Trifexis vs Frontline Plus

Keeping your furry friend safe from parasite infestations is paramount for a happy and healthy pup. Two of the most popular treatment options, Trifexis Chewable Tablets and Frontline Plus, each offer different advantages. The table and additional information below will help you make an informed decision about which product is best for your pet.

Trifexis Chewables for Dogs

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Frontline Plus for Dogs

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What are the differences between Trifexis and Frontline Plus

Trifexis is a beef-flavored oral medication. Frontline Plus is applied topically. Both medications are conveniently administered once a month. Both Trifexis and Frontline Plus can be given to pets as early as 8 weeks, with the main difference being that your dog must weigh 5 pounds to use Trifexis..

Trifexis uses Spinosad and Milbemycin Oxime, and it begins to kill fleas in as little as 30 minutes. It eliminates all fleas within 4 hours. Trifexis eliminates internal parasites such as roundworm, hookworm, and whipworm. It also prevents heartworm. Frontline Plus uses Fipronil, an insect growth regulator, and (S)-Methoprene. This is effective in disrupting the central nervous system of the insects, which results in parasite death. It has the added benefit of eliminating lice.

Both products are safe for dogs when used as directed. However, unlike Frontline Plus, Trifexis has not yet been evaluated for use in breeding, pregnant, or lactating dogs. Frontline Plus is also available for your feline companions.

Trifexis requires a prescription from your veterinarian. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog.

Final Thoughts on Trifexis vs. Frontline Plus

If you prefer a topical treatment option, Frontline Plus is a great choice. If your preference is oral administration, Trifexis might be the way to go. If your dog is pregnant, breeding, or lactating, Frontline Plus is a safe option.

If your pet is dealing with a lice problem, Frontline Plus is a great way to combat that issue and deal with fleas simultaneously. If you’d rather provide your dog with protection against heartworms, roundworms, whipworms, and hookworms as you treat fleas, choose Trifexis.

Speak with your veterinarian to make an official decision on the best treatment for your dog. Your vet can address all your concerns and questions. You can also reach out to the incredible Allivet pharmacists for a pet parent consultation if you find yourself with any further questions!

Feature Trifexis Frontline Plus
Kills Fleas Yes Yes
Repels Fleas No No
Kills Flea Eggs and Larvae Yes Yes
Kills Ticks No Yes
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes No
Other Parasites Roundworm, hookworm, and whipworm Treats lice
Waterproof Yes since taken orally Yes
How Long to work Kills 100% of biting fleas in 4 hours 12 hours to kill fleas and 48 hours to kill ticks
Taste Beef Flavored N/A
Active Ingredient Spinosad and Milbemycin Oxime Fipronil and (S)-Methoprene
RX Required Yes No
Application Type Chewable Tablet Topical
Dosing 1 tablet per month 1 topical application per month
Age Puppies 8 weeks and older and weigh more than 5 lbs. Dogs 8 weeks and older
Manufacturer Elanco Animal Health Boehringer Ingelheim
Safety Not yet evaluated for use of in breeding, pregnant, or lactating dogs. Breeding, pregnant, and lactating dogs may use.

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