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Simparica Chewable Tablets for Dogs Rx

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Product Overview

How To Use

What’s in it?



Questions & Answers

Product Description

Simparica is a safe, monthly chewable tick and flea preventative for dogs. Available by prescription, it works quickly and provides an entire month of protection. It goes to work killing ticks within 8 hours and fleas within 3 hours, maintaining its effectiveness until the next dose. 

Who is Simparica Chewable Tablets for Dogs for?

For dogs ages 6 months and up.

Why use Simparica Chewable Tablets for Dogs?

Features of Simparica:
  • Protects against ticks and fleas for a full month
  • Rapidly relieves existing flea infestations, even for dogs allergic to fleas
  • Improves clinical signs of flea allergies by killing fleas
  • Kills fleas before they lay eggs, controlling and preventing flea infestation in your home
  • Kills ticks quickly, helping to reduce the risk of life-threatening tick and flea-born diseases
  • Easy to administer
  • May be broken up and combined with food or administered directly

How does Simparica Chewable Tablets for Dogs work?

The active ingredient in Simparica is sarolaner, which inhibits the function of the glutamate receptor and neurotransmitter gamma aminobutyric acid (GABA) receptor and works in insects at the neuromuscular junction. This leads to acarine or insect death caused by uncontrolled neuromuscular activity.



Active ingredient(s):


How is Simparica Chewable Tablets for Dogs sold?

Simparica tablets are sold in a 3 monthly supply of 3 tablets or a 6 month supply of 6 tablets dependent on your dogs weight.

What are the side effects of Simparica Chewable Tablets for Dogs?

Most common side effects include diarrhea and vomiting.

Simparica may also cause abnormal neurologic signs, including:
  • Decreased conscious proprioception (body movement and position awareness)
  • Tremors
  • Absent or decreased menace (blinking reflex)
  • Ataxia (loss of full control of bodily movement)
  • Seizures

What special precautions are there?

Keep out of reach of animals and children.

Not approved for safe use in lactating, breeding, or pregnant dogs.

Not for human or cat consumption.

Should not be administered to dogs under 2.8 pounds or under 6 months old.

What to do if overdose?

Contact your closest emergency animal hospital or veterinarian.

How can I store Simparica Chewable Tablets for Dogs?

Store tablets at or below 86°F (30°C) with excursions permitted up to 104°F (40°C).

Helpful Tips:

For continuous protection, it is recommended to administer Simparica at the same time each month.

Simparica may be given with or without food.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.


Encourage your dog to chew, rather than swallow their dosage (1 tablet) of Simparica. If your dog commonly swallows treats whole, you can break the tablet into pieces. Ensure that your dog consumes the complete dose. If you suspect that a full dose wasn't consumed, redosing is recommended.

Main Ingredients

Simparica is manufactured by Zoetis and contains the active ingredient sarolaner.

Product Label Color / Dog’s Weight / Amount of Sarolaner per Tablet
Yellow                         2.8 - 5.5 lbs                         5 mg
Purple                          5.6 - 11 lbs                        10 mg
Orange                       11.1 - 22 lbs                        20 mg
Blue                            22.1 - 44 lbs                        40 mg
Green                         44.1 - 88 lbs                        80 mg
Brown                       88.1 - 132 lbs                      120 mg

To learn more about Simparica the fast-acting, long-lasting flea and tick protection for dogs, see our Product Spotlight on Simparica.

Check out our comparison guides below to see how Simparica compares to other flea treatments.

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Simparica Chewable Tablets for Dogs

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