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Simparica Trio Chewable Tablets for Dogs Rx
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Simparica Trio Chewable Tablets for Dogs Rx
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Product Overview
One Chew, Triple Protection
Simparica Trio is the first FDA-approved preventative of its kind and offers protection against fleas, ticks, and heartworms in a single monthly chew. Talk to your vet about Simparica Trio and have peace of mind knowing it’s backed by a 100% satisfaction guarantee.
Simparica Trio is the #1 vet-prescribed combo preventative. 1 Once monthly liver-flavored chew provides dogs all-in-one protection against heartworm disease, ticks, fleas, flea tapeworms, roundworms, and hookworms. It’s approved for puppies as young as eight weeks old and weighing at least 2.8 pounds. Simparica Trio kills fleas before they can lay eggs. In studies, it starts killing fleas within 4 hours with100% effectiveness in 8 hours. It was the first combination preventative FDA-approved to kill six types of ticks including the deer tick that may carry Lyme infections. It can be given with or without food and is loved by dogs with a study showing 9 out of 10 dogs voluntarily consumed.2 Over 15 million dogs have been protected by Simparica Trio.3 Ask your vet if Simparica Trio is right for your dog or puppy. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn’t providing sufficient protection, please call Zoetis’ medical support team to discuss the satisfaction guarantee at 1-888-ZOETIS1. Enrolling in auto ship provides savings, convenience, and the peace of mind that your dog never misses a dose. Simparica Trio is eligible for Zoetis Petcare Rewards Program. Sign up for free to earn points on every dollar spent on eligible purchases that can be redeemed for services at your vet. Learn more by visiting ZoetisPetcare.com/Rewards.
† As a direct result of killing deer ticks.
References: 1. Data on file. Kynetec PetTrak US FTH National, 2025. 2. Study A161C-US-15-634. Data on file. Zoetis Inc. 3. Simparica Trio - 15M Dogs and Counting, PetTrak Kynetec Veterinary Channel Review Q4, 2024.
Dogs and Puppies (8 weeks of age and older and weighing 2.8 lbs or more). All dogs should take some form of flea, tick, and heartworm control, whether they spend a lot of time outdoors or not. Fleas and ticks can come in on your clothing or on visiting pets. Indoor dogs can be bitten by a mosquito carrying heartworms that has made its way into your home.
• Don’t Just Protect, Triple Protect: Simparica Trio is a monthly chew that protects against three categories of parasites including heartworms, ticks & fleas, and intestinal worms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds.
• Heartworm Protection: One dose provided 100% protection against heartworm disease in studies to support FDA-approval.
• Kills 6 Types of Ticks & FDA- Approved to Prevent Lyme Infections†: The first combo preventative FDA approved to kill six types of ticks including the Gulf Coast Tick, Deer Tick, American Dog Tick, Lone Star Tick, Brown Dog Tick, and Asian Longhorned Tick.
• Kills Fleas & Intestinal Worms: Prevents flea infestations because it kills fleas before they lay eggs. Prevents tapeworms because it kills fleas. Treats and controls roundworms and hookworms.
• Satisfaction Guaranteed: Simparica Trio comes with a 100% satisfaction guarantee on prevention and is administered once a month, with or without food.
Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in arthropods. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
Sarolaner, one of the ingredients, is a member of the isoxazoline class. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurological disorders. Some possible side effects of taking Simparica Trio may include : vomiting, diarrhea, lethargy, anorexia, polyria, hyperactivity or polydypsia.
Sarolaner, one of the ingredients is a member of the isoxazoline class. This class has been associated with neurological adverse reactions such as tremors, lack of coordination, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurological disorders.
The most common side effects of taking Simparica Trio are diarrhea and vomiting. Less common side effects include:
- Lethargy
- Anorexia
- Ear infection
- Itching
- Excess urination
- Hyperactivity
- Increased water drinking
There are no known contraindications for the use of Simparica Trio.
Sarolaner, Moxidectin, Pyrantel
Contact your nearest emergency animal hospital.
Not for human use. Keep away from children and animals. The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs. Prior to administration of SIMPARICA TRIO dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. SIMPARICA TRIO is not effective against adult D. immitis.
Sold as 1 Month, 3 Month, 6 Month or 12 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs
Zoetis
Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30 AM - 5:30 PM EST and will be on call Saturday 12:00 PM - 4:00 PM EST for consultation.
Speak with your veterinarian about the recommended heartworm testing before using Simparica as heartworm infection prevention program for your pet.
If your dog has fleas or ticks, talk to your veterinarian about other control measures you a can take, such as thoroughly cleaning your pet’s bedding and vacuuming carpeted areas, paying close attention to the area along the walls. In addition, discuss what type of flea and tick pills to use on any other pets in your home, since all pets will need to be treated to avoid an infestation. Ask your veterinarian to go over the flea life cycle and how it can influence the effectiveness of monthly flea control products.
In addition, talk to your veterinarian about any other supplements or medication your pet is taking, and if they have had reactions to previous supplements and medications.
Dosage and Administration :
The recommended minimum dosage is 1.2 mg/kg (0.54 g/lb) sarolaner, 24 µg/kg (0.011 mg/lb) moxidectin, and 5 mg/kg (2.27 mg/lb) pyrantel (as pyrantel pamoate).
SIMPARICA TRIO™ is given orally on a monthly basis. SIMPARICA TRIO™ needs to be administered every 4 weeks in case of exposure to Amblyomma maculatum, Dermacentor variabilis, and Rhipicephalus sanguineus. In case of tick infestation, accurate tick identification is recommended prior to administering the product.
Body Weight / Sarolaner per Tablet (mg) / Moxidectin per Tablet (mg) / Pyrantel per Tablet (mg) / Number of Tablets Administered
2.8 to 5.5 lbs / 3.0 / 0.06 / 12.5 / 1
5.5 to 11 lbs / 6.0 / 0.12 / 25 / 1
11-22 lbs / 12 / 0.24 / 50 / 1
22-44 lbs / 24 / 0.48 / 100 / 1
44-88 lbs / 48 / 0.96 / 200 / 1
88-132 lbs / 72 / 1.44 / 300 / 1
SIMPARICA TRIO can be offered to the dog with or without food.
Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a monthly dose is missed, give immediately and resume monthly dosing.
Active Ingredients : Sarolaner, Moxidectin, Pyrantel
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Simparica Trio Chewable Tablets for Dogs Description
Simparica Trio is the #1 vet-prescribed combo preventative. 1 Once monthly liver-flavored chew provides dogs all-in-one protection against heartworm disease, ticks, fleas, flea tapeworms, roundworms, and hookworms. It’s approved for puppies as young as eight weeks old and weighing at least 2.8 pounds. Simparica Trio kills fleas before they can lay eggs. In studies, it starts killing fleas within 4 hours with100% effectiveness in 8 hours. It was the first combination preventative FDA-approved to kill six types of ticks including the deer tick that may carry Lyme infections. It can be given with or without food and is loved by dogs with a study showing 9 out of 10 dogs voluntarily consumed.2 Over 15 million dogs have been protected by Simparica Trio.3 Ask your vet if Simparica Trio is right for your dog or puppy. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn’t providing sufficient protection, please call Zoetis’ medical support team to discuss the satisfaction guarantee at 1-888-ZOETIS1. Enrolling in auto ship provides savings, convenience, and the peace of mind that your dog never misses a dose. Simparica Trio is eligible for Zoetis Petcare Rewards Program. Sign up for free to earn points on every dollar spent on eligible purchases that can be redeemed for services at your vet. Learn more by visiting ZoetisPetcare.com/Rewards.
† As a direct result of killing deer ticks.
References: 1. Data on file. Kynetec PetTrak US FTH National, 2025. 2. Study A161C-US-15-634. Data on file. Zoetis Inc. 3. Simparica Trio - 15M Dogs and Counting, PetTrak Kynetec Veterinary Channel Review Q4, 2024.
Which animals/pets is Simparica Trio Chewable Tablets for Dogs for?
Dogs and Puppies (8 weeks of age and older and weighing 2.8 lbs or more). All dogs should take some form of flea, tick, and heartworm control, whether they spend a lot of time outdoors or not. Fleas and ticks can come in on your clothing or on visiting pets. Indoor dogs can be bitten by a mosquito carrying heartworms that has made its way into your home.
Simparica Trio Chewable Tablets for Dogs uses
• Don’t Just Protect, Triple Protect: Simparica Trio is a monthly chew that protects against three categories of parasites including heartworms, ticks & fleas, and intestinal worms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds.
• Heartworm Protection: One dose provided 100% protection against heartworm disease in studies to support FDA-approval.
• Kills 6 Types of Ticks & FDA- Approved to Prevent Lyme Infections†: The first combo preventative FDA approved to kill six types of ticks including the Gulf Coast Tick, Deer Tick, American Dog Tick, Lone Star Tick, Brown Dog Tick, and Asian Longhorned Tick.
• Kills Fleas & Intestinal Worms: Prevents flea infestations because it kills fleas before they lay eggs. Prevents tapeworms because it kills fleas. Treats and controls roundworms and hookworms.
• Satisfaction Guaranteed: Simparica Trio comes with a 100% satisfaction guarantee on prevention and is administered once a month, with or without food.
What does Simparica Trio Chewable Tablets for Dogs do?
Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in arthropods. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
Simparica Trio Chewable Tablets for Dogs side effects
Sarolaner, one of the ingredients, is a member of the isoxazoline class. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurological disorders. Some possible side effects of taking Simparica Trio may include : vomiting, diarrhea, lethargy, anorexia, polyria, hyperactivity or polydypsia.
Sarolaner, one of the ingredients is a member of the isoxazoline class. This class has been associated with neurological adverse reactions such as tremors, lack of coordination, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurological disorders.
The most common side effects of taking Simparica Trio are diarrhea and vomiting. Less common side effects include:
- Lethargy
- Anorexia
- Ear infection
- Itching
- Excess urination
- Hyperactivity
- Increased water drinking
There are no known contraindications for the use of Simparica Trio.
Simparica Trio Chewable Tablets for Dogs ingredients
Sarolaner, Moxidectin, Pyrantel
Simparica Trio Chewable Tablets for Dogs overdose: What to do?
Contact your nearest emergency animal hospital.
What to know before using Simparica Trio Chewable Tablets for Dogs
Not for human use. Keep away from children and animals. The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs. Prior to administration of SIMPARICA TRIO dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. SIMPARICA TRIO is not effective against adult D. immitis.
How is Simparica Trio Chewable Tablets for Dogs sold?
Sold as 1 Month, 3 Month, 6 Month or 12 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs
Manufacturer
Zoetis
Tips for using Simparica Trio Chewable Tablets for Dogs
Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30 AM - 5:30 PM EST and will be on call Saturday 12:00 PM - 4:00 PM EST for consultation.
Speak with your veterinarian about the recommended heartworm testing before using Simparica as heartworm infection prevention program for your pet.
If your dog has fleas or ticks, talk to your veterinarian about other control measures you a can take, such as thoroughly cleaning your pet’s bedding and vacuuming carpeted areas, paying close attention to the area along the walls. In addition, discuss what type of flea and tick pills to use on any other pets in your home, since all pets will need to be treated to avoid an infestation. Ask your veterinarian to go over the flea life cycle and how it can influence the effectiveness of monthly flea control products.
In addition, talk to your veterinarian about any other supplements or medication your pet is taking, and if they have had reactions to previous supplements and medications.
Overview
Dosage and Administration :
The recommended minimum dosage is 1.2 mg/kg (0.54 g/lb) sarolaner, 24 µg/kg (0.011 mg/lb) moxidectin, and 5 mg/kg (2.27 mg/lb) pyrantel (as pyrantel pamoate).
SIMPARICA TRIO™ is given orally on a monthly basis. SIMPARICA TRIO™ needs to be administered every 4 weeks in case of exposure to Amblyomma maculatum, Dermacentor variabilis, and Rhipicephalus sanguineus. In case of tick infestation, accurate tick identification is recommended prior to administering the product.
Body Weight / Sarolaner per Tablet (mg) / Moxidectin per Tablet (mg) / Pyrantel per Tablet (mg) / Number of Tablets Administered
2.8 to 5.5 lbs / 3.0 / 0.06 / 12.5 / 1
5.5 to 11 lbs / 6.0 / 0.12 / 25 / 1
11-22 lbs / 12 / 0.24 / 50 / 1
22-44 lbs / 24 / 0.48 / 100 / 1
44-88 lbs / 48 / 0.96 / 200 / 1
88-132 lbs / 72 / 1.44 / 300 / 1
SIMPARICA TRIO can be offered to the dog with or without food.
Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a monthly dose is missed, give immediately and resume monthly dosing.
Main Ingredients
Active Ingredients : Sarolaner, Moxidectin, Pyrantel
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