Frontline Plus vs Advantage II

A critical part of keeping your dog healthy and happy is controlling annoying and dangerous fleas and other parasites. Two of the best options for protecting your dog from pests are Frontline Plus and Advantage II. Each of these incredible flea and/or tick treatments works in a unique way to combat infestations, and they each provide their own set of advantages that can help with your decision. See below for a table and more information about these two effective options!

What are the key differences between Frontline Plus and Advantage II?

These two effective products are similar in a number of ways. Firstly, they are both topical flea treatments.They are both administered monthly, and each product is safe for use in puppies. Advantage II can be administered to puppies as young as 7 weeks, and Frontline Plus is safe from an age of 8 weeks. Neither product requires a prescription. They both begin killing fleas within 12 hours, and they both eliminate adult fleas, flea eggs and larvae and lice.

Now, let’s discuss the many differences between these two medications. Frontline Plus is safe for use in pregnant, lactating, or breeding dogs. Before using Advantage II in your pregnant, breeding, or lactating dog, you should always consult your veterinarian to determine safety.

Advantage II contains Pyriproxyfen and Imidacloprid, while Frontline Plus combines (S)-Methoprene with Fipronil. Frontline Plus also kills ticks.

Closing thoughts about Frontline Plus vs. Advantage II

While you can’t go wrong with either of these high-quality treatment options, there are some considerations that might help you make your decision. If your pet is pregnant, breeding, or lactating, you’ll want to choose Frontline Plus. If your dog could benefit from tick protection, Frontline Plus is the way to go. However, if your dog is prone to lice, Advantage II is an ideal choice.

If you need help with choosing the best product for your dog, reach out to the Allivet pharmacists for a pet parent consultation! Our pharmacists can answer your questions and address your concerns. The Allivet pharmacists are up to date on every product offered by Allivet, so they are an excellent (and free!) resource for pet parents.

Frontline Plus for Dogs

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Advantage II for Dogs

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Feature Frontline Plus Advantage II
Kills Fleas Yes Yes
Repels Fleas No No
Kills Flea Eggs and Larvae Yes Yes
Kills Ticks Yes No
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm No No
Other Parasites Treats lice Treats lice
Waterproof Yes Yes
How Long to work 12 hours to kill fleas and 48 hours to kill ticks Begins to kill fleas within 12 hours
Taste N/A N/A
Active Ingredient Fipronil and (S)-Methoprene Imidacloprid and Pyriproxyfen
RX Required No No
Application Type Topical Topical
Dosing 1 topical application per month 1 application per month
Age Dogs 8 weeks and older Dogs 7 weeks and older
Manufacturer Boehringer Ingelheim Bayer Animal Health
Safety Breeding, pregnant, and lactating dogs may use. Speak to your vet about risks associated with breeding, pregnant, or lactating dogs

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