs Brown
Month Supply: 6 Month Supply
Weight and Color: 88 - 132 lbs Brown
Month Supply: 6 Month Supply
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Product Overview

Simparica is a safe, monthly chewable tick and flea preventative for dogs. Available by prescription, it works quickly and provides an entire month of protection. It goes to work killing ticks within 8 hours and fleas within 3 hours, maintaining its effectiveness for up to 34 days.
For dogs ages 6 months and up.
Features of Simparica:
  • Protects against ticks and fleas for a full month
  • Rapidly relieves existing flea infestations, even for dogs allergic to fleas
  • Improves clinical signs of flea allergies by killing fleas
  • Kills fleas before they lay eggs, controlling and preventing flea infestation in your home
  • Kills ticks quickly, helping to reduce the risk of life-threatening tick and flea-born diseases
  • Easy to administer
  • May be broken up and combined with food or administered directly
The active ingredient in Simparica is sarolaner, which inhibits the function of the glutamate receptor and neurotransmitter gamma aminobutyric acid (GABA) receptor and works in insects at the neuromuscular junction. This leads to acarine or insect death caused by uncontrolled neuromuscular activity.
Most common side effects include diarrhea and vomiting.

Simparica may also cause abnormal neurologic signs, including:
  • Decreased conscious proprioception (body movement and position awareness)
  • Tremors
  • Absent or decreased menace (blinking reflex)
  • Ataxia (loss of full control of bodily movement)
  • Seizures
Sarolaner
Contact your closest emergency animal hospital or veterinarian.
Keep out of reach of animals and children.

Not approved for safe use in lactating, breeding, or pregnant dogs.

Not for human or cat consumption.

Should not be administered to dogs under 2.8 pounds or under 6 months old.
Simparica tablets are sold in a 3 monthly supply of 3 tablets or a 6 month supply of 6 tablets dependent on your dogs weight.
Zoetis
For continuous protection, it is recommended to administer Simparica at the same time each month.

Simparica may be given with or without food.
Encourage your dog to chew, rather than swallow their dosage (1 tablet) of Simparica. If your dog commonly swallows treats whole, you can break the tablet into pieces. Ensure that your dog consumes the complete dose. If you suspect that a full dose wasn't consumed, redosing is recommended.
Simparica is manufactured by Zoetis and contains the active ingredient sarolaner.

Product Label Color / Dog’s Weight / Amount of Sarolaner per Tablet
Yellow                         2.8 - 5.5 lbs                         5 mg
Purple                          5.6 - 11 lbs                        10 mg
Orange                       11.1 - 22 lbs                        20 mg
Blue                            22.1 - 44 lbs                        40 mg
Green                         44.1 - 88 lbs                        80 mg
Brown                       88.1 - 132 lbs                      120 mg

About This Product

Customer Reviews

4.9
797 reviews
5 781
4 16
3 0
2 0
1 0
Customer review photo
Customer review photo
Paul H Verified Purchase
October 13, 2026

Works for MacDougall

My beautiful Golden Boy loves the woods and in the south that means fleas and ticks come with the territory. In the five years he has been on Simparica he's never had even one.

Candace A Verified Purchase
September 14, 2026

No unwanted pests. Easy peazy!

Trena E Verified Purchase
September 10, 2026

Works like a charm!

Shannon H Verified Purchase
August 25, 2026

Super easy and way cheaper than I have found elsewhere

Diann G Verified Purchase
August 20, 2026

Flea prevention

The only preventative I use. I have tried other brands and nothing works as well.

Bethany B Verified Purchase
August 17, 2026

Simparica does the job!

Simparica has proven to prevent flea and tick issues. My dog eats it with no problems and has not had any pest problems. Will use again!

Sonia C Verified Purchase
August 6, 2026

Excellent for my furry kids. Have been using this product for many years

Lisa T Verified Purchase
August 4, 2026

I love this product.

SIMPARICA chewables are the best product for fleas and ticks. I live in an area where there are many fleas and ticks on our property. I have not pulled one off of my dog this summer because he has been taking the Simparica.

Lisa P Verified Purchase
July 21, 2026

Great product!

I still notice my dog acting like there's a flea but I have yet to see one and the groomer said there were no signs of any. Going on that, I'm believing this product is the reason why. So far, I'm very satisfied!

Kathy M Verified Purchase
March 27, 2026

Have used this product for years. It does a great job protecting/preventing any issues with bugs/insects . Living in very wooded area/environment

Leticia H Verified Purchase
June 20, 2025

The only flea med that works

No other medication has taken care of fleas on my dogs. I don't have to spray my house, no collars needed, it's perfect.

Terri A Verified Purchase
June 14, 2025

Flea and tick cure!

Very easy to order, and discounts are a plus! In todays expensive world, caring for our beloved pets can be very expensive. Getting a price cut is everything!

James S Verified Purchase
June 8, 2025

With Simparica we don't have to worry about flea treatment for our house cats because the dogs are flea free. That's the biggest plus for us -- not having to treat 5 cats for fleas!

Anonymous Verified Purchase
May 23, 2025

Smparica

I will leave this up to your personal preference, but I have used Simparica on my dogs, one tablet every other month, and have never found a flea or tick on them. We are in the woods several times a year and still no ticks or fleas.

Reba C Verified Purchase
May 21, 2025

Long time user of this product for our schnauzer. Has been very effective. And most surprising is how she will chew each tablet up without complaint. Continue to be pleased with this product and have had no ill effects.

Ashton F Verified Purchase
April 11, 2025

Works!

I've had to give my dog medicine for other things and it is literally a nightmare, but these Simparica Chewables are like treats. I don't have to hide it in anything or shove it in her mouth. I just treat it like a treat and have her sit and shake and then give it to her and she eats it right up. Takes the stress out of monthly medication.

Gerard G Verified Purchase
November 8, 2024

Excellent product, since I started using this, my dog hasn't had any fleas anymore. He does not like the taste but I pulverize it and add it to his food.

Barbara A Verified Purchase
September 7, 2024

I have a Yorky that’s 4 1/2 pounds who was very sensitive to other flea And tick Preventatives. And with great trepidation I tried one pill of the Simpatica Trio, which tolerated well I am purchasing from this company, even though I had a long Standing relationship with another because the pricing is amazing on a subscription level and because of their efficiency. I am very particular with this little dog since she’s 11 years old and has some other issues. And also because I’m crazy about her lol

Theresa G Verified Purchase
August 26, 2024

My dog has bad flea allergies here in Fl so she can’t go without this tablet. I can tell when it’s due so it’s been a miracle medication for our girl.

Gladys S Verified Purchase
July 29, 2024

I've been using this product since they were pups. Haven't had any issues with fleas or ticks. It's costly but worth it.

Michelle M Verified Purchase
July 23, 2024

This actually gets rid of Dog lice instead of the liquid treatments that claim to work but they do not! You have to give it once a month for at least 6 months to be sure the eggs that hatch and make their way onto your dog over the next several months get killed as well. If dog lice is a problem in your area, like in Las Vegas, then your dog needs to stay on it every month to prevent them from ever getting it again. This stuff is a miracle!!!!

Darlene M Verified Purchase
July 16, 2024

Works great! Our little guy never has a flea on him even though we take him to a dog park where there are several other dogs. He’s very finicky about what he’ll eat but has no problem at all chewing this pill.

Teresa B Verified Purchase
July 12, 2024

Simparica always keeps my American Pit Bull Terrier flea free all year long. She has been on Simparica for almost 5 years. Great product. And good service with Allivet on delivery.

Allyson C
July 12, 2024

My Yorkie has been taking Simparica for more than a year and seems to be doing very well with it. Although he still gives us trouble getting it down every now and then, this is the most consistently accepted supplement we have given him.

Wendy C Verified Purchase
June 27, 2024

My 10.6 lb Cavapoo has done well with this medication. She loves the taste and doesn’t have any problem taking it. A day or two after, her stool is a bit softer, but otherwise she doesn’t have any physical symptoms. I know all dogs are different, but she tolerates this very well.

Joelle C Verified Purchase
May 8, 2024

Simparica keeps fleas and ticks off of my sweet Polly and she gobbles it up, no problem. It also protects her from parasites.

Theresa S Verified Purchase
April 10, 2024

It's easy to administer and saves my dog from taking multiple flea and tick an heartworm medications

Gigi M
February 9, 2024

I’ve been giving this to my two 80lb pitty mixes and I feel confident that it is protecting them plus I have it on autoship so no worries I’ll miss their monthly dosage.

Reta S Verified Purchase
January 23, 2024

Our small 3 lb puppy has well tolerated this product so far. Our vet had recommended this brand as a good product for both of our dogs, as we live in an area of S. California with the highest rate of fleas and ticks in the nation (all year round)-- and they have become resistant to our old over-the-counter tick and flea medication. We were forced to switch due to this problem-- and have been pleased so far.

Charles B Verified Purchase
December 15, 2023

I have tried just about every flea treatment on the market and Simparica is my absolute favorite for my precious babies! It is fast acting and effective. It even keeps mosquitoes from biting! My only complaint is I wish they made it for cats as well! I highly recommend this product, especially for multi pet households!

Tyrone G Verified Purchase
October 27, 2023

I love using Simparica for my dog because of the ease with administering the dose. She takes right to it!

Kim L Verified Purchase
October 25, 2023

Unbelievable results, have never seen a Flea or a tick on either of our dogs.

Cherrie B Verified Purchase
June 28, 2023

Works well with my pup. She loves the taste and it doesn't leave sticky residue on her back. The price at Allivet is the best. Great deal all around!

Susan O Verified Purchase
May 26, 2023

Convenient all in one protection

Debbie H Verified Purchase
May 1, 2023

Works great . No issues with fleas or ticks

Victoria C Verified Purchase
March 16, 2023

Easy to administer; dog loves them. Easy to order.

Francisco C Verified Purchase
March 3, 2023

very good product! my chihuahuas are itching free and better fur without rashes of any kind

Julie S Verified Purchase
January 1, 2023

Great product and reasonably priced

Kit p Verified Purchase
December 14, 2022

My dog has been taking this because of his inability to have flea medicine on his skin. He will only take it in a pill pocket.

Arturo R
November 16, 2022

This product works better than anything we have tried previously. Our dog has no side affects, unlike he has with other products, and it must taste great because he acts as if he is getting a treat!

Barb Q Verified Purchase
November 16, 2022

Excellent price and service from Allivet for product

Han s
November 7, 2022

The best one recommended by my vet. My dog easily takes it..

Casey S Verified Purchase
October 24, 2022

Always the best price. Prompt and efficient

Terry C Verified Purchase
October 21, 2022

Service is Great and the price is lower than if I had to get it from the vet

Guy W Verified Purchase
September 21, 2022

This is the best price I’ve found for Simparica

Roger W Verified Purchase
September 9, 2022

This is one of the best flea and tick meds on the market. Very happy.

Linda M Verified Purchase
June 24, 2022

I love using Allivet, they send me reminds and will contact my vet for me. Very pleased with the service.

Carla F Verified Purchase
June 23, 2022

My Rosie loves taking these chewable tablets, plus it helps with preventing fleas. YAY!!! Happy pet makes a happy Mom! No itching!!

Steven H Verified Purchase
May 19, 2022

Great product dog thinks a treat. Have been using for years never had a flea or tic problem.

Kelly S Verified Purchase
March 31, 2022

cheapest price around.

Kelly S Verified Purchase
March 31, 2022

cheapest price around.

Matt G Verified Purchase
March 31, 2022

Great service & fast delivery!

Christine B Verified Purchase
March 31, 2022

Rocky thinks it is a treat and it works

Richard M Verified Purchase
March 31, 2022

Positive past experience brings me back. We have 3 dogs, and they keep them all straight

Christine B Verified Purchase
March 31, 2022

Bugsy thinks it is a treat and it works

Rose M Verified Purchase
March 24, 2022

stops and prevents fleas and ticks

Angel L Verified Purchase
March 24, 2022

Price are way lower than my Vets!

Angel L Verified Purchase
March 24, 2022

Price are way lower than my Vets!

Gary H Verified Purchase
March 18, 2022

Works very well with no side effects. Would recommend to anyone with a small dog. I own a Carkie. Best dog ever. Very loving ❤️.

Gayle W Verified Purchase
March 10, 2022

Because we live in an area that leaves my dog vulnerable to parasites, my vet prescribed this to protect her.

Francisco C Verified Purchase
March 3, 2022

Best product for my dog! who's very allergic to the bites of the fleas

Eileen n Verified Purchase
February 24, 2022

My dog actually looks forward to these when I tell her it's time for medicine! Price beats all other vendors.

Juanita E Verified Purchase
January 31, 2022

I frequently go into areas with both dogs and have never had an issue with fleas or ticks thanks to Simparica

Brian M Verified Purchase
January 25, 2022

Live in GA, this brand works great

Perry B Verified Purchase
January 25, 2022

Easy to order and fast delivery. No hassles.

Stan T Verified Purchase
January 25, 2022

I didn't know ALLiVet existed until I choked on the price at WalmartPetrx. AlliVet is $35 less for the same exact product! That's more money saved for other pet expenses.

Patty V Verified Purchase
January 25, 2022

I have used Simpatico for years now. Only product on the market that actually does what it says. Ticks get on my dogs but die and never dig in resulting in two healthy labs!

Selma J Verified Purchase
January 25, 2022

absolutely love this brand no fleas

Barb Q Verified Purchase
January 22, 2022

Allivet has excellent prices and service. I highly recommend purchasing from them.

Delores R Verified Purchase
January 18, 2022

I have been giving Simparica to my 10 lb Maltipoo rescue for over 2 years. He has done well with the med: no adverse reactions, no problem administering it. I plan to continue the same. med; no adverse reactions. I plan to keep him on the same regime

Barbara H Verified Purchase
December 14, 2021

HIGHLY recommended by a very respected vet!!!

Colleen G Verified Purchase
December 14, 2021

My dog always hated getting topical treatments, and I never loved the smell of them myself. After talking to her vet they mentioned that we could try an oral treatment instead and now we've been using Simparica for years and she's been pest-free!

Suzanne G Verified Purchase
December 8, 2021

Simparica tablets work great and my dog has no problem taking them. She thinks they are treats. She has been free of fleas since I started her on these tablets 3 years ago. Allivet makes it very affordable and easy to order.

Gladys S Verified Purchase
November 22, 2021

I've been using this product for several years and it works. Have had no problems, and flea & tick free.

Liz E Verified Purchase
November 22, 2021

My dogs love them don’t have to fight to get them to take it. I trust the product.

Jeanette L Verified Purchase
November 15, 2021

Great prices

Priscella M Verified Purchase
November 11, 2021

This stuff is great, kills ticks and fleas in no time at all and keeps them gone for 30 days! This stuff is a must have for all furbabies.

Priscella M Verified Purchase
November 11, 2021

This stuff is great, kills ticks and fleas in no time at all and keeps them gone for 30 days! This stuff is a must have for all furbabies.

Sheryleen G Verified Purchase
November 11, 2021

When comparing prices for Miller's flea Rx, I found Allivet's prices beat the rest. The Simparica arrived on time. Free shipping makes it an even sweeter deal.

Danielle H Verified Purchase
November 3, 2021

Our dogs love the taste and it works great!

Donald a Verified Purchase
November 3, 2021

always on time..and price is very good

ALYSIAQ Q Verified Purchase
October 18, 2021

LOVE THESE CHEWS MY DOG THINKS THEY ARE TREATS

Julia P Verified Purchase
October 7, 2021

Because I live on a fixed income and the price is very affordable to me.

Rosa A Verified Purchase
October 6, 2021

works for my puppy

Stella D Verified Purchase
October 6, 2021

Easy to give tablets and dogs love it.

William N Verified Purchase
September 23, 2021

Our puppies eat this product like it's a treat. Allivet t is easy to deal with insuring that we always have this available.

Mark D Verified Purchase
September 7, 2021

I already use Simparica, allivet had a great price. I ordered twice the amount that I would have got from Chewy for the same price.

Karen R Verified Purchase
August 24, 2021

Safe, effective and no worries about fleas/ticks.

Francisco C Verified Purchase
August 23, 2021

This has been the very BEST of the BEST for my dog. Bye bye fleas and all the issues associated with them on the skin, etc. Thank you Simparica!

Tyler B Verified Purchase
August 23, 2021

Just what we need to keep the fleas away!

Brett s Verified Purchase
August 18, 2021

its great once a month done

Douglas m Verified Purchase
August 15, 2021

good product

CECILIA D Verified Purchase
August 12, 2021

You had the cheapest price. Can't complain about that!

Andrea B Verified Purchase
August 5, 2021

Best Price

Randall W Verified Purchase
August 2, 2021

I love the all in one. Makes it so easy to give to my dogs. I was using seresto collaes and heartguard. With the seresto collaes they would chew them off each other or someone would lose one then my younger dog developed an allergy. No problems with this though!

Deborah E Verified Purchase
August 2, 2021

great prices

Shannon C Verified Purchase
July 25, 2021

Great product

Jonathan S Verified Purchase
July 23, 2021

Fast and easy

Cynthia B Verified Purchase
July 23, 2021

great price

Elizabeth B Verified Purchase
July 23, 2021

Great product!

Questions & Answers