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Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm Rx
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10194-1
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Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm Rx
Veterinary Diet Item
$384.59
$344.59
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Availability:
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Usually shipped in 1-3 business days.* Learn more
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$30 max savings.
Product Overview
Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste is the first treatment approved by the FDA for equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. EPM is a serious neurologic disease that can lead to muscle loss, ataxia, and incoordination if untreated. The active ingredient, ponazuril, is a triazine-class antiprotozoal that crosses the blood-brain barrier to kill parasites in the central nervous system and prevents further neurologic damage. The easy-to-use oral paste comes in a calibrated syringe for accurate dosing and features a loading-dose and maintenance protocol that allows for rapid therapeutic levels. When used as directed, Marquis provides safe and effective parasite clearance in four weeks.
For use in horses.
• For treatment approved by the FDA of EPM in horses
• Ponazuril crosses the blood-brain barrier to act directly on CNS parasites
• Convenient oral paste delivery, with calibrated dosing syringe for accuracy
• Proven efficacy in field studies and clinical trials
• Safe when used as directed
Marquis contains ponazuril, a triazine-class antiprotozoal that targets the merozoite stages of Sarcocystis neurona. The compound interferes with protozoal metabolic pathways leading to parasite death. Because it crosses the blood-brain barrier, it can act within the central nervous system to reduce further damage.
Possible Side Effects :
• Loose feces (diarrhea) have been reported.
• Mild colic, inappetence, hives, or blisters on lips/muzzle in some horses. US-EQU-0397-2025
• Neurologic signs may temporarily worsen early in treatment before improving.
• In toxicity studies: loose feces, weight loss, occasional histopathologic changes in the uterine epithelium edema at high multiples.
15% w/w ponazuril
Contact your closest emergency pet hospital.
Warnings:
• Administer only to horses.
• The safety in pregnant, lactating mares or breeding horses is unknown.
• Neurologic signs (e.g. ataxia) may transiently worsen early during therapy, typically resolving over time.
• Distinguish EPM from other neurologic, orthopedic, or systemic causes before treatment.
US-EQU-0397-2025
• At the end of the prescribed treatment period, partially used syringes should be discarded.
Caution/Precautions:
• Horses may experience loose stools, mild colic, or inappetence, oral ulcers or hives during treatment.
• Neurologic signs may temporarily intensify as parasites die off; monitor closely and contact a veterinarian if symptoms worsen significantly.
• Use only under veterinary supervision.
• Do not administer to horses with known hypersensitivity to ponazuril or other triazine compounds.
• The safety of concurrent use with other antiparasitic or neurologic medications has not been evaluated.
Sold as individual 127 gram tube
Boehringer Ingelheim
Dosage Instructions/Directions:
• On Day 1, a loading dose of 15 mg/kg (6.8 mg/lb) (three times the maintenance dose) is recommended to quickly reach effective concentrations.
• After day 1, administer orally at a dose of 5 mg/kg body weight (2.27 mg/lb) once daily for 28 days.
• Each full syringe treats a 1,200 lb (545 kg) horse at the maintenance dose.
• Use the calibrated weight-markings on the syringe plunger to ensure accurate dosing.
• Make sure the horse’s mouth is free of feed before administration.
• Insert the syringe tip into the mouth at the interdental space and deposit the paste on the back of the tongue.
• Raise the horse’s head briefly to ensure swallowing.
• Complete the full 28-day course unless otherwise directed by a veterinarian.
Active Ingredients : Ponazuril (15% w/w) per gram of oral paste.
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Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm Description
Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste is the first treatment approved by the FDA for equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. EPM is a serious neurologic disease that can lead to muscle loss, ataxia, and incoordination if untreated. The active ingredient, ponazuril, is a triazine-class antiprotozoal that crosses the blood-brain barrier to kill parasites in the central nervous system and prevents further neurologic damage. The easy-to-use oral paste comes in a calibrated syringe for accurate dosing and features a loading-dose and maintenance protocol that allows for rapid therapeutic levels. When used as directed, Marquis provides safe and effective parasite clearance in four weeks.
Which animals/pets is Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm for?
For use in horses.
Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm uses
• For treatment approved by the FDA of EPM in horses
• Ponazuril crosses the blood-brain barrier to act directly on CNS parasites
• Convenient oral paste delivery, with calibrated dosing syringe for accuracy
• Proven efficacy in field studies and clinical trials
• Safe when used as directed
What does Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm do?
Marquis contains ponazuril, a triazine-class antiprotozoal that targets the merozoite stages of Sarcocystis neurona. The compound interferes with protozoal metabolic pathways leading to parasite death. Because it crosses the blood-brain barrier, it can act within the central nervous system to reduce further damage.
Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm side effects
Possible Side Effects :
• Loose feces (diarrhea) have been reported.
• Mild colic, inappetence, hives, or blisters on lips/muzzle in some horses. US-EQU-0397-2025
• Neurologic signs may temporarily worsen early in treatment before improving.
• In toxicity studies: loose feces, weight loss, occasional histopathologic changes in the uterine epithelium edema at high multiples.
Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm ingredients
15% w/w ponazuril
Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm overdose: What to do?
Contact your closest emergency pet hospital.
What to know before using Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm
Warnings:
• Administer only to horses.
• The safety in pregnant, lactating mares or breeding horses is unknown.
• Neurologic signs (e.g. ataxia) may transiently worsen early during therapy, typically resolving over time.
• Distinguish EPM from other neurologic, orthopedic, or systemic causes before treatment.
US-EQU-0397-2025
• At the end of the prescribed treatment period, partially used syringes should be discarded.
Caution/Precautions:
• Horses may experience loose stools, mild colic, or inappetence, oral ulcers or hives during treatment.
• Neurologic signs may temporarily intensify as parasites die off; monitor closely and contact a veterinarian if symptoms worsen significantly.
• Use only under veterinary supervision.
• Do not administer to horses with known hypersensitivity to ponazuril or other triazine compounds.
• The safety of concurrent use with other antiparasitic or neurologic medications has not been evaluated.
How is Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm sold?
Sold as individual 127 gram tube
Manufacturer
Boehringer Ingelheim
Overview
Dosage Instructions/Directions:
• On Day 1, a loading dose of 15 mg/kg (6.8 mg/lb) (three times the maintenance dose) is recommended to quickly reach effective concentrations.
• After day 1, administer orally at a dose of 5 mg/kg body weight (2.27 mg/lb) once daily for 28 days.
• Each full syringe treats a 1,200 lb (545 kg) horse at the maintenance dose.
• Use the calibrated weight-markings on the syringe plunger to ensure accurate dosing.
• Make sure the horse’s mouth is free of feed before administration.
• Insert the syringe tip into the mouth at the interdental space and deposit the paste on the back of the tongue.
• Raise the horse’s head briefly to ensure swallowing.
• Complete the full 28-day course unless otherwise directed by a veterinarian.
Main Ingredients
Active Ingredients : Ponazuril (15% w/w) per gram of oral paste.
Reviews
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