Trifexis vs K9 Advantix II

Nothing matters more to a pet parent than keeping their pet happy, healthy, and protected. Therefore, you’ll likely find yourself comparing medications to accomplish that goal. For parasite protection, two of the most popular options are Trifexis Chewable Tablets and K9 Advantix II.With this comparison chart and the additional information below, you'll be able to make an easy and informed decision about what works best for your pet.

Trifexis Chewables for Dogs

Buy Trifexis Today

K9 Advantix for Dogs

Buy K9 Advantix II Today

What are the differences between Trifexis and K9 Advantix II

The most obvious difference between these products is that Trifexis is a chewable tablet, while K9 Advantix II is a topical solution. Both medications are given to your pet once a month. The added benefit of K9 Advantix II is that due to its topical nature, it kills and/or repels fleas, ticks, biting flies, and even mosquitoes. It also treats lice. K9 Advantix II doesn't require a prescription and can be given as early as 7 weeks, as long as the puppy weighs at least 4 pounds. Trifexis requires a prescription, and it is safe for puppies at least 8 weeks old weighing a minimum of 5 pounds.

K9 Advantix II combines Permethrin, Imidacloprid, and Pyriproxyfen, and it begins to kill fleas in 12 hours. Trifexis uses Spinosad and Milbemycin Oxime, and it starts to kill fleas in as little as 30 minutes. It eliminates all fleas within 4 hours.

Both products are safe for dogs, as long as they are used as directed. K9 Advantix II is considered safe for use in pregnant or lactating dogs, while Trifexis is not yet evaluated for use in these circumstances. Check with your veterinarian to determine what is right for your pet.

Neither product is formulated for use in cats. As mentioned, Trifexis requires a prescription, while K9 Advantix II does not. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog.

Final Thoughts on Trifexis vs K9 Advantix II

Overall, the accessibility of K9 Advantix II offers relief to pets if you are unable to quickly obtain a prescription. There is a difference in cost between these two products. Trifexis is a prescription, and it is slightly more costly than K9 Advantix II. Some pet owners and their vets may start with K9 Advantix II, then switch to Trifexis later. Additionally, some pet owners may opt to stop using Trifexis and choose K9 Advtantix to protect breeding, pregnant, and lactating dogs.

If you still have questions on which oral flea and tick treatment is best for your furry friend, our pharmacists are standing by to offer pet parent consulting.

Feature Trifexis K9 Advantix
Kills Fleas Yes Yes
Repels Fleas No Yes
Kills Flea Eggs and Larvae Yes Yes
Kills Ticks No Yes
Repels Ticks No Yes
Repels Mosquitoes No Yes
Prevents Heartworm Yes No
Other Parasites Roundworm, hookworm, and whipworm Lice & Biting Flies
Waterproof Yes since taken orally Yes
How Long to work Kills 100% of biting fleas in 4 hours 12 hours to kill fleas
Taste Beef Flavored N/A
Active Ingredient Spinosad and Milbemycin Oxime Permethrin, Imidacloprid, and Pyriproxyfen
RX Required Yes No
Application Type Chewable Tablet Topical
Dosing 1 tablet per month Monthly application
Age Puppies 8 weeks and older and weigh more than 5 lbs. Puppies 7 weeks and older and weighing more than 4 lbs.
Manufacturer Elanco Animal Health Bayer Animal Health
Safety Not yet evaluated for use of in breeding, pregnant, or lactating dogs. Don't apply to cats

Other Trifexis Comparisons

Other K9 Advantix II Comparisons