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Proin Rx

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Product Overview

How To Use

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Questions & Answers

Product Description

For dogs experiencing incontinence issues, Proin can provide relief. This FDA-approved medication comes in a chewable tablet containing phenylpropanolamine to aid in the treatment and management of urinary incontinence in dogs. It works as an adrenergic agent to help dogs with leakage of urine by tightening the bladder sphincter muscle.

 *This item can't be shipped to AR, GA, HI, IA, LA, OR or WV.

What is Proin?

Proin is a chewable tablet used for the management and treatment of urinary incontinence in dogs. Proin is manufactured by PRB Pharmacal, Inc and contains phenylpropanolamine. It is available in all states except Arkansas, Georgia, Hawaii, Iowa, Louisiana, Oregon or West Virginia, where it is classified as a controlled substance.

Who is Proin for?

Proin is intended for use in dogs with leakage of urine or urinary incontinence.

Why use Proin?

  • Chewable Proin tablets are intended to treat dogs with urinary incontinence.
  • Proin works by maintaining bloodstream levels of phenylpropanolamine.
  • Can aid in the reduction of symptoms associated with increased phenylpropanolamine levels such as:
    • Heart rate changes
    • Increase in blood pressure
    • Hyperexcitability
    • Decrease in appetite
  • How does Proin work?

    Proin works to tighten the urethral sphincter muscle responsible for the prevention of urine leaking. Its active ingredient is phenylpropanolamine which works as an adrenergic agent.


    PRN Pharmacal, Inc.

    Active ingredient(s):

    Phenylpropanolamine Hydrochloride

    How is Proin sold?

    Proin Chewable tablets are available in 25mg, 50mg, and 75mg strengths as single tablets or 60 or 180 count bottles.

    What are the side effects of Proin?

    Phenylpropanolamine is known to cause a response known as "fight or flight." This may lead to side effects including:
    • High blood pressure
    • Increase in heart rate
    • Restlessness
    • There may also be a reduction or loss of appetite which may have long term issues.

    What special precautions are there?

    Dogs exhibiting hypersensitivity to Anipryl should not take the drug. Keep out of reach of children and pets.

    What to do if overdose?

    In case of Proin overdose contact your veterinarian or veterinary emergency room. Symptoms of overdose may include increased thirst, urination and hunger, hyperactivity, personality change, and reduced heat tolerance.

    How can I store Proin?

    Store in a dry and cool environment. 68° to 77°F (20° to 25°C)

    Helpful Tips:

    The main cause of urinary incontinence in dogs is infection of the bladder which leads to an increased urge to urinate. Bladder infections in dogs means their bladders are only emptied partially during urination. Consequently, urine is smelly because it is only partially emptied.

    Blood may appear in the urine from cancer, calculi or tumors which can cause infection.

    Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.


    Use as directed by your veterinarian. The usual dose of Proin for dogs is 0.4-0.8mg/pound every 12 hours.

    Main Ingredients

    Active Ingredient : Phenylpropanolamine Hydrochloride

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    Customer Submitted Questions

    My dog is on 2 Proins per day and still wets the bed. Can this be increased and what is the danger.

    1 Answer

    My dog has appetite suppression on Proin 25mg at 2x/day. What can be done?

    1 Answer
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