Comfortis vs Seresto

As a pet parent, your primary concern is the health of your dog or cat. Choosing the best flea and/or tick treatment is an essential part of keeping your pet healthy, happy, and well-protected. Comfortis Chewable Tablets and Seresto are a couple of the best-loved treatments available. Both products are dependable and effective, but they are also incredibly different from one another. See below to learn how they compare!

Comfortis Chewables for Dogs

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Seresto for Dogs

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What makes Comfortis different from Seresto?

Perhaps the most glaring difference between these two products is that Comfortis is an oral flea treatment. Seresto is a collar that works to kill and repel fleas, kill flea larvae and eggs, kill and repel ticks, and treat chewing lice and sarcoptic mange. Comfortis uses Spinosad as its active ingredient, while Seresto features Imidacloprid and Flumethrin.

Comfortis is administered once monthly. A Seresto collar can last for as long as 8 months. Seresto is safe for use on breeding, lactating, or pregnant dogs, while Comfortis has not been evaluated for safety in these cases. Puppies as young as 7 weeks old can use Seresto, and puppies over 14 weeks old can take Comfortis. Comfortis is a prescription-only medication, and Seresto is available over-the-counter.

How do I make the decision between Comfortis and Seresto?

Your decision might simply depend on your own preferences. If the thought of a collar that lasts up to 8 months appeals to you, you might want to choose Seresto. If you would prefer a chewable tablet instead, Comfortis is a great choice. If your dog is pregnant, breeding, or lactating, Seresto is the safe option. If chewing lice and sarcoptic mange are a concern, Seresto is a great way to deal with those issues.

Talk to your veterinarian to decide on the best treatment option for your dog. Your vet will be happy to answer your questions and confirm whether or not they agree on the product you’ve chosen. If you think of any other questions and you could benefit from pet parent counseling, reach out to the skilled Allivet pharmacists!

Feature Comfortis Seresto
Kills Fleas Yes Yes
Repels Fleas No Yes
Kills Flea Eggs and Larvae No Yes
Kills Ticks No Yes
Repels Ticks No Yes
Repels Mosquitoes No No
Prevents Heartworm No No
Other Parasites No Chewing Lice and Sarcoptic Mange
Waterproof Yes since taken orally Yes
How Long to work Begins to kills fleas in 30 minutes Kills fleas in 24 hours and repels or kills re-infesting ticks within 6 hours
Taste Beef flavored N/A
Active Ingredient Spinosad Flumethrin and Imidacloprid
RX Required Yes No
Application Type Chewable Tablet Collar
Dosing 1 tablet per month 1 collar lasts up to 8 months
Age Dogs and cats 14 weeks and older Dogs 7 weeks and older
Manufacturer Elanco Animal Health Bayer Animal Health
Safety Not evaluated for safe use in breeding, pregnant, and lactating dogs. Breeding, pregnant, and lactating dogs may use.

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