Trifexis vs Comfortis

The health of your furry friend is paramount to a happy life for the both of you. Finding the right parasite treatment is one way to ensure that health and happiness. At Allivet, we believe in making your life as easy as possible. To that end, we've created a comparison chart between two popular brands, Trifexis Chewable Tablets and Comfortis Chewable Tablets. This information should help you narrow down your options and choose the best one for you and your pet.

Trifexis Chewables for Dogs

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Comfortis for Dogs

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What are the differences between Trifexis and Comfortis

At face value, these two treatments may look very similar. Each product is a chewable tablet with an appealing beef flavor. Each product is administered monthly, and they both kill fleas.

Surprisingly, there are actually more differences between these two effective medications. Trifexis is a combination of two medications that handle fleas and parasites. Comfortis deals only with fleas. Trifexis can be given to puppies as early as 8 weeks and 5 pounds, while Comfortis is safe for puppies a minimum of 14 weeks old.

Another similarity between these two top-quality products is that they both use an ingredient called Spinosad, which begins to kill fleas within 30 minutes. This is intended to prevent fleas from laying eggs and causing prolonged irritation to pup. Trifexis also contains Milbemycin Oxime, which is an agent designed to eliminate intestinal parasites such as roundworm, hookworm, and whipworm. It is also a heartworm preventative.

Unlike Comfortis, Trifexis chewable tablets are not available for cats. Neither of these products have been evaluated for use in breeding, pregnant, or lactating dogs.

Trifexis and Comfortis both require a prescription from your veterinarian. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog or cat.

Final Thoughts on Trifexis vs Comfortis

Overall, the costs for Trifexis and Comfortis are roughly the same. With the added benefit of deworming, some pet owners may prefer Trifexis. Alternatively, due to accessibility for your feline companion, some pet owners might choose Comfortis for its ease of use in a home with both cats and dogs. Certain pet parents (alongside their veterinarians) may opt to switch over to an alternative to protect breeding, pregnant, and lactating dogs.

If you still have questions on which oral flea and tick treatment is best for your furry friend, our pharmacists are standing by to offer pet parent consultations.

Feature Trifexis Comfortis
Kills Fleas Yes Yes
Repels Fleas No No
Kills Flea Eggs and Larvae Yes No
Kills Ticks No No
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes No
Other Parasites Roundworm, hookworm, and whipworm No
Waterproof Yes since taken orally Yes since taken orally
How Long to work Kills 100% of biting fleas in 4 hours Begins to kills fleas in 30 minutes
Taste Beef Flavored Beef flavored
Active Ingredient Spinosad and Milbemycin Oxime Spinosad
RX Required Yes Yes
Application Type Chewable Tablet Chewable Tablet
Dosing 1 tablet per month 1 tablet per month
Age Puppies 8 weeks and older and weigh more than 5 lbs. Dogs and cats 14 weeks and older
Manufacturer Elanco Animal Health Elanco Animal Health
Safety Not yet evaluated for use of in breeding, pregnant, or lactating dogs. Not evaluated for safe use in breeding, pregnant, and lactating dogs.

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