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Trifexis Chewable Tablets for Dogs

(2,947 reviews)
Veterinary Diet Item
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Trifexis Chewable Tablets for Dogs

$77.05
One-time purchase
$57.05 AutoShip & Save up to 40%
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Weight and Color: 5-10 lbs Pink
Month Supply: 3 Month Supply
Weight and Color: 5-10 lbs Pink
Month Supply: 3 Month Supply
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Product Overview

Beef-flavored Trifexis (spinosad + milbemycin oxime) chews are prescribed to eliminate fleas and keep flea infestations from happening. They also protect against heartworm disease as well as treating and controlling infections of adult hookworm, whipworm, and roundworm in dogs.

Because Trifexis chewable tablets are beef-flavored, so your dog will think you are giving him a treat. The convenience of flea control medicine, heartworm prevention, and intestinal parasite control in one flavorful flea and tick pill lets pet parents rest easy knowing their furry companions are protected.

Your pet must be tested for heartworm before administering Trifexis tablets for dogs. This is an important test and helps protect your pet from heartworm and ensures they get the correct treatment.

The use of Trifexis chewable tablets for flea and parasite control in breeding males has not been evaluated, so it is not recommended at this time. Talk to your veterinarian about appropriate flea control products for breeding males.
Trifexis is for dogs and puppies 8 weeks of age or older. Trifexis should not be used on puppies or dogs under 5 lbs.
When used monthly and in line with the directions on the label, Trifexis kills any fleas on your dogs before they have a chance to lay eggs and reproduce. All animals in your household should be treated with a flea product approved for their species to keep the flea population under control. Your dog may be exposed to fleas either during walks outside, visits to the dog park, or by visiting other dogs. If fleas jump onto your dog and bite them, they are killed by Trifexis, so that they do not reproduce and infest your dog and your home. This happens every time a new flea jumps on your pet, as long as you give them Trifexis tablets for flea and parasite control. If you have administered Trifexis correctly and see intestinal worms in your dog’s stool, do not worry. This indicates that Trifexis is doing its job in keeping your pet parasite-free by expelling the parasites. If you have any concerns about this, contact your veterinarian.
  • In one monthly tablet, Trifexis prevents flea infestations and protects your dog from parasites.
  • Spinosad (primary ingredient) kills adult fleas, preventing flea infestation.
  • Spinosad targets activation of nicotinic acetylcholine receptors (nAChRs) in insects.
  • Begins working in 30 minutes.
  • Proven to kill 100% of all biting fleas.
  • Milbemycin Oxime (active ingredient) is used to prevent heartworms and kill immature heartworms.
  • Milbemycin Oxime kills adult hookworms, roundworms, and whipworms.

The most common side effect of Trifexis chewable flea control is vomiting. However, there are some other adverse reactions you should know about if you are considering giving Trifexis to your dog. If these side effects become severe or concerning, contact your veterinarian.

Additional side effects of Trifexis include:

  • Itchy skin
  • Redness of skin or ears
  • Loss of appetite
  • Lethargy
  • Diarrhea

If your dog is taking other medications in addition to Trifexis, talk to your veterinarian, some medications can react badly with Trifexis.

If your pet is allergic to Trifexis, they may have symptoms like seizures, scratching, hives, vomiting, sudden diarrhea, shock, cold limbs, pale gums, or coma. If your dog has any of these symptoms, speak with your veterinarian or an emergency veterinarian right away.

Your veterinarian should know about any other medical issues your pet has, especially epilepsy. Some conditions may make it unsafe for your dog to take Trifexis. It may not be appropriate for pregnant dogs or very young puppies. Safe use in breeding males has not yet been evaluated.

As with any medication, there is a chance your dog may have an allergic reaction that leads to anaphylaxis. If you notice any signs of an allergic reaction, contact your veterinarian right away.

Spinosad and Milbemycin Oxime
In the event of overdose or adverse reaction while using Trifexis, contact your closest emergency pet hospital.
Before starting Trifexis, your dog should be tested for heartworm infestation.
Use with caution in dogs with pre-existing epilepsy.
Trifexis has not been evaluated for safe use in breeding females.
Trifexis cheweable tablets for dogs are sold in 1, 3, 6, or 12 month supplies based on your dog's weight. Boxes are color coded to weight.
  • Trifexis Pink: 5-10 lbs
  • Trifexis Orange: 10-20 lbs
  • Trifexis Green: 20-40 lbs
  • Trifexis Blue: 40-60 lbs
  • Trifexis Brown: 60-120 lbs
Elanco Animal Health
For full heartworm prevention, ensure your dog gets three monthly doses after his/her last exposure to mosquitoes.
Trifexis doesn't require you to isolate your dog from other pets during treatment.
Trifexis is a prescribed pet medication for the prevention of fleas and parasites such as roundworm, hookworm and heartworm. Follow your veterinarian's directions on when to give this medication. If you are advised to give it seasonally for heartworm prevention, remember to give it during the mosquito season and 3 months beyond, preferably on the same date each month.

Trifexis should be used as recommended by your veterinarian. If you have difficulty giving the medication to your dog, contact your veterinarian. 
 
Dosages of Trifexis by Weight for Dogs Over 8 Weeks of Age

Weight                  /                       Dosage
5-10 lbs                             1 Tab (Pink Label box)
10.1 - 20 lbs                    1 Tab (Orange Label box)
20.1 - 40 lbs                     1 Tab (Green Label box)
40.1 - 60 lbs                     1 Tab (Blue Label box)
60.1 - 120 lbs                  1 Tab (Brown Label box)
Over 120 lbs                    Vet’s Prescribed Dosage

If you do not administer Trifexis monthly throughout the year, the final dose must be given no fewer than three months following the last exposure to mosquitoes. Please speak with your vet for any question regarding Trifexis dosage or missed dosages. 

Trifexis is manufactured by Elanco Animal Health and contains the following active ingredients:

Active Ingredients           /             Amount per Tablet
Spinosad                                                140 mg
Milbemycin Oxime                                2.3 mg




About This Product

Customer Reviews

4.9
2,947 reviews
5 2623
4 265
3 29
2 0
1 29
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Customer review photo
Customer review photo
Moyra S Verified Purchase
October 8, 2026

Easiest way to protect my Little Girl that I love with my life.

Christine G Verified Purchase
September 25, 2026

No bugs!

My dogs are 7 and 5 years old. They have both been taking Trifexis since they were old enough to take it and neither of them have ever had a tick, flea or any kind of worms. It's a little pricey but for that I'll do it.

Becky S Verified Purchase
September 22, 2026

Very satisfied

Been using this for almost 2 years on my dogs and I am very satisfied! Never any fleas or ticks and they spend a lot of time outdoors at parks around other pets.

Larry C Verified Purchase
September 16, 2026

Heartworm Protection

This heartworm, flea and tick protection pill has been great. There have been no issues with worms and have never spotted a flea or tick on my dog and we have been giving to him for years. A wonderful product but a little pricey. However worth the cost for keeping our family member healthy. Thank you 🙂

Maureen C Verified Purchase
September 11, 2026

Bessie

My dog has been taking Trifexis for years & has never had a problem with flees.

Janeth S Verified Purchase
August 25, 2026

Works grest

I gave all four of my mini Schnauzer’s trifexis once a month without any problems! Great price too

RONALD D Verified Purchase
August 19, 2026

my dog has been on TRIFEXIS for over 3 years. love this product.

my dog has been on TRIFEXIS for over 3 years. love this product

Stephen Y Verified Purchase
August 6, 2026

Trifexis Chewable for dogs

We have had no fleas or ticks on our dog after starting our dog on Trifexis!

Karla A Verified Purchase
July 30, 2026

Vet highly recommends

My long hair Dachshund loves these chews as they don't require being disguised, and they have kept him healthy.

Jody R Verified Purchase
July 29, 2026

Dog doesn't Like

Our dog doesn't like these, so we have to hide them inside other food to get them to eat it. As far as we know they are working. They have never coughed or showed any signs of heartworms. The mosquitos don't bother them. I am not sure about if it's suppose to help with ticks, but it seems to. Our dog is 12 years old and has been taking them most of those years.

Isabel S Verified Purchase
July 28, 2026

My dog is not crazy about the taste or smell but I hide it with some almond butter...

Catherine H Verified Purchase
May 1, 2026

BENEFITS RECEIVED FROM TRIFEXIS

HAVE BEEN GIVING TRIFEXIS TO MY POOCH FOR SEVERAL YEARS. THE BENEFITS ARE VISIBLE - SHE'S NEVER EXPERIENCED FLEAS OR TICKS. TRIFEXIS IS GIVEN ON THE FIRST OF EVERY MONTH AT MEALTIME. ALLIVET HAS PROVEN TO BE A RELIABLE SURCE & CHEAPER THAN ANY OTHER ONLINE SOURCE. THANKS TO ALLIVET.

Dawn G Verified Purchase
October 17, 2025

My Dog has been on it for 8 years and no issues. Doesn’t cover ticks but it’s cheaper and we don’t have a issue with ticks so I’ll take the savings

Robert M Verified Purchase
October 17, 2025

Trifexis

Our dog has been on Trifexis for years. It works great. Unfortunately, our dog hates the taste so it's always a battle to get it down.....cutting it up and covering it with peanut butter seems to work the best.

Laurie A
October 14, 2025

This product always works well and instantly for my puppy. He easily chews it up, so very easy to administer. And the vet always gives him a "thumbs up" exam with it doing its job towards fleas, ticks and heart worms. Have used it for years with my other dogs too. Highly, highly recommend.

Yuri S Verified Purchase
October 10, 2025

Reliable

I like Trifexis because it is one pill to prevent both heartworm and other lesser pests. Millie loves the pill, so no problem giving it to her. Once a month and no worries.

Nancy C Verified Purchase
September 15, 2025

The overall effectiveness of the product, combined with exceptional communication and service from the company, deserves a five-star review.

This year, I encountered a significant issue with fleas for the first time. Typically, after a flea bath and the application of a topical treatment, I would see quick results. However, this time it was different. I decided to give my pet Trifexis, and to my relief, it was effective. Within a week of treatment, the fleas were gone.

Ralph C Verified Purchase
July 4, 2025

My Yorkie has been taking Trifexis for years, and has been doing great with it. Each year the Vet gives her a clean bill of heath. Allivet Phy has always been the one with the lowest price.

Katherine V Verified Purchase
March 20, 2025

Works well

My dogs have been taking Trifexis for years, and I have not had any issues, other than I have to find creative ways each month to get them to take the pills. They absolutely hate them. But I'm pleased that the med is effective. So I'll stick with it...and continue to find yummy ways to entice the dogs to take them!

Eric O Verified Purchase
January 17, 2025

Good Medication for Flea and parasite Control

I have been giving this to my dog for years after being prescribed by my vet. It works and my dog shows no side effects.

Delandria B Verified Purchase
November 28, 2024

My dog has been taking this medicine since he was able, I have had no issues he is 4yrs old never had worms and I’ve never seen a flea heart worm test is always negative. He has never taken a different prescription. If possible try not to change your medication for your animal. I have a Minature Schnauzer male neutered weight is about 15-17 lbs

Genevieve A Verified Purchase
October 28, 2024

Works Great! Only flea medication that has worked as a preventative. Topical meds do not work well. If my dog gets fleas while I’ve run out will use Capstar, which works so fast!

Deborah R Verified Purchase
August 3, 2024

This product has worked on my dogs for years. None of my dogs have any allergies to it compared to another brand.

ELIZABETH B Verified Purchase
August 1, 2024

Never had an issue giving our Zo these. She takes them as a treat, with ease. Seems to like the flavor compared to simparica Trio, which we had to force feed her. she spit out every form tried to give to her. I've noted the following text for you: "Never had an issue giving our dog Zo these. She takes them as a treat with ease. She seems to like the flavor compared to Simparica Trio, which we had to force-feed her. She spat out every form we tried to give to her. She loved Heartgard chews as well, they are just too expensive. Price wise and ease of acceptance with the Trifexis, is worth it. Very good product.

Stephanie W Verified Purchase
July 27, 2024

This presentation is the best! Cooper loves the taste and it keeps the fleas away. Cooper had no side effects with this medication either. ❤

Godsflower73
June 17, 2024

Trifexis works really well, but my dog HATES the flavor with a passion. I wish Trifexis would come up with a new and improved better flavor, and we would be very happy.

Barb M
January 5, 2024

Good product that treats a lot of things at once. However, these pills need to be more palatable .I have to cut each one into 1/4's and wrap in a pill pocket to get the dog to eat them

VJB
December 1, 2023

Seems to work, but had great difficulty getting my dog to take it. I would have to describe its aroma as "chemical" and thereby not very tempting for any animal to eat. Cannot recommend this product.

Joy F
October 11, 2023

I love this product. I have been using it for years on my pets. They have no fleas or ticks. Best product on the market.

Karen P Verified Purchase
March 13, 2023

This product works ... never seen a flea on Tigi and this is also her de-wormer. Great product!

Donald o Verified Purchase
March 5, 2023

Recommended by Vet. Loretta has never had a problem with ticks or fleas

Mary L Verified Purchase
March 3, 2023

I’ve been using this medication for 9 years. My pet has had no side effects and has never had fleas, ticks, or other parasites. It’s affordable and easy to dispense.

Tiffany C
January 6, 2023

It’s a flea and tick pill all in one - beef flavored so ur dog thinks it’s a treat. And necessary protection for all dogs. Highly recommend this.

Adriana C
January 3, 2023

Works well for my dog, no fleas or ticks. My only concern is that the pill is so huge and my dislikes the taste, so she refuses to eat it. I'm not sure if it's too much for her or if the medicine makes her sick, but she always looks sickly afterwards for a few days. Sometimes she feels so sick that she vomits it up, so I am looking for a new pill.

Brian L Verified Purchase
December 30, 2022

You can't beat the price!

Robert
December 6, 2022

They work as described.

Julie P
December 4, 2022

This is an easy all in one heartwarming and flea med ths even picky pups 💕 love

Ivette S Verified Purchase
December 1, 2022

I believe this medication is best choice for my dogs

Ginny B
November 29, 2022

Excellent product, great delivery and customer service. Love Allivet!

Naomi K Verified Purchase
November 24, 2022

The dogs love them! I have had excellent experiences using this product.

Carynne B
November 17, 2022

Trifexis works great. My dog has been taking this for about a year and we haven’t seen a single flea or tick on her, and no heart worms either. I just wish it had a better flavor, so that it would be easier to give to my dog.

Heather E
November 16, 2022

Works great and even lasts a little longer than expected. I never have to worry about fleas with this product!! And as always shipping is fast and easy, right to my door!!!!

Donna B Verified Purchase
November 1, 2022

This brand is not carried by my provider and a friend highly recommended this brand for all her pets.

Ivette S Verified Purchase
October 20, 2022

This product has everything to protect our lovely pets and the price is good for the budget

Lillia G Verified Purchase
October 12, 2022

Lowest price found.

David S Verified Purchase
October 8, 2022

My dogs have never had a flea since taking this product.

Beverly D Verified Purchase
October 4, 2022

I have always had a pleasant experience dealing with Allivet.

Wan Y
October 3, 2022

Been using this product for 14 years, never had an issue

Barbara R Verified Purchase
October 3, 2022

We have gave this to our dogs sense we hade them. it works for us and them.

Leslie V
September 29, 2022

Works great and our pet loves it ❤️.

Teresa B Verified Purchase
September 25, 2022

It's good to know that you heart worm protection and flea and tick in the same pill. Once a mo

Charlotte M Verified Purchase
August 21, 2022

Been dealing with Allivet for quite awhile and highly reccomend this company.

Valerie D Verified Purchase
July 21, 2022

This works like a charm.

Suzan P Verified Purchase
June 28, 2022

Fabulous product. My dachshund swallows pill easily when it's in a small bowl of wet food (her favorite: pate). She has been taking this product for years. _ Best offer is with Allivet!

Barbara S Verified Purchase
June 28, 2022

BEEN USING THIS FOR 10 YRS AND IT WORKS GREAT and i saved money from Allivet

Karen Z Verified Purchase
June 24, 2022

This is medication is the best! You get both your fur babies heart worm and flea & tick medication all in one easy chewable tablet. I have to admit that our Jameson doesn’t care for the smell or taste but it’s nothing that a little peanut butter or cheese doesn’t take care of. I’m so glad someone finally combined both medications into one tablet.

Adriana H Verified Purchase
June 22, 2022

Great product. Does what it is supposed to do.

Patricia G Verified Purchase
June 21, 2022

Works for my dog - good price.

Jessica G Verified Purchase
June 3, 2022

Great product. My dog has NEVER had any issues.

Myrta H Verified Purchase
May 12, 2022

Easy online purchase and great customer service

Mary K Verified Purchase
April 24, 2022

My dog has no problems digesting it and it seems to be working very well.

Pat K
April 21, 2022

It works well to treat fleas but my Mini Aussie hates taking it. I had an issue with auto-ship and not receiving the product. I contacted via Live Chat and worked with Carlos. He quickly responded with sending it out again immediately. Wow, what customer service. I tried to rate his service in the survey but I could not get the info to be input. Excellent customer service from Carlos on 4/21/22 at 4:40pm

Amanda B Verified Purchase
March 31, 2022

This stuff works great...just wish it wasn't so expensive

Rosalinda S Verified Purchase
March 31, 2022

I like that I can order from home

Glenda S Verified Purchase
March 31, 2022

Trifexis is working for Zoey. It is so convenient to get it by auto-ship service. Thank you!

Deborah R Verified Purchase
March 31, 2022

I have four dogs and this stuff works well for all of them. It doesn’t cause them any discomfort compared to another medication that caused an allergic reaction which included hives to one of them.

MINH N Verified Purchase
March 31, 2022

Shopping with ease & pricing is competitive!

Adrienne d Verified Purchase
March 31, 2022

product recommended for my pet

HENRY L Verified Purchase
March 15, 2022

I love how Trifexis protects my dog.♥️

Ruby S Verified Purchase
March 8, 2022

Awesome Price. I saved over $70

Donald o Verified Purchase
February 25, 2022

This product is expensive but it works, 100%!!!

Donald N Verified Purchase
February 24, 2022

Works well for Bucster

Pam W Verified Purchase
February 24, 2022

Good service. Quick shipping.

Doris J Verified Purchase
February 24, 2022

Customer service at allivet is well and beyond excellent they kept me up to date when my vet was not responding caught a mistake they made I totally trust allivet with all my pets needs

Virginia J Verified Purchase
February 22, 2022

I Always use Allivet since they are professional, friendly, thorough, and easy! Angel did a great job and made my order so quick, smooth, and he saved me more money! Thank You!

Kathy W Verified Purchase
February 18, 2022

excellent product for my little toy poodle

Jerrie O Verified Purchase
February 17, 2022

Great company. Always prompt and very customer friendly.

Harmeet G Verified Purchase
February 14, 2022

Awesome prices and great service

Frank R Verified Purchase
February 11, 2022

Best for heart worm and fleas all in one pill.

Gerald C Verified Purchase
February 11, 2022

We called Allivet, asked them to send Willow's Trifexis, & in less than a week had her 6 month supply. We are ready to travel! Thanks Allivet!!

Cheryl h Verified Purchase
February 4, 2022

Great product, knocks out everything with one chew. I do have to wrap it on cheese to get her to eat it, nut she's a lil diva.

Monica T Verified Purchase
February 2, 2022

My blue pit has never been infested with fleas and I'm so thankful to have her on this monthly remedie.

Chin H Verified Purchase
January 26, 2022

The right one for my puppy.

Patricia J Verified Purchase
January 25, 2022

Great selection and prices!

Laura A Verified Purchase
January 17, 2022

This is a great medicine! It's all-in-one protection in a safe, easy way! Her vet recommended this medication & it's done great for her for years!

Sheila W Verified Purchase
January 17, 2022

I love allivet

Kayla N Verified Purchase
January 11, 2022

Our dog loves getting this beefy pill once a month! Very happy that it is formulated to attract their taste!

Joan C Verified Purchase
January 11, 2022

Very easy to order. Delivered quickly and check with my vet!

Mary F Verified Purchase
January 11, 2022

Trifexis is convenient and effective flea and heart worm prevention for my dog.

Cesar B Verified Purchase
January 11, 2022

using it for years and has never let me down

Lester W Verified Purchase
January 11, 2022

Just purchased for my dog. Liked the low price.

Paul V Verified Purchase
January 11, 2022

Great product with no negative side effects.

Richard H Verified Purchase
January 11, 2022

Great price and so easy to work with!

Judith L Verified Purchase
January 11, 2022

This saves a trip to the vet to pick it up

Jennifer S Verified Purchase
January 11, 2022

Have purchased Trifexis for all the dogs I have/had over the years! Very reliable, dogs gobble it up with meals!

Steve G Verified Purchase
January 11, 2022

The best all inclusive product.

Julie P Verified Purchase
January 11, 2022

All in one heart-worm and flea prevention

Katherine L Verified Purchase
January 5, 2022

My pet has been on this since she was a puppy.

Harold M Verified Purchase
January 5, 2022

Wouldn't order from anyone else love the Products and Service

Andrea S Verified Purchase
December 14, 2021

Because it works for fleas, ticks AND heart worm.

Questions & Answers