Simparica Trio vs Sentinel

Parasites are more than bothersome - they’re also potentially detrimental to your dog’s health and happiness. Pet parents can easily become overwhelmed when they begin researching the many parasite and heartworm preventative options. Two of the most popular treatments are Simparica Trio and Sentinel. These products are similar in some ways, but quite different in others. Read on to see a table and more information on these two effective, top-quality products.

Simparica Trio

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How do Simparica Trio and Sentinel differ?

First, let’s highlight the similarities between these two effective medications. Both formulas protect dogs against heartworms, roundworms, and hookworms. They both come in the form of a chewable, beef-flavored tablet. Each product requires a prescription, and they are both administered monthly. Both of these medications are safe for use in puppies as well. Simparica Trio can be safely administered to puppies over 8 weeks old weighing at least 2.8 pounds, while Sentinel can be given to puppies as young as 4 weeks old.

While either formula would be a great way to defend your dog against fleas, they each take a unique approach to flea protection. Simparica Trio uses a trio of ingredients to protect your dog against the aforementioned parasites, but it also kills ticks, flea eggs, flea larvae, and adult fleas. Combining Moxidectin, Saroloner, and Pyrantel, this potent formula is effective and comprehensive. It has not been evaluated for safe use in pregnant, breeding, or lactating dogs.

Sentinel contains two active ingredients - Lufenuron and Milbemycin Oxime. Together, these ingredients offer added protection against whipworms. They also work to break the life cycle of fleas by inhibiting the development of their eggs and larvae. It is also safe for use in pregnant, breeding, or lactating dogs.

How can I choose between Simparica Trio and Sentinel?

Deciding between these products can be as simple as considering your puppy’s age or weight. If your puppy is over 2.8 pounds and 8 weeks old, you can safely choose either formula. However, if your puppy is under 2.8 pounds or between the ages of 4 and 8 weeks, Sentinel is the safest choice.

You might make your decision based on the parasite protection you hold most important. If fleas and ticks are concerning for you and your pup, Simparica Trio is a great way to defend your dog against these pests while you protect him or her against internal worms. If your dog is prone to whipworms and you also want to protect your pup against fleas, Sentinel is an excellent way to do so. Finally, if you have a pregnant, lactating, or breeding dog, you’ll want to opt for the safest choice - Sentinel.

Consult your veterinarian to finalize your decision and get a prescription for your dog. Be sure to bring all of your dog’s prescriptions to Allivet, where you’ll find the lowest prices on meds, supplements, food, treats, and everything else you need to keep your pup healthy and happy! If you have any concerns or questions about these or any other Allivet products, our pharmacists are standing by for pet parent consultations.

Feature Simparica Trio Sentinel
Kills Fleas Yes No
Repels Fleas No No
Kills Flea Eggs and Larvae Yes Stops development
Kills Ticks Yes No
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes Yes
Other Parasites Hookworms and roundworms Roundworms, Whipworms, and Hookworms
Waterproof Yes Yes
How Long to work N/A Breaks cycle of fleas and eggs. Does not kill existing flea infestation.
Taste Beef flavored Savory Beef
Active Ingredient Sarolaner, moxidectin, and pyrantel Milbemycin Oxime and Lufenuron
RX Required Yes Yes
Application Type Chewable Tablet Chewable Tablet
Dosing 1 tablet per month 1 tablet per month
Age Dogs 8 weeks and 2.8lbs or more Dogs 4 weeks and older
Manufacturer Boehringer Ingelheim Merck Animal Health
Safety has not been evaluated in breeding, pregnant, or lactating dogs. Breeding, pregnant, and lactating dogs may use.