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Zylkene, 30 Capsules

By Zylkene
(110 reviews)
Veterinary Diet Item
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Zylkene, 30 Capsules

By Zylkene
$37.99
One-time purchase
$22.79 AutoShip & Save up to 40%
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Product Overview

Zylkene 30 Capsules is an all natural, non sedative supplement which reduces the signs of stress and helps restore balance and harmony in cats and dogs, with no known side effects.
Zylkene Capsules are all-natural, non-sedative supplements that reduce stress and help in the restoration of harmony and balance.
For use in cats and dogs.
Zylkene Capsules are a non-sedative, all-natural supplement that reduces stress signs without any known side effects.
Zylkene contains a natural ingredient derived from casein, which is a milk protein that is well-known to promote relaxation in newborns after breastfeeding.
Zylkene has no known side effects. However, if you notice any unusual symptoms, contact your veterinarian.
Dried hydrolyzed casein, maltodextrin, magnesium stearate
Contact your closest emergency pet hospital.
Keep out of reach of animals and children. Close tightly after use. Only intended for supplemental or intermittent feeding. Consult your veterinarian prior to administration. Follow recommended administration unless your veterinarian directs you otherwise.
30 capsules of 75 mg, 225 mg, or 450 mg strength.
Vetoquinol
You may administer Zylkene by mixing with milk, water, or other liquids (this product is water soluble) or by opening the capsule and combining with your pet's food or as a treat.
Zylkene 75mg
Dogs and Cats under 10 lbs use 1 Capsule a day
Dogs and Cats 11 to 22 lbs use 2 Capsules a day
 
Zylkene 225mg
Dogs 22 to 32 lbs use 1 Capsule a day
Dogs 33 to 65 lbs use 2 Capsules a day
 
Zylkene 450mg
Dogs 33 to 65 lbs use 1 Capsule a day
Dogs 66 to 132 lbs use 2 Capsules a day
 
Ingredients : Maltodextrin, dried hydrolysed casein, magnesium stearate

About This Product

Customer Reviews

4.8
110 reviews
5 90
4 18
3 1
2 0
1 1
Melissa
April 27, 2024

I had 3 cats on these and it did absolutely nothing for any of them! I have a cat on prozac and hemp, and anxitane with none of them working even after several months. Not sure if my cats are just immune, but don't waste your money. The expense and aggravation are not worth it.

K. W
July 7, 2022

One of my Papillons is deathly afraid of thunder and fireworks, both of which we had this past Fourth of July. Last year she was so frightened by the fireworks, she hid under the bed for 3 days, and then was excruciatingly wary of any loud sounds for many months thereafter. Started the Zylkene 4 days prior to the Fourth and noticed even on the first day she wasn't really bothered by a thunderstorm we were having. Then on the Fourth, despite multiple firecrackers being set off nearby, local fireworks displays, and yet another thunderstorm, she actually started barking at all of the different sounds rather than running and hiding from them. Although she later spent part of the night under the bed, in the morning she came right out, as if nothing had happened. A vast improvement. Am so glad I finally found something that actually works!

Jane P Verified Purchase
August 12, 2021

Two of my cats don’t get along…this medication calms them

Dawn E Verified Purchase
June 22, 2021

So glad I found this pharmacy. Prices are very reasonable.

Chris J Verified Purchase
June 10, 2021

This product is very helpful with some of the puppy mill dogs the rescue receives. Long term use allows the animals the time needed to adjust behaviors to allow them to become adoptable

Nancy G Verified Purchase
May 3, 2021

Product works.

Daniel S Verified Purchase
May 3, 2021

I saved the total of $149 dollars and the arrival was better than I have had anywhere.... Check it out folks

Nicole A Verified Purchase
May 3, 2021

This product calms down my "former" feral cat who is aggressive and marks int he house. It does not stop behavior entirely, but it does quell his aggression. I buy the 450mg and spread it on the food for all five cats.

Janet P Verified Purchase
April 26, 2021

Vet recommended

Pat T Verified Purchase
March 3, 2020

Great calming aid!

Rebecca R Verified Purchase
December 4, 2019

Good price for a quality product that reduces pet anxiety!

Carla W Verified Purchase
July 22, 2019

Zylkene calms my kitty enough to keep him from chewing his hair off! Otherwise he is a patchy mess!

Beth A Verified Purchase
May 8, 2019

My vet's crew introduced me to Zylkene a couple of years ago. I give it to my dog who has separation anxiety when it's too warm to take him with us; I've given it to my older cat who had trouble adjusting with a new kitty in the house. It works pretty well for one time uses, but does definitely improve over a course of a few days or even weeks. Zylkene mellows them both out. I like that it's a natural product and I don't have to worry about what it is doing to their little bodies. I've been able to mellow out a stray injured cat until I could get in to see the vet. As long as I have pets, I will have some Zylkene on hand.

Andrea C Verified Purchase
February 4, 2019

This is an excellent product

SHARON B Verified Purchase
January 17, 2019

Product is fine, now using with 3 cats,

Ferdie L Verified Purchase
January 14, 2019

We use this because it works.

Charles C Verified Purchase
December 17, 2018

Best price I found on the web. Other products we order from Allivet have equally good prices.

Tracy R Verified Purchase
October 23, 2018

hoping that this works to curtail my cats spraying behavior

Jackie C Verified Purchase
September 14, 2018

Works great for my dogs anxiety and separation

Jackie C Verified Purchase
September 14, 2018

works great for my dogs anxiety and crankiness

Luanne B Verified Purchase
August 12, 2018

Lower price than Pet Meds

JOHN L Verified Purchase
June 7, 2018

Noticed a marked difference in Leo's behavior.

Debra S Verified Purchase
May 31, 2018

Best Price on the web! And much better than what my Vet charges.

Lisa T Verified Purchase
May 21, 2018

Vet recommended this for my cats for our cross country move. We did a trial to make sure it worked, and my cats were so much more mellow in the car for the 30 minutes test run than they ever have been for the 2 minute ride to the vet.

Susan M Verified Purchase
February 27, 2018

Saved money

Jackie C Verified Purchase
January 8, 2018

It has helped with his anxiety and seizures. He is doing much better.

WALTER C Verified Purchase
November 6, 2017

to com my dog down

James J Verified Purchase
August 1, 2017

MY COCKAPOO "BUDDY" HAS SEPERATION ANXIETY

Susan B Verified Purchase
June 2, 2017

I have a crazy maniac cat. He is a one person cat and Zylkene has worked and performed so much better then the prescribe medication I was giving him.

Susan B Verified Purchase
February 24, 2017

I started with the Buspirone holding off giving this to see if Buspirone works. I commend the customer service area for taking the time to speak with his vet.

Donna A Verified Purchase
December 20, 2016

I bought this for Princess and it works great!!

Maria C Verified Purchase
December 1, 2016

This is the only thing that reduces my dogs anxiety. It really makes a huge difference. We give him this each and every day. One time we tried to take him off, his anxiety got really bad, and we realized how much the medicine had been helping.

Catherine Y Verified Purchase
August 26, 2016

Adopted a young Duck Tolling Retriever who had been dumped in a shelter and spent 90 days waiting for someone to notice her. She had obviously had a bad experience with the past owener who had dumped her at the shelter as a 'crazy dog'. My vet recommended this product and she has calmed down and is fitting in just fine. She is calm, loving and fitting in just fine. I hope anyone who has a dog with anxiety or is planning on a dopting a dog who has been in the shelter system will give this a try. I would not recommend this product nor would I pay the price if it were not worth every penny. It is great.

Sharon G Verified Purchase
July 6, 2016

Our aging dog as become fearful of thunder, we have found using Zylkene, takes the edge off, calms him to a state that allows us to sit and reassure him through the event. He has no drugged after effects, which makes us comfortable in our choice to give him Zylkene. I make sure to keep these well stocked in our home.

Paula G Verified Purchase
April 12, 2016

This product is great during fireworks season!! My dog is not as frightened as usual!

SHERRY H Verified Purchase
March 24, 2016

The meds are working she is less aggressive toward our other dog and just in general..

Megan D Verified Purchase
March 20, 2016

I have had one of my rescue dogs for 5 years and she was badly abused before I got her. Her fear of everything is definitely better than it used to be, but she was still having accidents when I wasn't home. Even if I had walked her and left for only 30 minutes she would have an accident. I figured it could be separation anxiety and my vet recommended we try this product before trying something stronger. She has been on it for over a month and has only had 2 accidents so I would say it's working. It is very pricy though.

Virginia P Verified Purchase
January 18, 2016

One of my cats has separation anxiety and this has helped her greatly! She no longer cries when my husband leaves the house and her constant grooming has lessened. Vet recommended two capsules once a day, but we have backed it down to 1/2 capsule in her morning food. It is just enough to relax her without making her into a zombie....which the two capsules a day did. She is a much happier and more relaxed kitty now!

Maria C Verified Purchase
December 23, 2015

Our dog gets so upset when we leave her home, even for a short time, so much so that the next day her tummy is upset and she can't eat. But since discovering Zylkene from our vet, we give her this a half hour before we go out and the next day her stomach isn't all in knots from being upset the day before. YAY!

Porta S Verified Purchase
December 22, 2015

Allivet!!! Love the zyklene! Using it was calmed my cats nerves, and she no longer pees outside of the litter box, out of stress. This stuff saved a life! I also love that it is shipped directly to my house, automatically. I don't have to worry about running out, or forgetting to buy more. Very pleased, and highly recommended! Thank you, Allivet!

Fran W Verified Purchase
October 29, 2015

This is a new, gentle calming homeopathic product which my vet recommended. My 2-year old Parsons Russell terrier is more even-keeled everyday without being 'a zombie. And he's still a great athlete. Allivet's prices are, by far, the cheapest for the exact same product.

Gonul Y Verified Purchase
October 4, 2015

Great product and it really works!

Debra T Verified Purchase
September 25, 2015

Zylkene has been very effective in calming my anxious dog

Patricia A Verified Purchase
September 25, 2015

It helps anxiety in two of my dogs.

Barbara K Verified Purchase
September 7, 2015

My new friend had terrible separation anxiety. A vet at the shelter he came from, prescribed Zylkene and we've had great success with it. He still doesn't like when I leave but he's much less noisy about it. I see no loss of energy to walk and play.

Gail M Verified Purchase
September 7, 2015

Best price online for Zylkene 450. Will buy again from this store!

Seleen Z Verified Purchase
September 7, 2015

Great price and my product arrives promptly.

Laura L Verified Purchase
September 6, 2015

I have three 6 year old cats. All siblings. One of the females shows her stress by attacking her siblings - and occasionally me. My vet recommended an in-home visit from a vet behaviorist. The vet behaviorist recommended using Zylkene to decrease her anxiety (I was already using Natural Pet Anxiety and Stress in their water and Comfort Zone cat pheromones). The vet said that if the Zylkene didn't work, that I should consider euthanasia. Zylkene has kept my kitty family together. I tried to wean her off of it (all of this gets pretty expensive), but her hiding/aggression behavior returned when the med wore off. I restarted it, and things are back to our new normal.

Christine S Verified Purchase
September 4, 2015

great price! helps my dog with anxiety.

Kia P Verified Purchase
August 19, 2015

My 8 yr old pug was diagnosed with OCD. she was put on Prozac. this helped but still showed symptons. My vet then put her on Zylkene and this made a big difference. However the vets price made it almost unaffordable for a retiree. Allivets price makes me able to continue using the product.

Lynn R Verified Purchase
August 11, 2015

I bought Zylkene upon the recommendation of a dog trainer who has been helping me with my Yorkie who has separation anxiety. I was doubtful, but I believe this medication has made a noticeable difference in his anxiety. He is calmer and less whiny. I give him one capsule in the morning with some food and one with dinner. I open the capsule and mix it up with the food and he doesn't notice it. But I notice the change! I am going to order more this morning and hope it comes in larger quanitities.

Karen W Verified Purchase
July 27, 2015

All natural calming agent that really works for thunder, licking at feet, etc. I got it at my vet at a much higher price. It does not require a prescription.

Judy H Verified Purchase
July 18, 2015

it helped my dog deal with fireworks during the holiday

Gwen B Verified Purchase
July 8, 2015

I bought Zylkene from Allivet to calm anxiety in my dog because the price for the exact same brand of supplement and strength and number of pills was the best price found online.

Kevin S Verified Purchase
June 30, 2015

Best Price found on this item

Laila S Verified Purchase
June 27, 2015

I was one step away from having to put my cat on kitty prozac for anxiety issues but thankfully we found zylkene and she has been doing great! I give it to her once a day (mixed in water and squirted in her mouth) and it has not altered her personality at all but has helped her not have anxiety attacks.

Lori L Verified Purchase
June 25, 2015

This was prescribed by my vet for my little Chihuahua who has pretty bad anxiety. I wanted my other dog to take it also and it is a little pricey, but cheaper on this site. Shipped quickly and arrived as stated. It doesn't completely take away their anxiety when I leave, but I am convinced it does 'take the edge off' so to speak. They both seem a little calmer since on this product. I will keep using it as long as I can afford it.

Deb S Verified Purchase
June 13, 2015

I bought this for my dog that has anxiety. This time I bought more because now that it is getting closer to the 4tth of July both of my dogs get nervous with the fireworks, and this med really helps calm them down. I really like this product because it is all natural and is not a sedative.

Laura K Verified Purchase
June 3, 2015

Excellent product!!! A lot less expensive on this site.

Megan E Verified Purchase
May 26, 2015

Purchasing was easy and the website also easy to navigate

Elizabeth G Verified Purchase
May 22, 2015

We have finally found something that safely, really eases our boys anxiety. We don't have to use it all the time, but for situational anxiety--and it makes a huge difference. I highly recommend.

Kay M Verified Purchase
May 21, 2015

Recommended to alleviate over grooming -- has worked like a miracle drug.

Sharon V Verified Purchase
May 19, 2015

The price is much lower than at the vet. Thanks.

Diane M Verified Purchase
May 5, 2015

My new cat comes from a shelter where he had little experience with people and is very nervous. I bought zylkene to help calm him while he adjusts.

April B Verified Purchase
April 29, 2015

Allivet had the best price I could find on 450mg of Zylkene. This is a very expensive medication so every dollar I save really helps. Shipping took a little while, so don't wait until you're out to purchase, but other than that, I'm very happy with my purchase.

Kristi H Verified Purchase
March 30, 2015

I have a dog who is afraid of her own tail. I rescued her almost a year ago and she seemed to be getting worse everyday. I am not sure her extent of abuse before I got her but I know she is happier in my home. My vet recommended Zylkene 450mg at 2 a day. They have helped calm her down some. She still has a lot of anxiety but she is definately better than she was. She doesn't pace as bad and let's some people pet her at times.

Jay L Verified Purchase
March 26, 2015

Matchka has a behavioral problem with anxiety and possible BiPolar events where one minute he's happy and purring and the next growley and does not want to be touched. since staring the Zylkene, he is much better and less stressed! Plus with no side effects, this is a very good product one that can be given for a lifetime....

Crystal N Verified Purchase
March 22, 2015

Seems to help my chihuahua who has very bad anxiety after being abused. This is used in conjunction with anti-anxiety prescription medications.

Suzanne T Verified Purchase
March 14, 2015

I ordered from Allivet as I was searching for a less expensive source. The website was easy to navigate and my order was delivered promptly exactly as ordered. I was extremely pleased with my experience and plan to re-order from Allivet.

Diana H Verified Purchase
March 8, 2015

Veterinarian suggested this for my older dog who is having aggressive dementia (he is becoming more and more stubborn and crotchety). It does help him to keep his cool, Zylkene works. It is not a miracle but it takes the edge off for him.

Kelly C Verified Purchase
March 3, 2015

Great price! Could not find a better price anywhere and this medicine is a life saver for our dog with separation anxiety! It has taken the 'edge' off of her.

Kristina B Verified Purchase
March 3, 2015

We bought this product to help a dog with anxiety, we are hoping it works.

Janet J Verified Purchase
February 24, 2015

My dog began exhibiting anxiety and after a clean bill of health from the vet, she recommended Zylkene. It does appear to be helping him feel more comfortable without any sedating effect. Allivet's price was considerably lower than at my vet making it more affordable for me to continue to treat him.

Brenda S Verified Purchase
February 23, 2015

Found it easier to just give my dog the capsule in a pill treat as he wasn't finishing the food I was opening the capsule in to. So, it took a few more days to see any help. He had been on Valium and I am trying this instead. Seems to be pretty close to the same results but feel better about this medication than the Valium option. I'm still not totally sure about it as he has had some evening trembling issues still. Although, I think they are lessening in frequency and length.

Tareyece S Verified Purchase
February 16, 2015

My Havanese is a rescue....and when evaluated by a pet therapist, they determined he had anxiety issues. Instead of prescribing a human medication, she recommend Zylkene. It has made a huge difference for him. I can't reccomend it enough........Allivet was amazing. They had it in stock, sent it quickly and had a monthly renewal to make things easier. I am a customer for life.

Jacquie A Verified Purchase
February 12, 2015

Zylkene seems to be helping our troubled, special needs dog in ways that the other medication and supplement he is on aren't. He seems alert, but less reactive to negative situations.

Cassandra G Verified Purchase
February 11, 2015

Of all the natural anti-anxiety options I've tried for my reactive border collie mix, this seems to work the best. It does not make her sleepy, but does seem to take the edge off so that she can hear me. Sometimes I halve the dosage to make them last a little longer, and I still notice a benefit, but the full dose works best, of course. Allivet had the best price and i was very pleased they make it more affordable.

Hope H Verified Purchase
February 8, 2015

What a difference a daily dose makes to my anxious cat! He used to howl in the middle of the night and after the vet diagnosed 'anxiety disorder' instead of physical problems, he recommended Zylkene. I open one capsule in my cat's morning wet food and he's fine for 24 hours! Great product!

Buckydonkey Verified Purchase
February 8, 2015

My Vet found it as alternative to xanax for my dog who is in renal failure. He's afraid of subcutaneous injections & can't wait to try this to help w/his anxiety as he's fading. It's horrible knowing he's afraid of the 'treatment' as well as any time I leave (I can't anymore!). From what I've read this IS the product to help! Wish us luck.

Megan S Verified Purchase
January 30, 2015

One of our 10-year-old cats started inappropriately eliminating outside of the litterbox. A check-up at our vet told us she had a clean bill of health, but was likely dealing with some anxiety issues, which made sense because she's always been a bit of an anxious kitty. Our vet recommended that we try Zylkene first, before moving on to more serious antidepressants and sent us home with two week's worth of pills to the tune of $30. We open the capsule and mix it with a little bit of wet food and she eats it no problem. After two days we saw a huge change in our kitty's demeanor. She has become more confident, outgoing and playful and less fearful. The inappropriate elimination has stopped completely. When I called our vet to refill the prescription, our vet was out of stock and I was told it would be a few weeks until they'd be able to fill our request. With Allivet, not only was Zylkene considerably more affordable, but shipping was fast and I can sign up for auto-ship of our reorder so I don't have to worry about running out. Highly recommend!

Julie B Verified Purchase
January 22, 2015

This makes such a difference for my cat.

Candi g Verified Purchase
January 22, 2015

My 10 year old Gordon Setter has become increasingly neurotic and fearful of everything. My vet suggested this product. It has made a huge improvement in her quality of life. She no longer hides in the bedroom and is willing to join the rest of the family. She has settled down and no longer paces at night. She has even started sleeping in bed , with me and the other girls, again. It only took a few days to notice an improvement in her attitude.

Trisha M Verified Purchase
January 21, 2015

My neutered cat has seperation anxiety issues and started spraying around our house everytime we went out of town for a few days or more. After dealing with this issue for over a year, I finally took him to the vet to get help. They put him on Zylkene 75mg and it has worked out quite well. Even the base in our living room used to scare him when it boomed during movies, he doesn't seem to be as skittish towards that either now. Still the same sweet cat, just a little more calm and our house doesn't stink anymore!

Diane K Verified Purchase
January 20, 2015

This product has done wonders for my 16 year old dog who was exhibiting signs of dementia. My vet recommended Zylkene and I have been giving it to her for months, and her symptoms of confusion and disorientation have disappeared. It is difficult to get this product sometimes but Allivet got it to me immediately and at the most competitive price I have seen. Great product and great delivery and service from Allivet.

Nicole N Verified Purchase
January 20, 2015

I rescued a sweet pup with terrible anxiety and she needs this medication twice a day.

Laraine K Verified Purchase
January 18, 2015

Lost our two 15 year old dogs within a few months of each other, leaving their 13 year old sister anxiety ridden - scared and shaking all the time. Zylkene has made a world of difference - totally calms her down. Only took a couple of days to see a major change.

Kathlyn S Verified Purchase
January 15, 2015

My vet prescribed this for my cat to handle the cat's aggressive behavior [it has attacked me twice, fairly severely]. The cat has been on Zylkene for over two months, and so far, no more attacks. At the vet's office, this product cost in excess of $40 for 30 pills, plus tax. In searching the internet, Allivet has the most competitive price that I could find, less than half the cost of the vet. It is easy to order here, and the product comes quickly. I have ordered twice, with no problems and would recommend the product [if your vet agrees] plus the ordering experience here has been very positive.

Sharon L Verified Purchase
January 14, 2015

Purchased for multi-cat household with behavior problems. The supplement seems to calm several of the cats reducing stress in the home. I use 1 450mg capsule sprinkled among 6 cat's canned food bowls once a day.

Susan W Verified Purchase
January 9, 2015

Extremely nervous and high-strung Airedale who has become destructive when 'wigging-out'. Has destroyed crates and doors and torn up her foot pads. Zylkene seems to be helping. Much better than the Prozac we tried or Phenobarbitol alone.

John C Verified Purchase
January 8, 2015

Accurate order fulfillment, quick delivery.

Ana L Verified Purchase
January 1, 2015

It's not miraculous. But when we stopped it we noticed more anxiety in our dog about a week later. Our cocker spaniel does not like people close by, strangers walking by, or walking out of their homes on our street. On these, we can get him to sit, and eat a treat while watching these triggers and not got overly worked up. It helps make him susceptible to training.

Edward T Verified Purchase
December 30, 2014

the medication was suggested by my vet to calm my poor snauzer pup down a little. She has been diagnosed with cushings disease and the vet believed it would help her. It seems to have done the trick or at least helped out in the long run. However; Allivet has been a disappointment in their delivery process. After requesting and paying for the med some several weeks ago, i am down to one pill for my pup and still waiting for the meds to be delivered some 10 days post payment.

Lisa E Verified Purchase
December 17, 2014

Purchased this for my anxious dog. Allivet was awesome with communication and shipping. And they had the best price I could find online.

Paula H Verified Purchase
December 15, 2014

This med, recommended by my vet, has allowed my very fearful rescue dog to become an interactive member of our family. I like that it is a natural product and not a heavy pharmaceutical like most of the anti-anxiety drugs prescribed for dogs. At Allivet.com the med was about 40% cheaper than at my vet's office. Wished I'd found your website earlier!

Theresa m Verified Purchase
December 9, 2014

Easy ordering and great price and they have auto refill.

Peg H Verified Purchase
December 5, 2014

Trying to help my dog not be afraid of the world...

Deborah R Verified Purchase
November 30, 2014

Very pleased with order. Product arrived in a few days. When I have ordered from other sites it has taken over a week. Price is great. I will be ordering again soon! Happy happy!

Michele B Verified Purchase
November 22, 2014

One of my 3 cats has a problem with inappropropriate urination and some anxiety. My Vet did not find any health issues, so they prescribed an anti-depressant for her which seemed to help. However, I wanted an alternative treatment to medication. Zyklene has been working well for her.

Jared N Verified Purchase
November 18, 2014

Our behaviorist recommended this product to help alleviate anxiety with our Boston Terrier. So far, he has started engaging more with the family and spending less time under the bed!

Ann S Verified Purchase
November 5, 2014

My vet suggested this product to calm my anxious cat. She seems much more relaxed after using it for 3 weeks. Your price is excellent compared to the vet's!

Questions & Answers