Simparica Trio vs Revolution

Pet parents can all agree that keeping your dog healthy and happy is a top priority. Because of this, choosing the best parasite and heartworm preventative is a big part of your role as a dog parent. Two of the best-loved treatments are Simparica Trio and Revolution, It can be difficult to weigh the options, but we’ve put together the following table and information to help you make the best decision for your pup.

Simparica Trio

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Save $5 off $50
with coupon code COMPARE5

How is Simparica Trio different from Revolution?

While these two medications are different in many ways, they also share some common traits. One important parallel is that they both protect dogs against heartworms. They also both work to kill fleas and ticks (with Revolution acting only against American dog ticks). Both of these monthly prescription-only treatments are safe for use in puppies. Simparica Trio can be used in puppies over 2.8 pounds and 8 weeks of age, while Revolution is safe for puppies as young as 6 weeks of age.

These two effective products have many unique characteristics that set them apart from one another. Simparica Trio combines three active ingredients - Pyrantel, Saroloner, and Moxidectin. In addition to protecting against the parasites listed above, this formula defends dogs against roundworms and hookworms. It also works to kill flea larvae and eggs. The tasty, chewable tablets offer an appealing beef flavor. This product has not been evaluated for safe use in lactating, breeding, or pregnant dogs.

Revolution takes a different approach to parasite protection. It contains a single active ingredient called Selamectin. This ingredient offers added protection against sarcoptic mange and ear mites. It also works to inhibit the development of flea larvae and eggs, and it works quickly to start killing fleas. It begins eliminating fleas within just 12 hours of application. This topical formula is also safe for use in breeding or pregnant dogs.

While the two products discussed here are formulated only for use in dogs, Revolution for Cats is the feline-friendly version of Revolution for Dogs.

Takeaways on Simparica Trio vs. Revolution

If you’re searching for a great way to protect your dog against heartworms, fleas, and ticks, you can’t go wrong with either of these amazing products. Answering the following questions can help you weigh these two incredible options.

  1. Do you have a puppy between 6 and 8 weeks old? If so, Revolution is the safest choice for your young pup.
  2. Is your dog pregnant or breeding? If your answer is yes, you’ll want to use Revolution because it has been proven safe for use under those conditions.
  3. Are you on the hunt for the most broad-spectrum parasite preventative? If so, Simparica Trio might be the way to go. It protects against more parasites, including hookworms, roundworms, and fleas in the larval and eggs stages.
  4. Is your dog prone to ear mites or sarcoptic mange? If this is the case, Revolution could be a great treatment for your canine companion.

Talk to your veterinarian to determine whether or not one of these products is the right choice for your dog. Be sure to address any concerns you have during your dog’s vet appointment. If you think of any other questions after you get back home, don’t worry - the Allivet pharmacists are available for pet parent consultations! They have the most up-to-date information on these medications, along with every other Allivet product.

Feature Simparica Trio Revolution
Kills Fleas Yes Yes
Repels Fleas No No
Kills Flea Eggs and Larvae Yes Stops development
Kills Ticks Yes American Dog Ticks
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes Yes
Other Parasites Hookworms and roundworms Ear Mites and Sarcoptic Mange
Waterproof Yes since taken orally Yes, after 2 hours
How Long to work N/A Begins to kill fleas within 12 hours
Taste Beef flavored N/A
Active Ingredient Sarolaner, moxidectin, and pyrantel Selamectin
RX Required Yes Yes
Application Type Chewable Tablet Topical
Dosing 1 tablet per month Applied monthly
Age Dogs 8 weeks and 2.8lbs or more Dogs 6 weeks and older
Manufacturer Boehringer Ingelheim Zoetis
Safety has not been evaluated in breeding, pregnant, or lactating dogs. Breeding, pregnant, and lactating dogs may use.